Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum

Four New Diterpenoid Alkaloids from The Roots of Aconitum coreanum

“…[13] In addition, the spectroscopic data of one tertiary methyl group (δ(C) 29.8), six methylene groups (δ(C) 31.0, 31.7, 31.9, 36.8, 62.9, 109.5), eight methine groups (δ(C) 49.9, 53.8, 60.1, 63.3, 69.9, 70.0, 75.2, 81.4) and five quaternary carbons (δ(C) 37.6, 45.1, 46.3, 79.0, 143.7) further inferred that compound 1 was a hetisine-type C 20 -diterpenoid alkaloid. [8] By comparing the 13 C-NMR and MS features of 1 with those of known alkaloid Guan Fu base O (9), [14] their structures were very similar except for the propionyloxy group in 9 was substituted by the 2-methylbutanoyloxy group in 1.…”

“…The pharmacological studies showed that main active constituents were the diterpenoid alkaloids which had anti-arrhythmic, analgesic, anti-inflammatory effects and cholinesterase inhibition activities. [7,8] Guan Fu base A, the naturally occurring alkaloid primarily isolated from the roots of Aconitum coreanum, was developed into a novel drug extensively used for the therapeutic treatment of arrhythmia in clinical. [9] Apart from this typical one, Guan Fu base S was obtained to show inhibitory effect on blocking the ventricular specific sodium current, which was also expected to be developed as an anti-arrhythmia agent.…”

An overview of the chemical constituents from the genus Delphinium reported in the last four decades

“…The discovery of natural ChE inhibitors is an active research area in natural medicinal chemistry due to the involvement of cholinesterases in Alzheimer's disease and related dementias. 134 In the early 1990s, methyllycaconitine, one of the principal active constituents of Delphinium species, was found to be an effective ligand for neuronal nicotinic acetylcholine receptor (nAChR) subtypes, which attracted the attention of scientists to the screening of natural cholinesterase inhibitors from Delphinium species. Several Delphinium alkaloids have been reported to exhibit considerable ChE inhibitory effects ( Table 2).…”

In vivo screening of diterpene alkaloids using bdelloid rotifer assays

“…no. : 3657, Corning Inc., USA; n = 32) with diterpene alkaloids (1)(2)(3)(4)(5)(6)(7)(8). For this in vivo experiment stock solutions were prepared with 1% aqueous DMSO.…”

“…In case of songorine (10) it is assumed that the opioid system is involved [19]. Hetisinone (9) exerts anticholinesterase activity in vitro [1]. Several studies have reported central nervous system activities of these two compounds.…”