Antioxidant and Hepatoprotective Potentiality of Randia dumetorum Lam. Leaf and Bark via Inhibition of Oxidative Stress and Inflammatory Cytokines

Kandimalla, Raghuram; Kalita, Sanjeeb; Saikia, Bikas; Choudhury, Bhaswati; Singh, Yogendra; Kalita, Kasturi; Dash, Suvakanta; Kotoky, Jibon

doi:10.3389/fphar.2016.00205

Cited by 33 publications

(32 citation statements)

References 36 publications

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“…The liver has many functions, such as nutrient metabolism (Kandimalla et al, 2016). However, the liver is susceptible to damage from toxic substances, including alcohol and drug abuse, viral infections, incidental poisoning, and so on (Domitrović et al, 2013;Peng et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Selenium‐Enriched Red Radish Sprouts on Carbon Tetrachloride‐Induced Liver Injury in Mice

Wang

Sun

et al. 2019

Journal of Food Science

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This study aimed to investigate the effect of Se (Selenium) treatment on nutritional quality in radish sprouts. The results showed that 15 µM sodium selenite significantly increased phenolics compounds, flavonoids compounds, anthocyanins, and some essential amino acid content, while improving the total antioxidant capacity of radish sprouts. Besides, the Se‐enriched radish sprouts significantly alleviated the liver damage caused by carbon tetrachloride (CCl4) in mice and improved the antioxidant capacity of the liver in mice, whereas the Se‐enriched radish sprouts alleviated the inflammatory reaction and apoptosis caused by CCl4. These results imply that Se‐enriched radish sprouts have a positive impact on mice with CCl4‐induced liver injury, and that in future Se‐enriched radish sprouts could be developed into an effective food and health care product for the liver injury prevention. Practical Application Because selenium is an essential trace element in the human body, selenium‐enriched sprouts can help eliminate free radicals in the body, relieve aging, and selenium‐deficient diseases. They are easy to grow and have low costs. Hence, selenium‐enriched sprouts have a great potential of being widely consumed.

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Section: Introductionmentioning

confidence: 99%

Protective Effect of Selenium‐Enriched Red Radish Sprouts on Carbon Tetrachloride‐Induced Liver Injury in Mice

Wang

Sun

et al. 2019

Journal of Food Science

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“…Oxidative reaction is induced and exaggerated by an imbalance the activities of ROS and antioxidant molecules and excessive ROS production causes various diseases (Kandimalla et al, 2016;Sarwar et al, 2015). To investigate the anti-oxidative activity of SKL, we measured SOD-like activity.…”

Section: Effect Of Skl On Sod-like Activity and Dpph Radical Scavengimentioning

confidence: 99%

Anti-oxidant and anti-inflammatory effects of Salix Koreensis Andersson in DC. leaf methanol extract in vitro models

Kim¹,

Kim²

2016

TANG [HUMANITAS MEDICINE]

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Oxidative rancidity in foods causes undesirable changes in nutritive value, aroma, flavor, and color. Salix Koreensis Andersson in DC. (SK) has anti-oxidative and anti-inflammatory effects and is traditionally used to treat neuralgia, edema, pain, and inflammatory diseases. However, the regulatory effects of SK on oxidative and inflammatory reactions have not been elucidated. In this context, we scientifically validated the anti-oxidative and anti-inflammatory activities of SK leaf (SKL). The methanol extract of SKL was evaluated for in vitro anti-oxidative activities. SKL showed increased superoxide dismutase (SOD)-like activity and 1, 1-diphenyl-2-picrylhydrazyl radical scavenging activity. The in vitro anti-oxidant and antiinflammatory activities of SKL were also investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. LPS resulted in decreased SOD activities compared with the unstimulated cells, but SKL significantly increased SOD activities reduced by LPS. In addition, LPS-induced nitric oxide, tumor necrosis factor-α, and interleukin-6 productions were significantly and dose-dependently reduced by SKL in RAW264.7 macrophages without inducing cytotoxicity. In conclusion, these results indicate that SKL will be able to be effectively used as a food additive with anti-oxidative and anti-inflammatory effects.

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“…Reduced glutathione (GSH) levels were measured by following Kandimalla et al (2016c). Lipid peroxidation was determined by measuring the thiobarbituric acid reactive substances (TBARS) (Ohkawa et al, 1979).…”

Section: Methodsmentioning

confidence: 99%

Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade

Kandimalla

Dash²,

Kalita

et al. 2017

Front. Cell. Neurosci.

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The present study explains the neuroprotective ability of bioactive fractions of Annona reticulata bark (ARB) and Ziziphus jujuba root bark (ZJ) along with insulin against diabetic neuropathy. By using different solvents of increasing polarity ARB and ZJ were undergone for bioactive guided fractionation. The neuroprotective ability of the all the plant fractions were tested against H2O2 induced toxicity in SHSY5Y neuroblastoma cell lines and DRG neuronal cells. Among all the fractions tested, the methanol extract of ARB and ZJ (ARBME and ZJME) and its water fractions (ARBWF and ZJWF) exhibited significant neuroprotection against H2O2 induced toxicity in SHSY5Y cells and DRG neuronal cells. Further both the active fractions were tested against streptozotocin (55 mg/kg i.p.) induced diabetic neuropathy in male Wistar rats. Body weight changes, blood glucose levels and pain threshold through hot plate, tail immersion, cold plate and Randall-Sillitto methods were measured throughout the study at weekly interval. After completion of the drug treatment period, all the animals were sacrificed to measure the sciatic nerve lipid peroxidation, antioxidative enzyme levels (SOD, catalase, and GSH) and cytokine levels (IL-1β, IL-6, IL-10, TNF-α, iNOS, and NFκB) through ELISA and western blotting analysis. Results of this study explain that ARBME, ZJME, ARBWF, and ZJWF along with insulin potentially attenuate the thermal, mechanical hyperalgesia and cold allodynia in diabetic neuropathic rats, where insulin treatment alone failed to diminish the same. Reduction of sciatic nerve oxidative stress, NF-κB and iNOS mediated inflammatory cascade and normalization of abnormal cytokine release confirms the possible mechanism of action. The present study confirms the neuroprotective ability of ARB and ZJ against painful diabetic neuropathy through inhibiting oxidative stress and NF-κB inflammatory cascade.

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Antioxidant and Hepatoprotective Potentiality of Randia dumetorum Lam. Leaf and Bark via Inhibition of Oxidative Stress and Inflammatory Cytokines

Cited by 33 publications

References 36 publications

Protective Effect of Selenium‐Enriched Red Radish Sprouts on Carbon Tetrachloride‐Induced Liver Injury in Mice

Protective Effect of Selenium‐Enriched Red Radish Sprouts on Carbon Tetrachloride‐Induced Liver Injury in Mice

Anti-oxidant and anti-inflammatory effects of Salix Koreensis Andersson in DC. leaf methanol extract in vitro models

Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade

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