Antioxidant and Antidiabetic activities of Alangium salvifolium and Bombax ceiba

Zahan, Ronok; Nahar, Laizuman; Haque, Mahmuda; Nesa, Mst. Luthfun; Alam, Md. Zahangir

doi:10.3329/dujps.v12i2.17617

Cited by 4 publications

(4 citation statements)

References 12 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extract was able to protect from the reduced longevity and to diminish whole body glucose levels induced by high glucose exposure. A similar effect has been observed in the alloxan-induced diabetic rats treated with B. ceiba bark methanolic extract [ 35 ]. Furthermore, the alcoholic extract of C. pentandra , a species taxonomically related to C. speciosa which is commonly used in North Africa, has been used to control hyperglycemia in diabetic patients [ 36 ].…”

Section: Discussionsupporting

confidence: 79%

Aqueous Bark Extract ofCeiba speciosa(A. St.-Hill) Ravenna Protects against Glucose Toxicity inCaenorhabditis elegans

Santos

Quines

Pilissão

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Plants are widely used in folk medicine because of their pharmacological properties. Ceiba speciosa, popularly known as paineira-rosa or tree-of-wool, is a species found in the Northwest of Rio Grande do Sul, being native of the upper Uruguay River, Brazil. The tea obtained from the stem bark is employed in folk medicine to reduce cholesterol, triacylglycerides, and glucose levels. However, there are no studies in the literature proving its efficacy or the safety of its use. For this study, we used Caenorhabditis elegans as an animal model considering its advantages for risk assessment and pharmacological screenings. For the toxicological tests, C. elegans N2 (wild type) was treated with the aqueous extract of the stem bark of C. speciosa (ECE) at the first larval stage (L1) at concentrations of 5, 25, 50, and 250 μg/mL. To evaluate biological activities, we challenged the extract for oxidative stress resistance in the presence of paraquat (0.5 mM), H2O2 (1 mM), and against glucose-induced toxicity. Our results demonstrated that ECE did not alter survival rate, pharyngeal pumping, and reproduction of the nematodes. The extract was not able to protect the nematodes against the toxicity induced by prooxidants. Notably, ECE protected against glucotoxicity by increasing worms’ life span and by reducing glucose levels. On the other hand, ECE treatment did not reduce lipid accumulation induced by exogenous glucose feeding, as observed in worms which lipid droplets were tagged with GFP. Based on our results, we believe that the extract is indeed promising for further studies focusing on carbohydrates metabolism; however, it needs to be carefully evaluated since the extract does not seem to modulate lipid accumulation.

show abstract

Section: Discussionsupporting

confidence: 79%

Aqueous Bark Extract ofCeiba speciosa(A. St.-Hill) Ravenna Protects against Glucose Toxicity inCaenorhabditis elegans

Santos

Quines

Pilissão

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…They used B. ceiba whole plant extract that showed higher scavenging activity against DPPH with IC 50 value of 68 μg / ml. In another study Zahan et al (2013) while studying the methanolic extract of bark of B. ceiba demonstrated good DPPH radical scavenging activity having IC 50 32.1 μg / ml. Antioxidant activity has been suggested to be associated to reducing power (Zengin et al 2010).…”

Section: Discussionmentioning

confidence: 92%

“…Jain et al (2011) described in their study that the methanolic extract of root demonstrated dose-dependent reduction from Fe³ + to Fe² + with highest absorbance of 1.11 at 500 µg / ml. In another work done by Zahan et al (2013) on methanolic extract of bark of B. ceiba showed that the extract possesses adequate reducing activity. Leafy and root vegetables contain large quantities of nitrite that is extremely toxic.…”

Section: Discussionmentioning

confidence: 95%

“…So, our findings are in accordance with these results with the difference that they studied leaf extract of the plant. Zahan et al (2013) reported that phenolic contents of 74.38±7.42 mg/g of garlic acid were detected in the methanolic extract of bark of B. ceiba. There are some studies that reported phenolic contents of the gum obtained from B. ceiba plant (Surveswaran et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial and Antioxidant Potential of Stem Bark Extract of Bombax Ceiba Collected Locally From South Punjab Area of Pakistan

Masood-Ur-Rehman

Akhtar

Mustafa

2017

Afr J Tradit Complement Altern Med

View full text Add to dashboard Cite

Background: Ethnic medication systems have been used extensively by humans since their origin. Now a day, in the developing countries these systems are being used due to their effectiveness and affordability. Especially inhabitants of rural areas still rely on these systems as first line of treatment against diseased conditions. Till now, majority of medicines is derived from the natural origin particularly plants owing to their little side effects and cost effectiveness. Materials and Methods:In the present work, we evaluated antibacterial and antioxidant activity of methanolic extract of Bombax ceiba stem bark. Total phenolic and flavonoid contents were also assessed in the extract. The antioxidant capacity was determined by DPPH, Nitric Oxide scavenging and reducing power activity. For antibacterial activity, Gram-negative (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi) and Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus) were used. Results: Phenolic content was 133.21±1.56 µg GAE/mg of extract while Flavonoid content was 997.93±2.14 µg QE/mg. Plant extract demonstrated strong antiradical activity with EC 50 18.78 ± 0.69 and 23.62 ± 1.99µg/ml for Nitric Oxide and DPPH assay respectively while EC 50 in case of reducing power activity was 139.4 ± 0.98µg/ml. Plant extract displayed inhibitory effect against microbial growth with S. typhi as the most resistant strain and Staphylococcus aureus the most sensitive one. Conclusion: This study revealed that Bombax ceiba of local origin has broad spectrum antibacterial activity and it can also provide defense against oxidative stress.

show abstract

Antibacterial, Antifungal and Antioxidant activity of leaf and fruit of Alangium salviifolium L. (Cornaceae)

Lavanya

Rao

Soundarya

et al. 2021

RJPT

View full text Add to dashboard Cite

Objectives: Alangium salviifolium L. is one of the medicinally important plant belonging to the family Cornaceae. The present study evaluates antibacterial, antifungal and antioxidant activity of leaf and fruit extracts of A. salviifolium. Methods: Extraction of shade dried and powdered leaf and fruit was carried out by maceration technique. Antibacterial and antifungal activity was evaluated by agar well diffusion method and poisoned food technique, respectively. Antioxidant activity was determined by antiradical (DPPH and ABTS assays) and ferric reducing assays. Results: Both leaf and fruit extracts displayed inhibitory activity against test bacteria. Fruit extract was shown to be more effective against test bacteria when compared to leaf extract. Leaf extract was more effective in causing inhibition of mycelial growth of test fungi when compared to fruit extract. Both leaf and fruit extracts scavenged DPPH and ABTS radicals dose dependently and exhibited ferric reducing activity. Conclusions: The results of the present study indicated the potential of leaf as well as fruit of A. salviifolium to exhibit antimicrobial and antioxidant activities which justifies the traditional medicinal uses of the plant.

show abstract

Antioxidant and Antidiabetic activities of Alangium salvifolium and Bombax ceiba

Cited by 4 publications

References 12 publications

Aqueous Bark Extract ofCeiba speciosa(A. St.-Hill) Ravenna Protects against Glucose Toxicity inCaenorhabditis elegans

Aqueous Bark Extract ofCeiba speciosa(A. St.-Hill) Ravenna Protects against Glucose Toxicity inCaenorhabditis elegans

Antibacterial and Antioxidant Potential of Stem Bark Extract of Bombax Ceiba Collected Locally From South Punjab Area of Pakistan

Antibacterial, Antifungal and Antioxidant activity of leaf and fruit of Alangium salviifolium L. (Cornaceae)

Contact Info

Product

Resources

About