Antioxidant and Hepatoprotective Effects of Rosa damascena

Achuthan, C R; Babu, B. Hari; Padikkala, José

doi:10.1076/phbi.41.5.357.15945

Cited by 100 publications

(59 citation statements)

References 9 publications

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“…Several Indian medicinal plants have been extensively used in the Indian traditional system of medicine for the management of liver disorder. Some of these plants have already been reported to posses strong antioxidant activity [9][10][11] . Chamomile recutita (CV Prashant) L. Rousch, (family Asteraceae), popularly known as Chamomile is a reputed medicinal and aromatic plant used in both traditional and modern system of medicine.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats

Gupta¹,

Misra²

2006

American J. of Pharmacology and Toxicology

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Hepatoprotective activity of aqueous ethanolic extract of Chamomile recutita capitula against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of aqueous ethanolic extract of Chamomile recutita capitula on blood and liver glutathione, Na + K + -ATPase activity, serum marker enzymes, serum bilirubin, glycogen and thiobarbutiric acid reactive substances against paracetamol induced damage in rats have been studied to find out the possible mechanism of hepatoprotection. It was observed that extract of chamomile has reversal effects on the levels of above-mentioned parameters in paracetamol hepatotoxicity. The extract of capitula of chamomile functions as a hepatoprotective agent and this hepatoprotective activity of chamomile may be due normalization of impaired membrane function activity.

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Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats

Gupta¹,

Misra²

2006

American J. of Pharmacology and Toxicology

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“…Phenolics are also famous for their antioxidant and radical scavenging activities. 6,25,26 Therefore the presence of diverse secondary metabolites and phenolics in ZES seems to be a suitable candidate as a hepatoprotective agent for human which is in accordance with the traditional uses. 11 As stated in British Pharmacopoeia for oral administration, the microbial contamination of these pathogens like E. coli and Salmonella must be negative which was true for ZES and each of its ingredients.…”

Section: Discussionmentioning

confidence: 99%

Physicochemical Characterization, Standardization and In vitro Determination of Radical Scavenging Activity of Zereshk-e- Saghir, A Traditional Preparation, and Its Ingredients

Sarhadynejad¹,

Pardakhty²,

Mandegary³

et al. 2017

JYP

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Objective: Quality control and standardization of traditional preparations ensure their safe, pure and efficient prescription. Zereshk-e-Saghir (ZES), a folk remedy, has been recommended as a hepatoprotective agent in Traditional Persian Medicine (TPM). This study aimed at the evaluation of the physicochemical and phytochemical characterization, standardization, and in vitro antioxidant capacity determination of ZES and its ingredients. Method: Some qualitative and quantitative controls were performed like ash value, moisture content, extractable matter, phytochemical screening, TLC fingerprint and microbial contamination. Total phenolic and emodin contents of ZES were measured by spectrophotometric method to standardize this preparation. Finally in vitro radical scavenging activity of ZES and its ingredients were determined using 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) assay. Result: Regarding the physicochemical evaluation, the amount of each parameter (ash value, moisture content, and extractable value) was determined as documented characteristics for ZES components. Phytochemical screening of ZES ingredients indicated the presence of tannins in all the samples and the presence of alkaloids, steroids and terpenoids in a majority of the samples. Meanwhile, ZES exhibited no pathogenic contamination. The emodin and total phenolic contents (TPC) of ZES were reported 457.0 µg emodin/100g and 381.5 mg gallic acid equivalents (GAE)/100 g of ZES, respectively. Also TPC ranged from 3607.4 to 27.9 mg GAE/ 100 g of ZES ingredients. Meanwhile, the results demonstrated that ZES could scavenge DPPH radicals (IC 50 value: 266.4 µg/ ml). Conclusion: The obtained results on quality control and standardization of ZES could be proposed as a monograph having standard characteristics.

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“…In addition to its perfuming effects, it was reported that the rose oil, rose flower extracts possessed a wide range of health beneficial activities, such as antibacterial 12,46,47 , antioxidant 13,14,48 , anti-infective and antiinflammatory properties 12,49 , anti-convulsant 50 and anti-HIV 11 . The extract of R. damascena induces the neurite outgrowth and inhibits the A β (25-35)-induce atrophy 51 .…”

Section: Rose Product and Its Usesmentioning

confidence: 99%

“…This plant was originally brought to Europe from Damascus that is why it is called Damask rose 9,10 . Besides its application in aromatic industries, some valuable characteristics of Damask rose oil such as anti-HIV 11 antibacterial 12 and antioxidant 13,14 activities have been reported recently. The worldwide demand for high quality rose oil is expected to increase in future.…”

Section: Introductionmentioning

confidence: 99%

Evaluation, Genetic Diversity, Recent Development of Distillation Method, Challenges and Opportunities ofRosa damascena: A Review

Pal

2013

Journal of Essential Oil Bearing Plants

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Rosa damascenaMill that is one of the important species of Rosa is used for essential oil production. It is a tetraploid rose that belongs to Damask group of roses. It is generally thought that the R. damascena originated in the Neo-lithic period, in South Anatolia, as a hybridization of R. gallica and R. phoenicea. Nevertheless, the origin of R. damascena is a bone of contention throughout the world. So far, 400 volatile substances have been identified in rose oil. Besides its application in aromatic and food industries, some valuable characteristics of Damask rose oil such as anti -HIV, antibacterial and antioxidant activities have been established during last two decades. The demand of rose oil in international market is increasing, but the area of production is stagnant. Thus, there is a pressing need to extend the cultivation of R. damascena to larger area and to improve its production technology. Rosa damascena possesses vast diversity in plant habit and flower characteristics. Over all, the research publication on this crop is scarce compared to other crops. Hence, this review will provide the valuable information for further research and understanding of the crop and its value as an economical crop.

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Antioxidant and Hepatoprotective Effects of Rosa damascena

Cited by 100 publications

References 9 publications

Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats

Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats

Physicochemical Characterization, Standardization and In vitro Determination of Radical Scavenging Activity of Zereshk-e- Saghir, A Traditional Preparation, and Its Ingredients

Evaluation, Genetic Diversity, Recent Development of Distillation Method, Challenges and Opportunities ofRosa damascena: A Review

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