Antioxidant and DNA protective effects of NTX, a proprietary glycyrrhizin/ d -mannitol product, in association with alcohol consumption: A randomized, placebo-controlled, double-blind, crossover study

Antioxidant Properties of Flaxseed Protein Hydrolysates: Influence of Hydrolytic Enzyme Concentration and Peptide Size

“…The interaction of Fe 2+ and H 2 O 2 in the Fenton reaction results in the production of extremely volatile and transient hydroxyl radicals. This radical has been implicated in the oxidation of biological macromolecules (e.g., lipids, nucleic acids, and proteins) with the potential to trigger or contribute to the development and/or progression of chronic disease conditions (Chigurupati et al, ; Shibata et al, ; Treml & Šmejkal, ). Similar to the DPPH and superoxide radicals, GSH was a better scavenger of hydroxyl radicals than the FPH and peptide fractions (Fig.…”

“…These ROS possess the potential to induce oxidative damage to biological macromolecules that include lipids, proteins, and nucleic acids (Treml & Šmejkal, ). Left unchecked, especially during oxidative stress‐mediated depletion of natural cellular antioxidants, such radical‐mediated injury could eventually result in chronic degenerative and debilitating diseases like hypertension, atherosclerosis, aging, cancer, diabetes mellitus, and inflammation‐related tissue damage (Chigurupati et al, ; Erdmann, Cheung, & Schröder, ; Nabha, Garbern, Buller, & Charpie, ; Treml & Šmejkal, ). For example, toxic ROS cause a wide range of biological injury to low density lipoprotein (LDL) resulting in increased atherogenicity of oxidized LDL and could also trigger or contribute to the pathological progression of cancer, atherosclerosis, Alzheimer's disease, and diabetes among others (Erdmann et al, ; Shibata et al, ; Treml & Šmejkal, ).…”

Hepatopreventive properties of hydroxytyrosol and mannitol-rich extracts obtained from exhausted olive pomace using green extraction methods

“…42,47 Furthermore, the administration of AE-EOP and AAE-EOP extracts reduced DNA fragmentation in liver tissue, indicating that AE-EOP and AAE-EOP extract pre-treatment alleviated apoptosis by inhibited oxidative stress. Recent studies highlighted the anti-genotoxicity in liver tissue of the major metabolites in AE-EOP and AAE-EOP extracts, such as mannitol 48 and hydroxytyrosol. 49…”

“…Food & Function DNA fragmentation in liver tissue, indicating that AE-EOP and AAE-EOP extract pre-treatment alleviated apoptosis by inhibited oxidative stress. Recent studies highlighted the anti-genotoxicity in liver tissue of the major metabolites in AE-EOP and AAE-EOP extracts, such as mannitol 48 and hydroxytyrosol. 49 The present findings also revealed that CCl 4 induced perturbation of the lipid profile as observed by considerably increased levels either in plasma and hepatic tissue of TC, TG and LDL-C, while HDL-C levels decreased.…”