Antioxidant and Hepatoprotective Activity of Lagenaria siceraria Aerial parts

Saha, Prerona; Mazumder, Upal Kanti; Haldar, Pallab Kanti; Gupta, Malaya; Sen, Suchandra; Islam, Aminul

doi:10.5530/pj.2011.23.10

Cited by 16 publications

(15 citation statements)

References 33 publications

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“…It cures pain, ulcers and fever and used for pectoral cough, asthma and other bronchial disorders especially syrup prepared from the tender fruits. 7 Some of the reported activities are Hypolipidemic and antihyperlipidemic effects, 8 Diuretic activity, 9 Cardioprotective effect, 10,11 Cytotoxic activity, 12 Antioxidant activity, [13][14][15][16] Antimicrobial activity, 17 Lipid-lowering and antioxidant activity, 18 hepatoprotective activity, 19 antinociceptive and antioxidant from root, 20 antithrombotic potential of the fruits.…”

Section: Sumitra Et Al:antioxidant Activity Of Lagenaria Sicerariamentioning

confidence: 99%

Antioxidant and metal chelating activities of Lagenaria siceraria (Molina) Standl peel, pulp and aerial parts in relation to their total phenol and flavonoid content

Chanda¹,

Moteriya²,

Padaliya³

et al. 2015

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Objective: The aim of the present study was to evaluate the antioxidant activity and total phenol and flavonoid content of different parts (peel, pulp and aerial parts) of Lagenaria siceraria. Method: Successive extraction was done by cold percolation method using solvents of different polarity viz. petroleum ether, toluene, ethyl acetate, acetone, water. Total phenol content was determined by Folin-Ciocalteu's reagent method and flavonoid was determined by aluminium chloride colorimetric method. The antioxidant assays evaluated were 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, 2, 2'-Azino-bis-(3-ethyl) benzothiazoline-6-sulfonic acid (ABTS) radical cation scavenging activity and Ferric reducing antioxidant power. Results: L. siceraria peel possessed maximum phenol and flavonoid content in acetone and toluene extracts respectively. FRAP was maximum in acetone extract of peel. The peel extract demonstrated stronger DPPH activity with IC 50 value of 111 µg/ml followed by pulp extract. The same extract was effective in scavenging ABTS radical with an IC 50 value of 39 µg/ml while other parts were ineffective. Conclusion: This work demonstrated good antioxidant activity of L. siceraria vegetable cultivated in India and recommends that the peel of this vegetable may be of interest from a functional point of view as a major source of natural antioxidant.

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Section: Sumitra Et Al:antioxidant Activity Of Lagenaria Sicerariamentioning

confidence: 99%

Antioxidant and metal chelating activities of Lagenaria siceraria (Molina) Standl peel, pulp and aerial parts in relation to their total phenol and flavonoid content

Chanda¹,

Moteriya²,

Padaliya³

et al. 2015

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“…The health promoting ability of these vegetables is attributed to the antioxidant properties of various phytochemicals present in them (Saha et al 2011). Studies have revealed the presence of a wide range of secondary metabolites including flavonoids, triterpenoid, saponins and phenolic acids in gourd vegetables possessing distinct biological activities (Rizvi et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of various extracts of selected gourd vegetables

Yadav

et al. 2016

J Food Sci Technol

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Study was conducted to evaluate the antioxidative activity of methanolic (ME), ethanolic (EE) and butanolic extracts (BE) of selected gourd vegetables. The antioxidant activity was investigated using different assays namely ferric thiocyanate test (FTC), thiobarbituric acid test (TBA), ferric reducing antioxidant power (FRAP) and DPPH free radicals scavenging test. A densitometric HPTLC analysis was performed for the analysis of phenolic acids and flavonoids. Different extracts of the selected gourd vegetables revealed different antioxidant activity. Different extracts of Lagenaria siceraria, Momordica charantia and Luffa cylindrica revealed significantly higher (p < 0.05) concentrations of total phenols, flavonids, tannins and carotenoids content and also the antioxidant activity in comparison to remaining vegetable extracts. Correlation studies indicated that FRAP test best described the antioxidant activity of phenols, flavonoids and carotenoids (r = 0.854, 0.692 and 0.915 respectively). HPTLC profiles revealed the presence of maximum number of phenolic acids and flavonoids in L. siceraria and M. charantia.

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“…One-fifth of the maximum safe dose of the extract tested for acute toxicity was selected for the subchronic toxicity study. [15][16][17][18] Thus, for further (subchronic) study of the extract effects on biochemical and histopathological parameters and also antioxidant status of the animals, 12 Wistar rats were randomly divided into two experimental groups each of six animals: group I which served as the control group, and group II which received 20% of the maximum tolerated dose (MTD) of the JRSME (1000 mg/kg bw) by gavage once a day for four weeks. At the same time, the control rats received with the same route of administration an equivalent volume of normal saline.…”

Section: Toxicity Studymentioning

confidence: 99%