ANTIOXIDANT AND ANTIDIABETIC POTENTIALS OF Cucurbita pepo LEAVES EXTRACT FROM THE GULF REGION

Chigurupati, Sridevi; AlGobaisy, Y.K.; Alkhalifah, B.; Alhowail, Ahmad; Bhatia, Saloni; Das, Shampa; Vijayabalan, Shantini

doi:10.31788/rjc.2021.1446455

Cited by 3 publications

(2 citation statements)

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“…The extract of C. pepo leaves exhibited a promising ability to inhibit α-amylase, with an IC 50 value of 24.99 ± 0.07 μg/mL, when compared to acarbose, the standard drug, which had an IC 50 value of 19.45 ± 0.19 µg/mL. Further, C. pepo leaves extract showed α-glucosidase inhibitory potential exhibiting IC 50 : 22.29 ± 0.27 μg/mL, whereas acarbose showed an IC 50 equal to 16.70 ± 0.09 μg/mL (Chigurupati et al, 2021). Liang et al (2021) confirm the antioxidant and ACE inhibitory activities of protein hydrolysate extracted from pumpkin seeds.…”

Section: In Vitro Hypoglycemic Potentialmentioning

confidence: 91%

Pumpkin seeds and leaves as an alternative medicine for the treatment of hyperglycemia

Isara,

Gunathilaka

2023

UCR

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Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to unhealthy dietary patterns, sedentary lifestyle behavior, and obesity. Among the two types of diabetes, type 2 is the most common in the world and the drugs used to treat hyperglycemia in type 2 DM cause adverse side effects. Hence, it is important to search for an effective natural anti-diabetic treatment to combat hyperglycemia and its complications in diabetic patients. Among the different herbal plants, pumpkin is very popular in terms of reducing blood glucose levels. Pumpkin is a popular vegetable cultivated all over the world and a rich source of bioactive compounds including phenolic compounds, unsaturated fatty acids, vitamin E and carotenoids. Currently, considerable attention is given to the seeds, leaves, and flesh of pumpkins due to their nutritional value and health benefits. However, this article focuses on the potency of pumpkin seeds and leaves to treat hyperglycemia.

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Section: In Vitro Hypoglycemic Potentialmentioning

confidence: 91%

Pumpkin seeds and leaves as an alternative medicine for the treatment of hyperglycemia

Isara,

Gunathilaka

2023

UCR

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“…C. pepo , also known as pumpkin, has been studied for its pharmacological actions. Here are some of the pharmacological activities of C. pepo based on the search results: hepatoprotection, 19 inhibition of benign prostatic hyperplasia, 20 antioxidant, 21 anticancer, 22 antimicrobial, 23 anti-inflammatory, 24 antidiabetic, 25 and antiulcer. 26 This research was conducted to determine whether or not the C. pepo extract has the ability to scavenge free radicals in vitro , as well as its anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

Assessment of In Vitro Antioxidant and Anti-Inflammatory Activities of Pumpkin (Cucurbita pepo) Natural Plant

Fathima,

Firdous,

Pal

et al. 2024

Natural Product Communications

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Objectives The objective of this research was to investigate the potential anti-inflammatory properties of the Cucurbita pepo fruit. Given the adverse effects associated with long-term use or excessive doses of conventional anti-inflammatory medications, exploring herbal therapies as alternatives has become increasingly important. Methods Various preliminary tests and antioxidant assays, both enzymatic and non-enzymatic, were conducted on the C . pepo fruit. Bioactive substances present in the fruit, including alkaloids, carbohydrates, flavonoids, tannins, amino acids, triterpenoids, and saponin glycosides, were identified through early analysis. Different extraction solvents, such as chloroform, methanol, and water, were utilized to extract samples. The methanolic extract was subjected to further testing for its in vitro anti-inflammatory characteristics. This involved evaluating their ability to stabilize RBC membranes, inhibit protein denaturation, and suppress proteinase activity using two concentrations (150 µg/ml and 300 µg/ml) of the extract. Results The methanolic extract of the C. pepo fruit exhibited strong free radical scavenging activity in both DPPH and H2O2 assays. Moreover, it demonstrated the dose-dependent stabilization of RBC membranes, resulting in reduced hemolysis, protein denaturation, and proteinase activity. These findings suggest potent anti-inflammatory effects of the methanolic extract. Conclusion This research study has found that the C. pepo fruit methanolic extract significantly reduced inflammation. This demonstrates the promise of natural chemicals as less risky substitutes for traditional anti-inflammatory medications. Potentially safe and efficient treatments for inflammatory illnesses could be found in herbal remedies such as the C. pepo fruit. Therefore, this study highlights the significance of exploring herbal remedies as a potential treatment option for inflammation-related diseases.

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Antimicrobial and antioxidant properties of the acetone extracts of the leaves of Lagenaria siceraria and Cucurbita pepo

et al. 2023

Food Chemistry Advances

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ANTIOXIDANT AND ANTIDIABETIC POTENTIALS OF Cucurbita pepo LEAVES EXTRACT FROM THE GULF REGION

Cited by 3 publications

References 0 publications

Pumpkin seeds and leaves as an alternative medicine for the treatment of hyperglycemia

Pumpkin seeds and leaves as an alternative medicine for the treatment of hyperglycemia

Assessment of In Vitro Antioxidant and Anti-Inflammatory Activities of Pumpkin (Cucurbita pepo) Natural Plant

Antimicrobial and antioxidant properties of the acetone extracts of the leaves of Lagenaria siceraria and Cucurbita pepo

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