Antioxidant and Antitumor Activities of Cultured Mycelium of Culinary-Medicinal Paddy Straw Mushroom Volvariella volvacea (Bull.: Fr.) Singer (Agaricomycetideae)

Mathew, John Tsado; Sudheesh, Naraycinci P.; Rony, Kuttikkadan A.; Smina, T P; Jananrdhanan, Kainoor K.

doi:10.1615/intjmedmushr.v10.i2.40

Cited by 15 publications

(17 citation statements)

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“…Cheung and Cheung (2005) found the most active fractions were obtained using the apolar organic solvent dichloromethane, while the higher antioxidant activity was observed for polar solvents such as water and ethanol in the studies of Cheung et al (2003) and Fu et al (2002). One study on the in vitro mycelia of V. volvacea showed the aqueous-ethanol extract possessed significant antioxidant and antitumor properties (Mathew et al 2008), although the authors did not research the antimicrobial potential of the cultures. The present study showed the antimicrobial fractions and subfractions active against S. aureus were mainly of apolar nature.…”

Section: Discussionmentioning

confidence: 99%

Study on the scavenging and anti-Staphylococcus aureus activities of the extracts, fractions and subfractions of two Volvariella volvacea strains

Silva

Barros

Pletsch

et al. 2010

World J Microbiol Biotechnol

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Scavenging and anti-Staphylococcus aureus activities of extracts, fractions and subfractions from the in vitro mycelium of two strains of the edible mushroom Volvariella volvacea were determined. Chloroform subfractions of the ATCC62890 strain showed the highest inhibition percentage of the DPPH radical (over 80%) after 180 min. When chloroform and hexane subfractions of the R83 strain were combined they showed moderate (inhibition zone of 8.99 ± 0.78 mm) to high (inhibition zone of 13.06 ± 0.41 mm) activity against the Gram-positive bacteria Staphylococcus aureus, which are 74.4 and 51.2% of tetracycline (inhibition zone of 17.55 ± 0.11 mm). Partitioning suggested that the substances in the chloroform and hexane fractions of the R83 strain act synergistically to give the antimicrobial activity, while separating the substances of the ATCC62890 subfractions reduced their activity. In general, the R83 strain seems to be a source of antimicrobial substances, while the ATCC62890 strain appears to be an alternative source of antioxidants.

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Section: Discussionmentioning

confidence: 99%

Study on the scavenging and anti-Staphylococcus aureus activities of the extracts, fractions and subfractions of two Volvariella volvacea strains

Silva

Barros

Pletsch

et al. 2010

World J Microbiol Biotechnol

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show abstract

“…Mushrooms have been appreciated for their flavors, economic value, ecological value, and medicinal properties for many years [ 1 ]. Many therapeutic effects have been reported for medicinal mushrooms such as anti-inflammatory [ 2 ], antitumor [ 3 – 5 ], anticancer and immunomodulatory effects [ 6 , 7 ]; stimulating macrophage activity and anti-hepatitis B virus activity [ 8 ]; and anti-oxidative activities [ 9 – 12 ]. Phellinus igniarius (L.) Quélis, a basidiomycetous fungus belonging to the Hymenochaetaceae, has traditionally been used as a folk medicine due to its high biological activity [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Polyphenol Extract from Phellinus igniarius Protects against Acrolein Toxicity In Vitro and Provides Protection in a Mouse Stroke Model

et al. 2015

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The basidiomycetous mushroom Phellinus igniarius (L.) Quel. has been used as traditional medicine in various Asian countries for many years. Although many reports exist on its anti-oxidative and anti-inflammatory activities and therapeutic effects against various diseases, our current knowledge of its effect on stroke is very limited. Stroke is a neurodegenerative disorder in which oxidative stress is a key hallmark. Following the 2005 discovery by Igarashi’s group that acrolein produced from polyamines in vivo is a major cause of cell damage by oxidative stress, we now describe the effects of anti-oxidative extracts from P. igniarius on symptoms of experimentally induced stroke in mice. The toxicity of acrolein was compared with that of hydrogen peroxide in a mouse mammary carcinoma cell line (FM3A). We found that the complete inhibition of FM3A cell growth by 5 μM acrolein could be prevented by crude ethanol extract of P. igniarius at 0.5 μg/ml. Seven polyphenol compounds named 3,4-dihydroxybenzaldehyde, 4-(3,4-dihydroxyphenyl-3-buten-2one, inonoblin C, phelligridin D, inoscavin C, phelligridin C and interfungin B were identified from this ethanolic extract by LCMS and 1H NMR. Polyphenol-containing extracts of P. igniarius were then used to prevent acrolein toxicity in a mouse neuroblastoma (Neuro-2a) cell line. The results suggested that Neuro-2a cells were protected from acrolein toxicity at 2 and 5 μM by this polyphenol extract at 0.5 and 2 μg/ml, respectively. Furthermore, in mice with experimentally induced stroke, intraperitoneal treatment with P. igniarius polyphenol extract at 20 μg/kg caused a reduction of the infarction volume by 62.2% compared to untreated mice. These observations suggest that the polyphenol extract of P. igniarius could serve to prevent ischemic stroke.

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“…Mushrooms are very important resources of antioxidants and antitumor activity researches. Many therapeutic evidences have been reported for medicinal mushrooms such as antitumor (Monro 2003; Lee and others 2006; Mathew and others 2008), anticancer and immune‐stimulatory effects (Wasser and Weiss 1999), immunomdulatory effect (Kuo and others 2006), stimulating macrophage activity and anti‐hepatitis B virus activity (Lee and others 2002), and free‐radical scavenging (Mau and others 2002a, 2002b; Tsai and others 2008). Antioxidant activity is one important bioactivity assayed from mushrooms.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant Properties of Edible Basidiomycete Phellinus igniarius in Submerged Cultures

Lung

Tsai

Huang

2010

Journal of Food Science

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Antioxidant and Antitumor Activities of Cultured Mycelium of Culinary-Medicinal Paddy Straw Mushroom Volvariella volvacea (Bull.: Fr.) Singer (Agaricomycetideae)

Cited by 15 publications

References 0 publications

Study on the scavenging and anti-Staphylococcus aureus activities of the extracts, fractions and subfractions of two Volvariella volvacea strains

Study on the scavenging and anti-Staphylococcus aureus activities of the extracts, fractions and subfractions of two Volvariella volvacea strains

Polyphenol Extract from Phellinus igniarius Protects against Acrolein Toxicity In Vitro and Provides Protection in a Mouse Stroke Model

Antioxidant Properties of Edible Basidiomycete Phellinus igniarius in Submerged Cultures

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