Antioxidant and bone healing effect of vitamin E in an experimental osteotomy model in dogs

Paskalev, M.; Goranov, N.; Krastev, S.; Roydev, R.

doi:10.1007/s00580-010-1011-8

Cited by 7 publications

(19 citation statements)

References 22 publications

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“…Besides that, another salient observation was the extreme heterogeneity of the study methods employed in the articles included in this paper. Of the six experimental-based animal studies published (Table 1), three studies were based upon the rat model [18, 21, 24], two were based upon the rabbit model [15, 23], and only one was based upon the dog model [8]. The bone model being investigated in the studies was primarily normal bone, except one study that focused on osteoporotic bone model [18].…”

Section: Resultsmentioning

confidence: 99%

“…The bone model being investigated in the studies was primarily normal bone, except one study that focused on osteoporotic bone model [18]. One of three types of fracture production procedure was generally used in these studies: osteotomy [8, 15], manual fracture [21, 23, 24], or 3-point bending method using a guillotine device [18]. Nearly all of the studies were based upon a secondary bone healing model promoted by either internal fixation using Kirschner wires [18, 21], external fixation [15, 23], or left in situ [24].…”

Section: Resultsmentioning

confidence: 99%

“…Nearly all of the studies were based upon a secondary bone healing model promoted by either internal fixation using Kirschner wires [18, 21], external fixation [15, 23], or left in situ [24]. Only one study was based upon primary bone healing model promoted by internal fixation using plates [8]. To date, there was no published study of the effect of tocotrienol analog on bone fracture healing.…”

Section: Resultsmentioning

confidence: 99%

“…Besides that, there was also heterogeneity in the main outcome measures of each study. These outcomes may be clustered into five major groupings: (a) radiological-based assessment of bone formation [8, 15, 18, 21]; (b) histological-based assessment of bone formation [15, 21, 23, 24]; (c) radiological-based assessment of callous volume/index [18, 24]; (d) radiological-based assessment of callous formation [8, 18]; (e) osteoblastic activity assessment [15]. …”

Section: Resultsmentioning

confidence: 99%

“…Based upon the initial background search on the issue at hand, the most popular proposed mechanism of action for the effect of vitamin E on bone fracture healing is based upon the cellular-protective property of antioxidant. In bone fracture, oxygen free radicals are produced by the activation of polymorphonuclear neutrophils in the inflammatory phase of bone fracture healing [7], as well as by the impairment of blood supply to the bone ends [8]. These free radicals have been shown to inhibit bone fracture healing [9, 10] by initiating a chain reaction that will cause lipid peroxidation that leads to cell membrane damage and eventually cell lysis [7].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin E and the Healing of Bone Fracture: The Current State of Evidence

Borhanuddin

Fozi

Mohamed

2012

Evidence-Based Complementary and Alternative Medicine

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Background. The effect of vitamin E on health-related conditions has been extensively researched, with varied results. However, to date, there was no published review of the effect of vitamin E on bone fracture healing. Purpose. This paper systematically audited past studies of the effect of vitamin E on bone fracture healing. Methods. Related articles were identified from Medline, CINAHL, and Scopus databases. Screenings were performed based on the criteria that the study must be an original study that investigated the independent effect of vitamin E on bone fracture healing. Data were extracted using standardised forms, followed by evaluation of quality of reporting using ARRIVE Guidelines, plus recalculation procedure for the effect size and statistical power of the results. Results. Six animal studies fulfilled the selection criteria. The study methods were heterogeneous with mediocre reporting quality and focused on the antioxidant-related mechanism of vitamin E. The metasynthesis showed α-tocopherol may have a significant effect on bone formation during the normal bone remodeling phase of secondary bone healing. Conclusion. In general, the effect of vitamin E on bone fracture healing remained inconclusive due to the small number of heterogeneous and mediocre studies included in this paper.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin E and the Healing of Bone Fracture: The Current State of Evidence

Borhanuddin

Fozi

Mohamed

2012

Evidence-Based Complementary and Alternative Medicine

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Advances and Promises of Nutritional Influences on Natural Bone Repair

Roberts

Drissi

2019

Journal Orthopaedic Research

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Impaired fracture healing continues to be a significant public health issue. This is more frequently observed in aging populations and patients with co‐morbidities that can directly influence bone repair. Tremendous progress has been made in the development of biologics to enhance and accelerate the healing process; however, side‐effects persist that can cause significant discomfort and tissue damage. This has been the impetus for the development of safe and natural strategies to hasten natural bone healing. Of the many possible approaches, nutrition represents a safe, affordable, and non‐invasive strategy to positively influence each phase of fracture repair. However, our understanding of how healing can be hindered by malnutrition or enhanced with nutritional supplementation has lagged behind the advancements in both surgical management and the knowledge of molecular and cellular drivers of skeletal fracture repair. This review serves to bridge this knowledge gap as well as define the importance of nutrition during fracture healing. The extant literature clearly indicates that pre‐existing nutritional deficiencies should be corrected, and nutritional status should be carefully monitored to prevent the development of malnutrition for the best possible healing outcome. It remains unclear, however, whether the provision of nutrients beyond sufficiency has any benefit on fracture repair and patient outcomes. The combined body of pre‐clinical studies using a variety of animal models suggests a promising role of nutrition as an adjuvant therapy to facilitate fracture repair, but extensive research is needed, specifically at the clinical level, to clarify the utility of nutritional interventions in orthopedics. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:695‐707, 2020

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