Antioxidant and antiradical properties of new amino-acid derivatives of aminoalcohols

Abstract

The antioxidant, antiradical, and membranotropic properties of newly synthesized compounds of the group of N-[3-hydroxy-3-(p-substituted phenyl)-1-propyl] amino acids were studied on model systems in vitro. According to the results, amino-acid derivatives of aminopropanols did not exhibit any significant antioxidant or antiradical activity as evidenced by Fe(II)-stimulated ascorbate-dependent peroxidation, by spectrophotometric monitoring of a decrease in the concentration of stable 2,2-diphenyl-1-picrylhydrazyl radical, or by photochemiluminescence techniques. However, these compounds revealed a membrane-stabilizing effect preventing hemolytic destruction of cells under conditions of H 2 O 2 -stimulated oxidative stress of erythrocytes. In this respect, derivatives of glycine, leucine, and methionine were most interesting.

Antioxidant, Cytotoxicity, and Stability Evaluation of Ginkgo Biloba Extract-Based Microemulsions for Enhanced Therapeutic Activity

“…Furthermore, reduction in ABTS and DPPH free radicals due to the antiradical compounds (EGB761 and GBME) was estimated further at the above-mentioned wavelengths [26,27]. AA (10-50 µg/ml) was used as a standard and scavenging effect of test samples (%) were calculated as [28]:…”