Antioxidant and cardioprotective activities of phenolic extracts from fruits of Chilean blackberry Aristotelia chilensis (Elaeocarpaceae), Maqui

Céspedes, Carlos L.; El-Hafidi, Mohammed; Pavón, Natalia; Alarcón, Julio

doi:10.1016/j.foodchem.2007.08.092

Cited by 177 publications

(145 citation statements)

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“…We found that it had a signifi cantly higher phenolic content than other fractions [(18.987 ± 755.9) µmol catechin equiv./g extract] (Céspedes et al, 2009). These fi ndings correlate well with our last fi ndings (Céspedes et al, 2008). Since this fraction had the greatest activity against TBARS formation, this can also be attributed to the occurrence of the 3-hydroxyindole derivative in this fruit.…”

Section: Resultssupporting

confidence: 87%

“…The DPPH radical scavenging assay was fi rst used as a screen for antioxidant components within the primary extracts (Céspedes et al, 2008). After HPLC analyses of the ethyl acetate extract fraction F-11 obtained at 24.5 min was collected and evaluated using the antioxidant assays.…”

Section: Resultsmentioning

confidence: 99%

“…3-Hydroxyindole, extracts and fractions of A. chilensis were examined for their antioxidant effects according to Céspedes et al (2008) and Domínguez et al (2005).…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Recently, we have published the antioxidant and cardioprotective activities of phenolic extracts from fruits of Chilean black berry (Céspedes et al, 2008), which have traditionally been consumed for the treatment of diarrhea and dysentery. Previously, we have reported the alkaloid composition of the leaves of Aristotelia chilensis (Céspedes et al, 1993;Silva et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Activity of an Unusual 3-Hydroxyindole Derivative Isolated from Fruits of Aristotelia chilensis (Molina) Stuntz

Céspedes

Alarcón

Valdez‐Morales

et al. 2009

Zeitschrift Für Naturforschung C

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3-Hydroxyindole was isolated from the EtOH extract of fruits of Aristotelia chilensis during analyses by HPLC/MS and GC/MS and identifi ed by its mass fragmentation pattern and spectrophotometric data. Additionally, this extract showed an interesting antioxidant activity in DPPH, crocin and TBARS assays. The presence of this type of compound in this fruit species permits us to explain its strong antioxidant activity and its important part in the biosynthetic pathway of phenolic and alkaloid compounds in this plant. Therefore this compound could be useful for the development of future nutraceutical and antioxidant protective agents.Key words: Hydroxyindole, Antioxidant Activity, Aristotelia chilensis IntroductionAnthocyanins, fl avonoids and phenolic acids are compounds which occur very often in many plant families. Their different biological activities, including antioxidant, antimicrobial, carcinogenic, cytotoxic, anti-infl ammatory and mutagenic properties, make them interesting objects of research (Middleton and Kandaswami, 1993). Recently, attenuation has been payed to the dietary indole amines melatonin and serotonin in different plant foods, including grapes and berries, thus further supporting the hypothesis that health benefi ts associated with Mediterranean dietary style are due to plant food chemical diversity (Iriti and Faoro, 2008). The presence of hydroxyindole in fruits tissues is relevant for their important biological activities. Additionally, the importance of indole moieties in the biosynthesis of phenolics is documented (Applewhite et al., 1994).We have under continuous study different extracts of edible fruits of southern Chile. Recently, we have published the antioxidant and cardioprotective activities of phenolic extracts from fruits of Chilean black berry (Céspedes et al., 2008), which have traditionally been consumed for the treatment of diarrhea and dysentery. Previously, we have reported the alkaloid composition of the leaves of Aristotelia chilensis (Céspedes et al., 1993;Silva et al., 1997). There are some reports about the antioxidant activity and a partial composition of anthocyanidins (Miranda-Rottman et al., 2002;Escribano-Bailon et al., 2006).In continuation of our search for more specifi c antioxidant activities, in the present paper we report the antioxidant activity of an unusual 3-hydroxyindole derivative and of a very interesting fraction obtained during a metabolomic analysis of fruits of A. chilensis. The occurrence of 3-hydroxyindole helps us to explain the antioxidant, chemopreventive, cardiopreventive, and anti-infl ammatory activities of this fruit. Material and Methods Plant materialPlants and fruits of Aristotelia chilensis (Molina) Stuntz (Elaeocarpaceae) were collected from fi elds at the foothills of Los Andes Mountains (900 m, 38°38'57'' S, 71°52'32'' W) on a track at the shore of "Quepe" lake, very near to "Conguillio" National Park, Cherquenco district, near Temuco City, Chile, in January 2006. The samples were identifi ed botanically by Professor Fernando Per...

