Antioxidant and anti-inflammatory properties of Algerian Thymelaea microphylla coss. and dur. extracts

Dehimi, Khadidja; Speciale, Antonio; Saija, Antonella; Dahamna, Saliha; Raciti, Roberto; Cimino, Francesco; Cristani, Mariateresa

doi:10.4103/0973-1296.186345

Cited by 17 publications

(4 citation statements)

References 25 publications

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“…Similarly, the high percentage of bacterial strains tolerant to salinity, especially in the rhizosphere of T. microphylla (81% of the isolated strains tolerant to 28% of salt), is consistent with previous studies highlighting the role of halotolerant bacteria in arid and saline environments [18,[38][39][40]. However, to the best of our knowledge, no published paper deals with the bacterial community associated with this important plant with antioxidant and anti-inflammatory properties [41]; therefore, a comparison is impossible. Our findings support the idea that bacterial communities in arid and semi-arid zones possess unique adaptive traits to cope with challenging environmental conditions with an inestimable value, especially in the biotechnology field (enzymes, biomolecules, compatible solutes).…”

Section: Discussionsupporting

confidence: 86%

Rhizosphere Bacterial Isolation from Indigenous Plants in Arid and Semi-Arid Algerian Soils: Implications for Plant Growth Enhancement

Novello,

Bona,

Toumatia

et al. 2023

Processes

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The Mediterranean area is one of the geographic zones most affected by land degradation and desertification and these conditions appear to be even more exacerbated by climate change. Based on this idea, this work aimed to isolate, identify, characterize, and select bacterial strains able to tolerate salinity and drought, which could possibly be used in agriculture as plant biofertilizers. The sampling of rhizosphere soil was performed in two Algerian regions, Ghardaïa and Djelfa (arid and semi-arid zones, respectively) in six provinces, targeting fourteen native plant species, known for their therapeutic use. A total of 288 bacterial strains were isolated, identified, and characterized for their growth at different temperatures and salt tolerance. Based on these capabilities, 95 isolates were selected. These strains underwent further evaluation for their plant-beneficial traits, including siderophore synthesis, auxin production, and phosphate solubilization. Additionally, we assessed their impact on tomato, cucumber, and sorghum seed germination. In a final screening step, nine bacterial strains were tested for their potential plant growth-promoting activity on tomato plants grown in semi-controlled conditions. Our results demonstrated that three strains (Bacillus simplex AH24, Microbacterium arborescens PU10, and Microbacterium paludicola AEA23) showed plant growth promotion activities on tomato.

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Section: Discussionsupporting

confidence: 86%

Rhizosphere Bacterial Isolation from Indigenous Plants in Arid and Semi-Arid Algerian Soils: Implications for Plant Growth Enhancement

Novello,

Bona,

Toumatia

et al. 2023

Processes

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“…While ORAC and Folin–Ciocalteu tests are not suitable for measuring liposoluble antioxidants, ABTS can measure the activity of both water-soluble antioxidants and liposoluble ones and DPPH in turn is soluble only in organic solvents [27, 28]. …”

Section: Resultsmentioning

confidence: 99%

Bioactivity and Toxicity of Senna cana and Senna pendula Extracts

Monteiro

Júnior

Oliveira

et al. 2018

Biochemistry Research International

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This work investigated the content of total polyphenolic compounds and flavonoids as well as their toxicity and larvicidal and acetylcholinesterase inhibitory activities. The antioxidant activities of two medicinal Senna species extracts (Senna cana and Senna pendula) were also investigated. The ethanol extract of the leaves of S. cana and the ethanol extract of the branches of S. pendula presented the best performance in the DPPH/FRAP and ABTS/ORAC assays, respectively. For the inhibition of acetylcholinesterase, the hexane extract of the flowers of S. pendula presented the lowest IC50 value among the ethanol extracts of the leaves of S. cana and showed the best performance in some assays. The hexane extract of the leaves of S. pendula and the hexane extract of the branches of S. cana were moderate to Artemia salina Leach. In the quantification of phenols and flavonoids, the ethanol extract of the leaves of S. cana presented the best results. The ethanol extracts of the leaves of S. cana were found to be rich in antioxidants, phenolic compounds, and flavonoids. These results indicate the antioxidant potential of the extracts of Senna species and can be responsible for some of the therapeutic uses of these plants.

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“…Leukocyte adhesion assay was performed as described elsewhere [ 14 ]. Briefly, after the treatments above described, transwell inserts containing Caco-2 monolayers were removed and HUVECs were washed with DPBS and then cocultured with human leukocytes (3 × 10 6 leukocytes/flask) for 2 h at 37°C with gentle shaking.…”

Section: Methodsmentioning

confidence: 99%

“…HUVECs-leukocytes cocultures were visualized under an inverted microscope and photographed using a digital camera. Increase in leukocytes adhesion was calculated in relation to the basal adhesion of leukocytes to control cells that was set to 1 [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

Cyanidin-3-O-Glucoside Modulates the In Vitro Inflammatory Crosstalk between Intestinal Epithelial and Endothelial Cells

Ferrari

Cimino

Fratantonio

et al. 2017

Mediators of Inflammation

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Intestinal epithelium represents a protective physical barrier and actively contributes to the mucosal immune system. Polarized basolateral intestinal secretion of inflammatory mediators, followed by activation of NF-κB signaling and inflammatory pathways in endothelial cells, efficiently triggers extravasation of neutrophils from the vasculature, therefore contributing to the development and maintenance of intestinal inflammation. Proper regulation of NF-κB activation at the epithelial interface is crucial for the maintenance of physiological tissue homeostasis. Many papers reported that anthocyanins, a group of compounds belonging to flavonoids, possess anti-inflammatory effects and modulate NF-κB activity. In this study, by using a coculture in vitro system, we aimed to evaluate the effects of TNF-α-stimulated intestinal cells on endothelial cells activation, as well as the protective effects of cyanidin-3-glucoside (C3G). In this model, TNF-α induced nuclear translocation of NF-κB and TNF-α and IL-8 gene expression in Caco-2 cells, whereas C3G pretreatment dose-dependently reduced these effects. Furthermore, TNF-α-stimulated Caco-2 cells induced endothelial cells activation with increased E-selectin and VCAM-1 mRNA, leukocyte adhesion, and NF-κB levels in HUVECs, which were inhibited by C3G. We demonstrated that selective inhibition of the NF-κB pathway in epithelial cells represents the main mechanism by which C3G exerts these protective effects. Thus, anthocyanins could contribute to the management of chronic gut inflammatory diseases.

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Antioxidant and anti-inflammatory properties of Algerian Thymelaea microphylla coss. and dur. extracts

Cited by 17 publications

References 25 publications

Rhizosphere Bacterial Isolation from Indigenous Plants in Arid and Semi-Arid Algerian Soils: Implications for Plant Growth Enhancement

Rhizosphere Bacterial Isolation from Indigenous Plants in Arid and Semi-Arid Algerian Soils: Implications for Plant Growth Enhancement

Bioactivity and Toxicity of Senna cana and Senna pendula Extracts

Cyanidin-3-O-Glucoside Modulates the In Vitro Inflammatory Crosstalk between Intestinal Epithelial and Endothelial Cells

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