Antioxidant and antineoplastic activities of methanolic extract of Kaempferia galanga Linn. Rhizome against Ehrlich ascites carcinoma cells

Ali, Hanif; Yesmin, Rumana; Satter, Mohammed A.; Habib, Rowshanul; Yeasmin, Tanzima

doi:10.1016/j.jksus.2017.05.009

Cited by 35 publications

(35 citation statements)

References 34 publications

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“…Acetone, petroleum ether, chloroform, and MeOH extracts of K. galanga rhizomes show moderate cytotoxicity in a brine shrimp lethality bioassay compared with vincristine sulfate as the reference compound [19]. Moreover, a methanolic extract of K. galanga rhizomes induces Ehrlich ascites carcinoma (EAC) cell death in a dose-dependent manner [20]. 5,7-Dimethoxyflavone ( 86 ) isolated from K. galanga was found to reduce cancer resistance to tyrosine kinase inhibitors (TKI) by inhibiting breast cancer resistance protein (BCRP), one of the efflux transporters that increased efflux of TKI out of cancer cells.…”

Section: Biological Activitymentioning

confidence: 99%

“…Also, kaempfolienol ( 65 ) showed potent free radical scavenging activity in a DPPH assay, as well as, 2′-hydroxy-4,4′,6′-trimethoxychalcone ( 119 ) in ABTS, CUPRAC, and FRAP assays [33,34]. A methanol extract of rhizomes of K. galanga exhibited a concentration-dependent antioxidant activity in DPPH, ABTS, and nitric oxide (NO) radical scavenging assays [20]. Moreover, the essential oil extracts of conventionally propagated and in vitro propagated K. galanga had significant DPPH radical scavenging activity [35].…”

Section: Biological Activitymentioning

confidence: 99%

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Recent Advances in Kaempferia Phytochemistry and Biological Activity: A Comprehensive Review

et al. 2019

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Background: Plants belonging to the genus Kaempferia (family: Zingiberaceae) are distributed in Asia, especially in the southeast region, and Thailand. They have been widely used in traditional medicines to cure metabolic disorders, inflammation, urinary tract infections, fevers, coughs, hypertension, erectile dysfunction, abdominal and gastrointestinal ailments, asthma, wounds, rheumatism, epilepsy, and skin diseases. Objective: Herein, we reported a comprehensive review, including the traditional applications, biological and pharmacological advances, and phytochemical constituents of Kaempheria species from 1972 up to early 2019. Materials and methods: All the information and reported studies concerning Kaempheria plants were summarized from library and digital databases (e.g., Google Scholar, Sci-finder, PubMed, Springer, Elsevier, MDPI, Web of Science, etc.). The correlation between the Kaempheria species was evaluated via principal component analysis (PCA) and agglomerative hierarchical clustering (AHC), based on the main chemical classes of compounds. Results: Approximately 141 chemical constituents have been isolated and reported from Kaempferia species, such as isopimarane, abietane, labdane and clerodane diterpenoids, flavonoids, phenolic acids, phenyl-heptanoids, curcuminoids, tetrahydropyrano-phenolic, and steroids. A probable biosynthesis pathway for the isopimaradiene skeleton is illustrated. In addition, 15 main documented components of volatile oils of Kaempheria were summarized. Biological activities including anticancer, anti-inflammatory, antimicrobial, anticholinesterase, antioxidant, anti-obesity-induced dermatopathy, wound healing, neuroprotective, anti-allergenic, and anti-nociceptive were demonstrated. Conclusions: Up to date, significant advances in phytochemical and pharmacological studies of different Kaempheria species have been witnessed. So, the traditional uses of these plants have been clarified via modern in vitro and in vivo biological studies. In addition, these traditional uses and reported biological results could be correlated via the chemical characterization of these plants. All these data will support the biologists in the elucidation of the biological mechanisms of these plants.

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Section: Biological Activitymentioning

confidence: 99%

Section: Biological Activitymentioning

confidence: 99%

Recent Advances in Kaempferia Phytochemistry and Biological Activity: A Comprehensive Review

et al. 2019

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“…Rhizomes: The rhizomes contain monoterpenoids, sesquiterpenoids, and phenylpropanoids (Liu et al 2014). The volatile oil from rhizome contains ethyl-trans-p-methoxycinnamate and trans-ethyl cinnamate (Tewtrakul et al 2005;Raina and Abraham 2015), methylcinnamate, carvone, eucalyptol, and pentadecane (Tewtrakul et al 2005), 2-propenoic acid, 3-(4-methoxyphenyl), ethyl ester, phthalic acid, 6-ethyloct-3-yl2-ethylhexyl ester, palmitate acid, sandaracopimaradiene, oleate acid, oktadekanoate acid, 2-[2-(4-nonylphenoxy)ethoxy]ethanol, and glycidyl stearate (Ali et al (2018). Tricyclene, α-pinene, camphene, δ-3-carene, β-cymene, 1,8-cineole, chrysanthenone, transpinocarveol, camphor, borneol, p-cymen-8-ol, eucarvone, p-anisaldehyde, transcinnamaldehyde, bornyl acetate, sabinyl acetate, α-copaene, cyperene, ɤ-elemene, trans-ethyl cinnamate, ethyl cinnamate, ɤ-muurolene, δ-cadinene, calamenene, spathulenol, caryophyllene oxide, zierone, and ethyl p-methoxycinnamate are reported from rhizome essential oil (Liu et al 2014).…”

