Antioxidant and antimicrobial properties of 2-(4,5-dihydro-1H-pyrazol-1-yl)-pyrimidine and 1-carboxamidino-1H-pyrazole derivatives

Abstract

Cinco derivados de 4-trifluorometil-2-(5-aril-3-stiril-1H-pirazol-1il)-pirimidinas e seis 5-aril-3-estiril-1-carboxamidino-1H-pirazois previamente sintetizados foram avaliados de acordo com suas propriedades antioxidantes e antimicrobianas. Estas atividades foram avaliadas por ensaios de DPPH e HRP/luminol/H 2 O 2 quimioluminescência e suas atividades antimicrobianas (CIM). Os resultados foram bons para alguns compostos da série em certas concentrações em comparação direta com padrões.Five previously synthesized 4-trifluoromethyl-2-(5-aryl-3-styryl-1H-pyrazol-1yl)-pyrimidines and six 5-aryl-3-styryl-1-carboxamidino-1H-pyrazole derivatives were screened for their antioxidant proprieties. The antioxidant activities were evaluated by using the DPPH and the HRP/luminol/H 2 O 2 chemiluminescence assay systems and for their antimicrobial activity (MIC). The results were good for those series in some concentration in comparison with the standards.

Characterization of volatile composition of Laurencia dendroidea by gas chromatography-mass spectrometry

“…The antimicrobial and antioxidant activities were done as previously described (Gressler et al, 2010;.…”

Synthesis and antimicrobial activity of some 2- Piperidinomethylamino-4-(7-H/substituted coumarin-3-yl)- 6-chlorosubstitutedphenyl pyrimidines

“…Pyrimidine derivatives have an important place in medicinal chemistry as these are associated with a broad range of biological activities [2][3][4][5][6][7] including antimicrobial activity [8][9][10][11][12][13]. The clinical importance of pyrimidine nucleus is also evident by the marketing of clinically used pyrimidine derivatives as well as fused pyrimidine derivatives; for example, as antineoplastic agent (tegafur), as vasodilator (dipyridamole), as expectorant (tasuldine) and as antibacterial agent (trimethoprim, piromidic acid, tetroxoprim, metioprim), as antifungal agent (flucytosine), and as antiviral agent (broxuridine, idoxuridine) [14].…”

Crystal structure of [3,5-dimethyl-4-(prop-2-ynyl)-1Hpyrazol- 1-yl](2-furyl)methanone, C13H12N2O2

“…Derivatives of pyrazoles represent one of the most active classes of compounds possessing aw ide spectrum of biological activities, such as antibacterial [1,2], antimicrobial [3][4][5][6], antiviral [7], antioxidant [8],a nti-inflammatory [9,10], anticonvulsant [11,12], anticancer [13], anesthetic and anti-arrhythmic activities [14].T he formation of the title compound is the result of intramolecular ring closure of intermediate N'-(3-acetylhex-5-yn-2-ylidene)furan-2-carbohydrazide obtained as the main product in the absence of PTSA. But the N'-(3-acetylhex-5-yn-2-ylidene)furan-2-carbohydrazide maybealso isomerized to N'-(3-acetylhex-2-en-5-yn-2-yl)furan-2-carbohydrazide.…”