Antioxidant and hepatoprotective potentials of novel endophytic fungus  Achaetomium  sp., from  Euphorbia hirta

Anitha, K.P.G. Uma; Sathiavelu, Mythili

doi:10.1016/j.apjtm.2017.06.008

Cited by 28 publications

(13 citation statements)

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“…Ethyl acetate extract of another endophytic fungus, Achaetomium sp. isolated from E. hirta , was estimated to have 218.16 mg RE/g TFC (Anitha and Mythili 2017 ). Ethyl acetate solvent is the most efficient, and selectively extracts the high molecular weight polyphenols and low molecular weight phenolic components (Garcia et al 2012 ; Scholz and Rimpler 1989 ).…”

Section: Discussionmentioning

confidence: 99%

Phenolic and flavonoid contents and antioxidant activity of an endophytic fungus Nigrospora sphaerica (EHL2), inhabiting the medicinal plant Euphorbia hirta (dudhi) L.

et al. 2022

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Graphical abstract Since endophytic fungi are pivotal sources of various bioactive natural compounds, the present study is aimed to investigate the antioxidant compounds of the endophytic fungus Nigrospora sphaerica isolated from a pantropical weed, Euphorbia hirta L. The fungus was fermented in four different media and each filtered broth was sequentially extracted in various solvents. Crude extracts collected from different solvents were subjected to phytochemical analysis and antioxidant activity. The total phenolic content (TPC) and total flavonoid content (TFC) were maximal in ethyl acetate crude extract (EtOAcE) of endophyte fermented in potato dextrose broth (PDB) medium (77.74 ± 0.046mgGAE/g and 230.59 ± 2.0 mgRE/g) with the highest 96.80% antioxidant activity. However, TPC and TFC were absent in hexane extract of Czapek Dox broth (CDB) medium exhibiting the lowest 4.63 ± 2.75% activity. The EtOAcE (PDB) showed a positive correlation between TFC and antiradical activity ( R 2 = 0.762; P < 0.05), whereas a high positive correlation was noticed between TPC and antioxidant activity ( R 2 = 0.989; P < 0.05). Furthermore, to determine the antioxidant activity, EtOAcE (PDB) was subjected to TLC bioautography-based partial purification, while GC/MS analysis of the partial purified extract was done to confirm the presence of phenolics along with antioxidant compounds that resulted in the detection of 2,4-Di-tert-butylphenol (13.83%), a phenolic compound accountable for the antioxidant potential. Conclusively, N. sphaerica is a potential candidate for natural antioxidant. Supplementary Information The online version contains supplementary material available at 10.1007/s00203-021-02650-7.

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Section: Discussionmentioning

confidence: 99%

Phenolic and flavonoid contents and antioxidant activity of an endophytic fungus Nigrospora sphaerica (EHL2), inhabiting the medicinal plant Euphorbia hirta (dudhi) L.

et al. 2022

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“…The ethyl acetate extract of Achaetomium sp. hosted by Euphorbia hirta has been reported to protect against CCl 4 induced toxicity in HepG2 cells as evidenced by 72.13% of cell viability at a concentration of 150 mg/mL compared to 93.26% cell viability reported for the standard, silymarin [78].…”

Section: Hepatoprotective Activitymentioning

confidence: 95%

Therapeutic potentials of endophytes for healthcare sustainability

Falade

Adewole

Ekundayo

2021

Egyptian Journal of Basic and Applied Sciences

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Morbidity and mortality rates are on the upward trajectory globally, probably due to lack of effective treatments and poor healthcare. Most effective drugs are, however, characterized by serious side effects upon long usage. It is, therefore, imperative to explore natural sources for efficient therapeutics with little or no side effects. This paper outlines the therapeutic potentials of endophytes using published articles on endophytes in both Web of Science (WoS) and Scopus (1990Scopus ( -2020. Scientific evidences discussed in this review suggest endophytic microbes as reservoirs of novel bioactive compounds belonging to the following classes alkaloid, xanthones, methoxyphenols, depsipeptide, bicyclic lactones, depsidoenes, butenolides, maleimide-bearing compounds, ergosterol, spirobisnaphthalenes, benzopyran derivatives, isofuranonaphthalenone, butyrolactones, diketopiperazine, sesquiterpenoids, cytochalasin-related compounds, pestalols and cyclic pentapeptides. The identified compounds are characterized by promising therapeutic potentials such as antioxidant, anti-inflammatory, antimicrobial, anticancer, antidiabetic, antiviral, neuroprotective, and hepatoprotective properties, which are significant to healthy living and sustainable healthcare. This review further discusses the emerging potentials of endophytes in the production of antibiofilm, antimultiresistant Staphylococcus aureus (anti-MRSA) and lipase inhibitors (LIs). The prospective applications of endophytes in the development of anti-COVID-19 medications and therapeutics for the management of neglected tropical diseases (NTDs) are also advocated in this review. The therapeutic potentials of endophytes, if properly harnessed, would in no small measure contribute to good health, which is an integral part of the sustainable development goals (SDGs) of the United Nations (UN).

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“… Actinomycetes strain EHL27 Achaetomium sp. Phenols, Flavonoids, and Tannins Hepatoprotective, antimicrobial, and antioxidant activities Jain et al [ 143 ]; Jain et al [ 136 ]; Upadhyay et al [ 204 ]; Meena and Yadav [ 161 ]; Syed et al [ 162 ]; Anitha and Mythili [ 163 ] Aloe vera (L.) Burm.f. Leaves gel Leaf cut laterally, and Curcuma aromatica poweder is sprinkled on the cut portion, warm and tied locally on both sides of fracture bone.…”

Section: Endomicrobial Diversity Of Important Medicinal Plants/genusmentioning

confidence: 99%

“…An experimental study on ethyl acetate extract of endophytic fungus Achaetomium sp., recorded from E. hirta suggests that it demonstrates antioxidant potential due to the presence of phenolic, flavonoid, and tannin content. It was examined by using DPPH radical scavenging assay and well diffusion assay and revealed the amount of present phenolic content (44.02 ± 1.57 mg), flavonoid content (54.54 ± 1.82 mg), and tannin content (18.790 ± 1.018 mg) [ 163 ].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals

Yadav

Meena

2021

Biotechnology Reports

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Highlights Endophytes act as chemical synthesizers of the secondary metabolites of the host plant. Endophytic microflora has been isolated from a wide array of plants. It can serve as a good alternative source for pharmaceutically important compounds. The arid ecosystem of Thar Desert is a rich repository of ethnomedicinal plants. Role of endophytes in the synthesis of bioactive molecules used to enhance production.

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Antioxidant and hepatoprotective potentials of novel endophytic fungus Achaetomium sp., from Euphorbia hirta

Abstract: The results reveal that the metabolites produced by endophytic fungi isolated from Euphorbia hirta could be novel natural products that could lead to new drug discovery.

Cited by 28 publications

References 28 publications

Phenolic and flavonoid contents and antioxidant activity of an endophytic fungus Nigrospora sphaerica (EHL2), inhabiting the medicinal plant Euphorbia hirta (dudhi) L.

Phenolic and flavonoid contents and antioxidant activity of an endophytic fungus Nigrospora sphaerica (EHL2), inhabiting the medicinal plant Euphorbia hirta (dudhi) L.

Therapeutic potentials of endophytes for healthcare sustainability

Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals

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