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Section: Resultssupporting

confidence: 87%

Section: Resultsmentioning

confidence: 99%

“…3-Hydroxyindole, extracts and fractions of A. chilensis were examined for their antioxidant effects according to Céspedes et al (2008) and Domínguez et al (2005).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antioxidant Activity of an Unusual 3-Hydroxyindole Derivative Isolated from Fruits of Aristotelia chilensis (Molina) Stuntz

Céspedes

Alarcón

Valdez‐Morales

et al. 2009

Zeitschrift Für Naturforschung C

Self Cite

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“…Oxidative stress is defined as the exposure of living matter to various sources that produce the loss of balance between free radicals and antioxidants responsible for eliminating such chemical species, in favor of free radicals under aerobic conditions (Konigsberg, 2008 To counteract the effects of free radicals, cells produce their own antioxidant system (endogenous) through enzymes; the other way is the production of exogenous antioxidants by food intake ( Kinsella et al, 1993). It has been shown in clinical studies that the consumption of natural antioxidants of fruits and vegetables reduces the oxidative stress for example: extracts of apple with high content of polyphenols, similarly with nutritional supplements rich in antioxidants (Céspedes et al, 2008). Another example is the fruit of hawthorn (Crataegus mexicana) in which the antioxidant action of acetone and methanol extracts of the hawthorn shell has been evaluated as well as evaluation of the extract of hawthorn in the inhibition of lipoperoxidation in human erythrocytes (Banderas et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant evaluation of a fermented alcoholic beverage of hawthorn (Crataegus mexicana)

2017

Int. J. Adv. Res. Biol. Sci

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In nature there are antioxidant compounds that can inhibit the oxidation-reduction processes in the human organism, it is important to evaluate the role of the natural antioxidants that counteract those processes. Studies in vitro models have shown that the extracts of acetone derived from the shell of the hawthorn (Crataegus mexicana) have high antioxidant activity. After being subjected to a fermentation process, it preserves this biological property. The purpose of this work was to evaluate the antioxidant activity by colorimetric techniques as well as to identify some metabolites by HPLC-masses of the fermented beverage of hawthorn.The free radical trapping capacity of the hawthorn (C. mexicana), was determined using DPPH and ABTS.The fermentation was developed in two media, in natural environment and with Saccharomyces cerevisiae.The fermented beverage of hawthorn reached 12% Alc. Vol., The percentage of the antioxidant activity evaluated by the DPPH method reached 84 ± 3.6%, by ABTS 95.3 ± 3.3%. The metabolite identified in the fermented beverage of hawthorn has a mass ratio of 577 m/z corresponding to Procyanidin B 2 .Based on the above results, it is possible to mention that the hawthorn subjected to a biological fermentation process preserves the antioxidant activity.

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Antioxidants: Introduction

He¹,

Pan²,

Ji³

et al. 2012

Antioxidant Polymers

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Antioxidant and cardioprotective activities of phenolic extracts from fruits of Chilean blackberry Aristotelia chilensis (Elaeocarpaceae), Maqui

Cited by 177 publications

References 35 publications

Antioxidant Activity of an Unusual 3-Hydroxyindole Derivative Isolated from Fruits of Aristotelia chilensis (Molina) Stuntz

Antioxidant Activity of an Unusual 3-Hydroxyindole Derivative Isolated from Fruits of Aristotelia chilensis (Molina) Stuntz

Antioxidant evaluation of a fermented alcoholic beverage of hawthorn (Crataegus mexicana)

Antioxidants: Introduction

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