Section: Phytochemistrymentioning

confidence: 99%

“…K. galanga shows antineoplastic activity against Ehrlich Ascites Carcinoma (EAC) cells in vivo (Ali et al 2018), and its ethanol extract showed toxicity to human carcinoma cells (HeLa) (CD 50 10-30% μg/ml) (Ibrahim 1999). Ethyl-pmethoxycinnamate (EPMC) has antiangiogenic (Umar et al 2012), antibacterial, and antituberculosis properties (Lakshmanan et al 2011).…”

Section: Phytochemistrymentioning

confidence: 99%

Kaempferia galanga L. Zingiberaceae

Silalahi

2020

Ethnobotany of Mountain Regions

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Botany and Ecology Description: Rhizomes pale green or greenish white inside, tuberous, fragrant. Leaves usually 2-3(À5) sheaths 1.5-5 cm long, blade often horizontal and appressed to the soil, broadly elliptical to suborbicular, 6-15 cm Â 2(À5)-10 cm, acuminate, glabrous above, arachnoid-hairy below. Inflorescences terminal on pseudostems, enclosed by imbricate leaf sheaths, sessile, few to many flowered, bracts lanceolate 2.5 cm long. Calyx equaling bracts 2-3 cm long, corolla white, tube 2.5-5 cm long, lobes 1.5-3 cm long halfway or more, white or pale purple with violet to purple spot at base, each lateral lobe about 2-2.5 cm Â 1.5-2 cm long, other staminodes oblongobovate to oblanceolate, 1.5-3 cm long, white fertile stamen 10-13 cm long, connective deeply bilobed with reflexed lobes. Anther sessile; connective appendage strongly reflexed, rectangular, 2-lobed (Ibrahim 1999; Delin and Larsen 2000) (Figs. 1 and 2). Distribution and Habitat: K. galanga thrives best in slightly shaded places such as open forest edges, and bamboo forest on various soils up to 1000 m altitude (Ibrahim 1999

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“…As reported, these bioactive substances have exhibited antioxidant, sedative, antitumor, anti-inflammatory, and antimicrobial activities [7], which would contribute to the application on curing many diseases. The methanol extract of Kaempferia galanga L. rhizome significantly reduced viable Ehrlich ascites carcinoma (EAC) cells and weight gain, increased life span, and restored all hematological parameters, such as RBC, WBC, and hemoglobin of EAC-bearing mice towards normal level [8]. In addition, the ethanolic extract of Kaempferia galanga L. rhizome, ethyl-p-methoxycinnamate, exhibited promising anticholangiocarcinoma activity in CL6-xenografed nude mice as determined by significant inhibitory activity on tumor growth and lung metastasis, as well as prolongation of survival time [5], which could inhibit the proliferation of human hepatocellular liver carcinoma cells in a dose-dependent manner by inducing cells to enter into apoptosis [6].…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization and Antitumor Activity of Polysaccharides from Kaempferia galanga L.

Yang

Feng

et al. 2018

Oxidative Medicine and Cellular Longevity

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The water-soluble polysaccharides from Kaempferia galanga L. (KGPs) were extracted and purified, and their structural characteristics and antitumor activity were further investigated. The UV spectrum, high-performance gel permeation chromatography (HPGPC), Fourier-transform infrared spectroscopy (FTIR), and ion chromatography (IC) were employed to evaluate the structural characteristics, and H22 tumor-bearing mice model was established to demonstrate the antitumor activity. Physicochemical analysis and UV spectrum results showed that the proportions of total sugar, protein, and uronic acid in KGPs were 85.23%, 0.54%, and 24.17%, respectively. HPGPC, FTIR, and IC indicated that KGPs were acidic polysaccharides with skeletal modes of pyranose rings and mainly composed of arabinose and galactose with the average molecular weight of 8.5 × 105 Da. The in vivo antitumor experiments showed that KGPs could effectively protect the thymus and spleen of tumor-bearing mice from solid tumors and enhance the immunoregulatory ability of CD4+ T cells, the cytotoxic effects of CD8+ T cells and NK cells, and finally resulting in the inhibitory effects on H22 solid tumors. This study provided a theoretical foundation for the practical application of KGPs in food and medical industries.

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Antioxidant and antineoplastic activities of methanolic extract of Kaempferia galanga Linn. Rhizome against Ehrlich ascites carcinoma cells

Cited by 35 publications

References 34 publications

Recent Advances in Kaempferia Phytochemistry and Biological Activity: A Comprehensive Review

Recent Advances in Kaempferia Phytochemistry and Biological Activity: A Comprehensive Review

Kaempferia galanga L. Zingiberaceae

Structural Characterization and Antitumor Activity of Polysaccharides from Kaempferia galanga L.

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