Antioxidant and genoprotective properties of the antidiabetic drug metformin under X-ray irradiation

Karmanova, E. E.; Abdullaev, S. A.; Ivanov, V. E.; Minkabirova, G. M.; Брусков, В. И.

doi:10.1088/1757-899x/487/1/012023

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…In view of this, new radioprotective agents that are nontoxic and easy to administer are still urgently needed. Searching effective radioprotective agents among drugs that have been approved for the treatment of various diseases is a new strategy to develop prevention and treatment of different forms of radiation damage [ 5 ]. The biggest advantage of this strategy is that there is no need to consider the toxicity of the drug itself when using it at known therapeutic concentrations.…”

Section: Introductionmentioning

confidence: 99%

Pretreatment with metformin protects mice from whole-body irradiation

Guo

Yao

et al. 2021

Journal of Radiation Research

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Metformin, a first-line oral drug for type II diabetes mellitus, not only reduces blood glucose levels, but also has many other biological effects. Recent studies have been conducted to determine the protective effect of metformin in irradiation injuries. However, the results are controversial and mainly focus on the time of metformin administration. In this study, we aimed to investigate the protective effect of metformin in BALB/c mice exposed to 6 Gy or 8 Gy of a 60Co source of γ-rays for total body irradiation (TBI). Survival outcomes were assessed following exposure to 8 Gy or 6 Gy TBI, and hematopoietic damage and intestinal injury were assessed after exposure to 6 Gy TBI. Metformin prolonged the survival of mice exposed to 8 Gy TBI and improved the survival rate of mice exposed to 6 Gy TBI only when administered before exposure to irradiation. Moreover, pretreatment with metformin reduced the frequency of micronuclei (MN) in the bone marrow of mice exposed to 6 Gy TBI. Pretreatment of metformin also protected the intestinal morphology of mice, reduced inflammatory response and decreased the number of apoptotic cells in intestine. In conclusion, we demonstrated that pretreatment with metformin could alleviate irradiation injury.

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Section: Introductionmentioning

confidence: 99%