Antioxidant and anticancer activities from Stryphnodendron adstringens

Santos, Edson Lucas dos; Baldivia, Débora da Silva; Leite, Daniel Ferreira; Castro, David; Campos, Jaqueline Ferreira; Oliveira, Caio Fernando Ramalho de; Carvalho, José Tarcísio Giffoni de; Santos, Uilson Pereira dos; Souza, Kely de Picoli

doi:10.1016/j.freeradbiomed.2018.10.136

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, a study with an aqueous extract of S . adstringens with two times less TPC than our fraction (195.16 ± 0.94 mg GAE/g sample) showed that the extract increased the intracellular ROS levels, induced ΔΨm dysfunction and promoted apoptosis-induced cell death in B16F10Nex-2 melanoma cell [51], reinforcing our results.…”

Section: Resultssupporting

confidence: 85%

In vitro evaluation of the protective effects of plant extracts against amyloid-beta peptide-induced toxicity in human neuroblastoma SH-SY5Y cells

et al. 2019

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is the most common form of dementia and has no cure. Therapeutic strategies focusing on the reduction of oxidative stress, modulation of amyloid-beta (Aβ) toxicity and inhibition of tau protein hyperphosphorylation are warranted to avoid the development and progression of AD. The aim of this study was to screen the crude extracts (CEs) and ethyl-acetate fractions (EAFs) of Guazuma ulmifolia , Limonium brasiliense , Paullinia cupana , Poincianella pluviosa , Stryphnodendron adstringens and Trichilia catigua using preliminary in vitro bioassays (acetylcholinesterase inhibition, antioxidant activity and total polyphenol content) to select extracts/fractions and assess their protective effects against Aβ 25–35 toxicity in SH-SY5Y cells. The effect of the EAF of S . adstringens on mitochondrial membrane potential, lipid peroxidation, superoxide production and mRNA expression of 10 genes related to AD was also evaluated and the electropherogram fingerprints of EAFs were established by capillary electrophoresis. Chemometric tools were used to correlate the in vitro activities of the samples with their potential to be evaluated against AD and to divide extracts/fractions into four clusters. Pretreatment with the EAFs grouped in cluster 1 ( S . adstringens , P . pluviosa and L . brasiliense ) protected SH-SY5Y cells from Aβ 25-35 -induced toxicity. The EAF of S . adstringens at 15.62 μg/mL was able completely to inhibit the mitochondrial depolarization (69%), superoxide production (49%) and Aβ 25-35 -induced lipid peroxidation (35%). With respect to mRNA expression, the EAF of S . adstringens also prevented the MAPT mRNA overexpression (expression ratio of 2.387x) induced by Aβ 25–35 , which may be related to tau protein hyperphosphorylation. This is the first time that the neuroprotective effects of these fractions have been demonstrated and that the electropherogram fingerprints for the EAFs of G . ulmifolia , L . brasiliense , P . cupana , P . pluviosa and S . adstringens have been established. The study expands knowledge of the in vitro protective effects and quality control of the evaluated fractions.

show abstract

Section: Resultssupporting

confidence: 85%

In vitro evaluation of the protective effects of plant extracts against amyloid-beta peptide-induced toxicity in human neuroblastoma SH-SY5Y cells

et al. 2019

View full text Add to dashboard Cite

show abstract

“…

The bark of Stryphnodendron adstringens (Mart.) Coville is used in the traditional medicine because of its antidiabetic, antifungal, anti-inflammatory and healing properties (dos Santos et al, 2018). However, the removal of the bark, in an inappropriate way, may lead to tree death and, therefore, the use of leaves, that also have these properties, may turn this extractivist activity more sustainable (Sabino et al, 2018).

…”

mentioning

confidence: 99%

Oncideres saga Dalman: first record damaging Stryphnodendron adstringens Mart. Coville (Fabaceae) in Brazil

et al. 2022

View full text Add to dashboard Cite

Oncideres females girdle tree branches of the Fabaceae family, interrupting the sap flow and turning the wood conditions ideal for their larvae development. The bark of Stryphnodendron adstringens (Mart.) Coville, a species native to the Brazilian Cerrado, is widely used in the traditional medicine. The objectives were to report, for the first time, Oncideres saga (Dalman), using S. adstringens as a host and to describe the pattern of branch girdling and oviposition distribution by this insect on these branches. The diameter at the base and the length of the girdled branches were measured and the number of incisions made by the O. saga females to oviposit, per branch section (basal, median and apical), counted. The emerged specimens were counted and the diameter of the exit holes measured. The average diameter at the base of the girdled branches was 2.5 ± 0.16 cm and the length was 90.6 ± 4.6 cm. The average number of incisions per branch was 37.7 ± 2.7. Damage by O. saga can reduce the growth and cause losses on S. adstringens, a tree with great extractivism potential.,

show abstract

Silk Fibroin Hydrogels Incorporated with the Antioxidant Extract of Stryphnodendron adstringens Bark

et al. 2022

View full text Add to dashboard Cite

Barbatimão (Stryphnodendron adstringens) is a Brazilian medicinal plant known for its pharmacological properties, including healing activity related to its phenolic composition, which is chiefly given by tannins. In order to preserve its stability and bioactivity, barbatimão extracts can be incorporated into (bio-)polymeric matrixes, of which silk fibroin stands out due to its versatility and tunable properties. This work aimed to obtain barbatimão bark extract rich in phenolic compounds and evaluate its incorporation in fibroin hydrogels. From the extraction process, it was observed that the PG (propylene glycol) extract presented a higher global yield (X0) and phenolic compounds (TPC) than the ET (ethanol) extract. Furthermore, the antioxidant activity (ORAC and FRAP) was similar between both extracts. Regarding the hydrogels, morphological, chemical, thermal, and mechanical characterizations were performed to understand the influence of the barbatimão extract and the solvent on the fibroin hydrogel properties. As a result, the hydrogels containing the barbatimão PG extract (BT/PG hydrogels) showed the better physical–chemical and structural performance. Therefore, these hydrogels should be further investigated regarding their potential in medical and pharmaceutical applications, especially in wound healing.

show abstract

Antioxidant and anticancer activities from Stryphnodendron adstringens

Cited by 3 publications

References 0 publications

In vitro evaluation of the protective effects of plant extracts against amyloid-beta peptide-induced toxicity in human neuroblastoma SH-SY5Y cells

In vitro evaluation of the protective effects of plant extracts against amyloid-beta peptide-induced toxicity in human neuroblastoma SH-SY5Y cells

Oncideres saga Dalman: first record damaging Stryphnodendron adstringens Mart. Coville (Fabaceae) in Brazil

Silk Fibroin Hydrogels Incorporated with the Antioxidant Extract of Stryphnodendron adstringens Bark

Contact Info

Product

Resources

About