Antioxidant and antimicrobial activities of aporphinoids and other alkaloids from the bark of<i>Annona salzmannii</i>A. DC. (Annonaceae)

Costa, Emmanoel V.; Cruz, Pedro Ernesto Oliveira da; Lourenço, Caroline Caramano de; Moraes, Valéria Regina de Souza; Nogueira, Paulo César de Lima; Salvador, Marcos José

doi:10.1080/14786419.2012.688044

Cited by 55 publications

(45 citation statements)

References 7 publications

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“…Among the tested compounds, 170 exhibited the best activity with MIC values of 0.2 and 0.3 μM against E. coli and E. luteus , respectively, while 167 and 169 showed the weakest activity with MIC values of 2.6 μM against E. coli and 10.5 μM against E. luteus . The benzo[g]quinoline‐5,10‐dione cleistopholine ( 171 ) (Figure ) from the fruiting tree Annona salzmannii showed significant antibacterial activity (MIC 250 μg/mL) against S. epidermidis , E. faecalis , and Candida dubliniensis …”

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

“…The nitrogen oxide group was essential for the activity, as well as the length of the alkyl chain. The oxygen radical absorbance capacity (ORAC) value of cleistopholine, a quinoline alkaloid found in A. salzmannii , was 0.25 relative trolox equivalents …”

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

“…The oxygen radical absorbance capacity (ORAC) value of cleistopholine, a quinoline alkaloid found in A. salzmannii, was 0.25 relative trolox equivalents. 125 In 2015, Popv et al investigated the antioxidant and membranotropic activities of the quinazoline alkaloid tryptantrin (triptantrin from orginal paper) in different model systems. 193,194 Tryptanthrin exhibited very weak antioxidant activity, 1000 times lower than that of trolox, a vitamin E water-soluble analog commonly used an antioxidative benchmark, and 3000 times lower than that of the bioflavonoid dihydroquercetin.…”

Section: Effect On Ache and Bchementioning

confidence: 99%

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Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

151

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To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009-2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti-inflammatory, hepatoprotective, antioxidant, anti-asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

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Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

Section: Effect On Ache and Bchementioning

confidence: 99%

See 1 more Smart Citation

Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

151

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“…Gayle et al, [34] and Hadden et al, [35] had also reported that T. erecta flowers are rich in flavonoids, alkaloids and glycosides. Plants rich in phytoconstituents like alkaloids, flavonoids, tannins, terpenoids and steroids have antibacterial properties [36,37]. In addition, secondary metabolites such as tannins and other compounds of phenolic nature are also classified as active antimicrobial compounds [38].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Antimicrobial Efficacy of Different Solvent Extracts of Tagetes erecta L. Flower, Alone and in Combination with Antibiotics

Padalia¹,

Ch²

2015

Appli Micro Open Access

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Bacteria have evolved numerous defences against antimicrobial agent and drug resistance in pathogen is on rise. This is due to rapid development of multi-drug resistance, limited anti-bacterial spectrum and adverse effects of available anti-microbial agents. This necessitates the search for new antimicrobials with diverse structures and novel mechanism of action. Flowers are mostly used for ornamental purposes and they are not frequently worked out hence marigold flower was selected for the study. The antimicrobial activity of different solvent (Hexane, Toluene, Ethyl acetate, Acetone, Methanol and Aqueous) extracts of marigold flowers were evaluated by agar well diffusion method against a panel of pathogenic microorganisms. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of acetone extract and its fraction were evaluated. B. cereus and K. pneumonia were the most sensitive organisms to acetone extract and minimum inhibitory concentration (MIC) was 78 µg/ml. Synergistic effect of acetone extract and commercial antibiotics (chloroamphenicol and ceftazidime) against pathogenic bacteria was investigated. The best synergistic activity was with combination of acetone extract and ceftazidime against B. subtilis and P. aeruginosa with FIC indices 0.312 and 0.093 respectively. Only the polar solvent acetone extract showed promising antibacterial and synergistic activity. These results indicate that combination between plant extract and the antibiotics could be useful in fighting emerging drug-resistant microorganisms and choice of the solvent plays a prominent role in evaluating antimicrobial activity of medicinal plants. Flowers can be taken as an alternative source of antimicrobial agent against the human pathogens.

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“…Therefore, it may be concluded that antioxidative belongings resulted are due to qualitative and quantitative presence of phenolic groups in their structures. The alkaloid asimilobine isolated from bark of Annona salzmannii has showed two and half fold more oxygen radical absorbance capacity than trolox, due to the phenolic hydroxyl group [26] .…”

Section: Resultsmentioning

confidence: 99%

Reactive Species Metabolism and Cytotoxicity of Tribulus terrestris L. Alkaloid Extracts in Leukemic Cell Line

Basaiyye¹,

Bafana²,

Naoghare³

et al. 2018

pharmaceutical-sciences

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Basaiyye et al.: Cytotoxic Nature of Antioxidant Alkaloid Extracts of Tribulus terrestris L. FruitsThe present communication dealt with cytotoxic and free radical scavenging potential of tertiary and quaternary alkaloid extracts of Tribulus terrestris fruits. Tertiary and quaternary alkaloid extracts were found to be cytotoxic to leukemic cells (Jurkat E6-1) with LC 50 values of 100 and 42 µg/ml, respectively. Compared to the control, reactive oxygen species and reactive nitrogen species were significantly reduced in the cells treated with lower concentrations of tertiary and quaternary alkaloid extracts. Cells treated with tertiary alkaloid extract demonstrated significantly elevated levels of peroxidise, catalase and superoxide dismutaselike activities, whereas cells treated with quaternary alkaloid extracts showed insignificant elevations of the tested enzyme activities, compared to the control cells. The antioxidant activity of tertiary alkaloid (100 µg/ml) extract was 46.78 and 14.92 µg/ml of ascorbic acid equivalent as estimated in ferric reducing antioxidant potential and total antioxidant assays. Quaternary alkaloid extract displayed an IC 50 value of 159 µg/ml in the nitric oxide mitigation assay. Cells treated with quaternary alkaloid extracts showed 1.4-fold increase in superoxide dismutase-like activity compared to the control cells. These results suggest that tertiary and quaternary alkaloid extracts possessed cytotoxic and free radical scavenging potential against leukemic cells.

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Antioxidant and antimicrobial activities of aporphinoids and other alkaloids from the bark ofAnnona salzmanniiA. DC. (Annonaceae)

Cited by 55 publications

References 7 publications

Biologically active quinoline and quinazoline alkaloids part II

Biologically active quinoline and quinazoline alkaloids part II

Antimicrobial Efficacy of Different Solvent Extracts of Tagetes erecta L. Flower, Alone and in Combination with Antibiotics

Reactive Species Metabolism and Cytotoxicity of Tribulus terrestris L. Alkaloid Extracts in Leukemic Cell Line

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