Antioxidant and antiapoptotic effects of pine needle powder ingestion and endurance training in high cholesterol-fed rats

Seo, Hye Young; Lee, Nam-Ho; Sungpil, Ryu

doi:10.5717/jenb.2014.18.3.301

Cited by 12 publications

(15 citation statements)

References 41 publications

(38 reference statements)

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“…Meanwhile, p53 protein is a well-known tumor suppressor. Bcl-2 protein expression is increased when the expression of p53 protein is suppressed 36 . Higgins et al 37 have reported that exercise can increase p53 protein expression in lung cancer tumor tissue and induce apoptosis in lung cancer.…”

Section: Discussionmentioning

confidence: 99%

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Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Seo

Park

Choi

et al. 2016

Journal of Exercise Nutrition &Amp; Biochemistry

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[Purpose]To determine whether voluntary exercise (wheel running) has the potential of relieving stress. [Methods]In this study, restraint stress with or without voluntary wheel running was performed for mice housed in individual cages. A total of 21 ICR male mice were assigned into control (CON), restraint stress with voluntary exercise (RSVE), or restraint stress (RS) without voluntary exercise groups (n = 7 each). [Results]No significant difference in body weight increase was found among the three groups, although CON and RS groups had a tendency of having smaller body weight increase compared to the RSVE group. No significant difference in the expression level of liver heat shock protein 70, Bcl-2, or p53 was found among the three groups. However, caspase-3 protein level in RS group was significantly higher than that in the other two groups. Blood cortisol concentration in RS was higher (p < 0.05) than that in RSVE or CON group. It was the lowest (p < 0.05) in the RSVE group. [Conclusion]Our findings suggest that apoptosis caused by chronic restraint stress might be suppressed by voluntary exercise in mice.

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Section: Discussionmentioning

confidence: 99%

“…Caspase-3 is a protein that directly induces apoptosis 36 . An eight-week swimming exercise training has resulted in significantly reduced apoptosis and apoptosis marker expression in the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Seo

Park

Choi

et al. 2016

Journal of Exercise Nutrition &Amp; Biochemistry

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“…7 ). In plants, ABA plays a central role in stomatal closure during drought stress [ 52 ]. The ABA signal in guard cells results in the production of nitric oxide and H 2 O 2 , leading to stomatal closure [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Physiological and Proteomic Adaptation of the Alpine Grass Stipa purpurea to a Drought Gradient

et al. 2015

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Stipa purpurea, an endemic forage species on the Tibetan Plateau, is highly resistant to cold and drought, but the mechanisms underlying its responses to drought stress remain elusive. An understanding of such mechanisms may be useful for developing cultivars that are adaptable to water deficit. In this study, we analyzed the physiological and proteomic responses of S. purpurea under increasing drought stress. Seedlings of S. purpurea were subjected to a drought gradient in a controlled experiment, and proteins showing changes in abundance under these conditions were identified by two-dimensional electrophoresis followed by mass spectrometry analysis. A western blotting analysis was conducted to confirm the increased abundance of a heat-shock protein, NCED2, and a dehydrin in S. purpurea seedlings under drought conditions. We detected carbonylated proteins to identify oxidation-sensitive proteins in S. purpurea seedlings, and found that ribulose-1, 5-bisphosphate carboxylase oxygenase (RuBisCO) was one of the oxidation-sensitive proteins under drought. Together, these results indicated drought stress might inhibit photosynthesis in S. purpurea by oxidizing RuBisCO, but the plants were able to maintain photosynthetic efficiency by a compensatory upregulation of unoxidized RuBisCO and other photosynthesis-related proteins. Further analyses confirmed that increased abundance of antioxidant enzymes could balance the redox status of the plants to mitigate drought-induced oxidative damage.

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“…In the view of this study, scientists revealed the importance of frequency of exercise [37]. Findings indicated that CR and EX play key role in normalization of endothelial function and improvement of GSH, SOD, MDA, 8-OHdG and apoptotic parameter levels [38]. We reported that CR and EX showed significant improvements in level of MDA and 8-OHdG levels in heart and aorta tissues.…”

Section: Biochemical Measurements In Heart and Aorta Tissuesmentioning

confidence: 74%

“…On the other hand, this level was recovered significantly in both tissues (dramatically in aorta; p<0.001) of all experimental groups by the administration of CR and EX (Figure 8). Furthermore, plenty of studies indicated that CR and EX have had regulatory effects on caspase-3 activity and dansity in aged animals [38,39]. Caspase-3 activity was found as reduced in animals with lifelong CR when compared with sedentary animals [40].…”

Section: Biochemical Measurements In Heart and Aorta Tissuesmentioning

confidence: 99%

Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascular hemodynamic and antioxidant system parameters

Macit¹,

Üstündağ²,

Eyupoglu³

et al. 2020

jrp

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Aging is a progressive and catabolic process by cells of the body are broken down. Study scrutinized the effects of exercise and caloric restriction in cardiovascular hemodynamics and antioxidant system parameters. Rats divided to 5 categories as 1 control group (including 3 months aged animals) and 4 test groups (including 15 months aged animals) named by A-SED (aged-sedentary), A-CR (aged-caloric restricted), A-EX (aged-exercised) and A-CR-EX (aged-(exercised + caloric restricted)) created by adding carbachol (CAR) and phenylephrine (PE) cumulatively and during 6 weeks, 40% caloric restriction and swimming were administered to aged animals. At the beginning and end of study, blood pressure (BP) and ECHO of the animals were measured. After decapitation process, tissue (heart and aorta) samples were collected. In tissue samples, apoptotic and oxidative stress parameters, and in blood samples NO levels were studied. Additionally, tissues were viewed as histologically at light microscopy. GraphPad Prism 5v. program was used for statistics and p<0.05 were considered significantly. Contraction-relaxation responses of aorta improved after CR and EX administrations (p<0.05). In both tissues, oxidative stress parameters (8-OHdG, MDA, SOD, GSH), caspase-3 activity and caspase-3 dansity were recovered meaningfully (p<0.05). Finally, NO levels were significantly recovered with CR and EX administrations in aged animals (p<0.05). To sum up, it is suggested that CR and EX administrations contribute to the recovery of hemodynamic and antioxidant system parameters in aged rats.

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Antioxidant and antiapoptotic effects of pine needle powder ingestion and endurance training in high cholesterol-fed rats

Cited by 12 publications

References 41 publications

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Physiological and Proteomic Adaptation of the Alpine Grass Stipa purpurea to a Drought Gradient

Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascular hemodynamic and antioxidant system parameters

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