Antioxidant and hepatoprotective activity of an ethanol extract of Syzygium jambos (L.) leaves

Abstract

Herbal medicines have traditionally been used worldwide for the prevention and treatment of liver disease with fewer adverse effects. The leaves of the Syzygium jambos (SJL) plant were chosen and studied for their antioxidant activity in vitro and hepatoprotective activity in vivo. The antioxidant activity of the ethanol extract was examined in vitro using a 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay, reducing capacity, total phenol, total flavonoid content, and total antioxidant capacity. The extract had significant dose-dependent antioxidant activity in all in vitro experiments. IC 50 values of SJL and ascorbic acid (standard) were found to be 14.10 and 4.87 μg/mL, respectively, according to a DPPH radical scavenging assay. Hepatoprotective activity of the plant extract was evaluated in a rat model of carbon tetrachloride (CCl 4 )-induced liver damage. CCl 4 significantly altered serum marker enzymes, total bilirubin, total protein, and liver weight. The extract caused these values to return to normal in rats with CCl 4 -induced liver damage that were given SJL. This indicated the hepatoprotective potential of SJL and was comparable to use of the standard drug silymarin. Thus, the present study revealed that SJL may have antioxidant and hepatoprotective activity.

Investigation of the antioxidant activity of chitooligosaccharides on mice with high-fat diet

“…The antioxidant activity of compounds was evaluated by measuring its scavenging capacity for the DPPH free radical (Islam et al, 2012). Therefore, DPPH assay, superoxide anion radical scavenging assay, and hydroxyl free radical scavenging assay were used as relevant indicator of antioxidant activity.…”

Extraction, Isolation, and Characterization of Bioactive Compounds and Essential Oil From Syzygium Jambos

“…Syzygium jambos is an evergreen tree of the family Myrtaceae, it was reported that several phenolic compounds and triterpenes have been isolated from the leaves of the S. jambos [8][9][10]. Moreover, S. jambos showed antioxidant, antiviral [11], anti-inflammatory [12], and antimicrobial activity [13].…”

Total protein, DNA and RNA content in the abdominal muscles of mice treated with Immunex DS and Hepatitis B Vaccine

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