Antioxidant and antibacterial activities of Thymus numidicus and Salvia officinalis essential oils alone or in combination

Adrar, Nabil; Oukil, Naima; Bedjou, Fatiha

doi:10.1016/j.indcrop.2015.12.007

Cited by 75 publications

(41 citation statements)

References 37 publications

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“…All these methods were developed for the detection of drug interactions, for there is no standardized method known to evaluate interaction between total flavonoids and antibiotics. Dilution procedures were performed according to CLSI protocol M7A7-2006(Adrar, Oukil & Bedjou, 2016).…”

Section: Methodsmentioning

confidence: 99%

Antibacterial activity of total flavonoids from Ilex rotunda Thunb. and different antibacterials on different multidrug-resistant bacteria alone or in combination

Chai

Wang

et al. 2018

Preprint

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14The problem of bacterial resistance is becoming more and more serious, which 15 has become an urgent problem to be solved in human and veterinary. One approach to 16 control and delay bacterial resistance is combination therapy in which antibiotics are 17 given together with other antimicrobial or non-antimicrobial agents. Studies have 18 shown that flavonoids from Traditional Chinese medicine (TCM) possess a high level 19 of antibacterial activity against antibiotic resistant strains. The aim of this study was 20 to evaluate the antibacterial effects of a combined therapy of total flavonoids from 21 Ilex rotunda Thunb. and antibiotics against seven kinds of veterinary bacteria which 22 were multidrug resistance bacteria. A microdilution checkerboard method was used to 23 determine the minimal inhibitory concentrations of both types of antimicrobials, alone 24 and in combination. The fractional inhibitory concentration index was calculated and 25 used to classify observed collective antibacterial activity as synergistic, additive, 26 indifferent or antagonistic. 27 From the performed tests, the total flavonoids and antimicrobial agents were 28 combined to inhibit different multidrug-resistant bacteria, such as Escherichia coli, 29 Streptococcus, Pseudomonas aeruginosa, Enterococcus faecalis, Proteus vulgaris, 30 Staphylococcus aureus, Acinetobacter baumannii. For these bacteria, total flavonoids 31 from Ilex Rotunda Thunb. presented synergistic or additive with different antibiotics 32 and had a certain antibacterial effect on the separated multidrug-resistant bacteria. The 33 study shows total flavonoids from Ilex rotunda Thunb. have potential as adjuvants for 34 the treatment of animal bacterial diseases.35

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Section: Methodsmentioning

confidence: 99%

Antibacterial activity of total flavonoids from Ilex rotunda Thunb. and different antibacterials on different multidrug-resistant bacteria alone or in combination

Chai

Wang

et al. 2018

Preprint

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“…A broad variety of synthetic preservatives have been used to increase the shelf life of food and cosmetic products, but there is a growing trend to replace them by natural compounds, such as EOs or the compounds they contain . The fact that SoEOs act as bactericidal agents makes them possible natural alternative …”

Section: Introductionmentioning

confidence: 99%

Salvia officinalis L. Essential Oils from Spain: Determination of Composition, Antioxidant Capacity, Antienzymatic, and Antimicrobial Bioactivities

Cutillas

Carrasco

Martinez-Gutierrez³

et al. 2017

Chemistry & Biodiversity

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Four essential oils (EOs) from Salvia officinalis L. cultivated in Spain (Murcia Province) were analyzed by gas chromatography coupled with mass spectrometry (GC/MS) to determine their relative and absolute compositions. The main components were α-thujone (22.8 - 41.7%), camphor (10.7 - 19.8%), 1,8-cineole (4.7 - 15.6%), and β-thujone (6.1 - 15.6%). Enantioselective gas chromatography identified (-)-α-thujone and (+)-camphor as the main enantiomers in all the analyzed EOs. Furthermore, when the EOs were tested to determine their antioxidant activity against free radicals and as ferric reducing and ferrous chelating agents, all were seen to have moderate activity due to the compounds they contained, such as linalool or terpinene. Because of their known relation with inflammatory illnesses and Alzheimer's disease, respectively, the inhibition of lipoxygenase and acetylcholinesterase was studied using the EOs. Some individual compounds also inhibited these enzymes. In addition, the studied EOs were able to inhibit the growth of Escherichia coli, Staphylococcus aureus, and Candida albicans. The characterization carried out increases our awareness of the possible uses of S. officinalis EO as natural additives in food, cosmetics, and pharmaceuticals.

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“…Additional effect was noted with ciprofloxacine and Thymus numidicus essential oil combination tested against Staphylococcus aureus (S. aureus) [157]. Knezevic et al [158] obtained in vitro synergistic interactions of antibiotics ciprofloxacin, gentamicin and polymyxin B with Eucalyptus camaldulsensis essential oils against multidrug-resistant Acinetobacter baumannii isolates.…”

Section: Drug Combinations Activitymentioning

confidence: 99%

Recent advances in the identification and the study of composition and activities of medicinal plants

2016

J Coast Life Med

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Antioxidant and antibacterial activities of Thymus numidicus and Salvia officinalis essential oils alone or in combination

Cited by 75 publications

References 37 publications

Antibacterial activity of total flavonoids from Ilex rotunda Thunb. and different antibacterials on different multidrug-resistant bacteria alone or in combination

Antibacterial activity of total flavonoids from Ilex rotunda Thunb. and different antibacterials on different multidrug-resistant bacteria alone or in combination

Salvia officinalis L. Essential Oils from Spain: Determination of Composition, Antioxidant Capacity, Antienzymatic, and Antimicrobial Bioactivities

Recent advances in the identification and the study of composition and activities of medicinal plants

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