Antioxidant and Hepatoprotective Activities of Polysaccharides from Spent Mushroom Substrates (Laetiporus sulphureus) in Acute Alcohol‐Induced Mice

Abstract

In order to contribute to the exploitation and utilization of spent mushroom substrates (SMS) of Laetiporus sulphureus, hot-water-extractable polysaccharides (H-SMPS) and enzymatic-extractable polysaccharides (E-SMPS) were successfully isolated from SMS of L. sulphureus. Both H-SMPS and E-SMPS were found to have high reducing power and potential scavenging activities against hydroxyl, DPPH, and superoxide anion radicals. In vivo assays showed that the administration of H-SMPS and E-SMPS has potential hepatoprotective effects against alcohol-induced alcoholic liver disease (ALD), possibly brought about by improving liver function, increasing antioxidant status, and reducing lipid peroxidation. Furthermore, monosaccharide composition analysis showed that fucose may play a vital role in guaranteeing stronger hepatoprotection. These results may provide references for the exploitation of the SMS of L. sulphureus as a source of H-SMPS and E-SMPS, which in turn can be used as functional foods or natural drugs for the prevention of ALD and other liver diseases.

Dendrobium officinale Flower Extraction Mitigates Alcohol‐Induced Liver Injury in Mice: Role of Antisteatosis, Antioxidative, and Anti‐Inflammatory

“…GSH-Px specifically catalyzes the reduction reaction of GSH to peroxides to block the chain reaction of lipid peroxidation [ 39 ]. Therefore, increasing those enzymatic and nonenzymatic antioxidants may be conducive to relieve alcohol-induced oxidative stress [ 5 , 40 ]. The results of this study demonstrated that DOFE could reduce the level of MDA and increase the activity of SOD, CAT, and GSH-PX activities and the GSH level.…”

Antioxidant and Hypoglycemic Effects of Acidic‐Extractable Polysaccharides from Cordyceps militaris on Type 2 Diabetes Mice

“…The scavenging activity towards DPPH radical was measured according to the method reported by Zhao et al [25]. The mixture including AE-PS (0.2 mL, 0–400 μ g/mL) and DPPH solution (0.6 mL, 0.004%, w / v in methanol) was disposed at the dark and still standing for 30 min.…”

Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage

“…For our experiment, the administration route, time of exposure, and dosage of the model established were decided by literature review, pre-experiments, and screens. One acute alcoholic liver injury model was established by the oral gavage route to cause mouse liver function loss so significant that it accords with human drinking habits, which avoided the shortcomings usually arising with intraperitoneal injections, such as organ adhesion, infection, and ascite formation (Wang et al, 2012;Zhao et al, 2017). However, the other acute liver injury model was induced by intraperitoneal CCl 4 injection of mice since the toxicant was absorbed quickly, and just one injection would bring an overall toxic response to animals.…”