Antioxidant and anti-inflammatory properties of marmelosin from Bael (Aegle marmelos L.); Inhibition of TNF-α mediated inflammatory/tumor markers

Pynam, Hasitha; Dharmesh, Shylaja M.

doi:10.1016/j.biopha.2018.06.053

Cited by 54 publications

(52 citation statements)

References 34 publications

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“…The apoptotic pathway has also been reported to be activated by the marmelin through the activation of cascade series of caspase-8, caspase-3 and truncated Bid. The apoptotic efficiency of marmelosin has also been reported by Pynam and Dharmesh 51 . The β-caryophyllene and Caryophyllene oxide obtained from fruit extracts of Aegle marmelos coaxed apoptosis in Jurkat cell lines 52 .…”

Section: Discussionsupporting

confidence: 62%

“…The phytochemicals marmelin and marmelosin present in the Aegle marmelos fruit pulp may be responsible for the observed pharmacological properties of the plant extract. These phytochemicals functions through the suppression of NF-k B activation and subsequent reduction in the p-AKT levels and thus decreases the cell survival, proliferation, and invasiveness [49][50][51] . The apoptotic pathway has also been reported to be activated by the marmelin through the activation of cascade series of caspase-8, caspase-3 and truncated Bid.…”

Section: Discussionmentioning

confidence: 99%

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Therapeutic effect of Aegle marmelos fruit extract against DMBA induced breast cancer in rats

Akhouri

Kumari

Kumar

2020

Sci Rep

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Breast cancer is among most common form of cancer worldwide. It is also the major cause of death in female cancer patient around the world. Despite various therapeutic measures, it remains associated with high mortality rate. Aegle marmelos (L.) Correa has been extensively used in Indian medicine system Ayurveda, due to its various medicinal properties. However, there are very limited reports regarding its anticancer activity. Thus, the present research work has been aimed to study the anticancer activity of Aegle marmelos fruit extract on 7,12-dimethylbenz(a)anthracene (DMBA) induced breast cancer in rats. Female Charles Foster rats, 55–60 days old weighing around (150 ± 10 g) were used for the study and were induced DMBA (20 mg/mL dissolved in Olive oil) orally. After the development of breast tumors (about 0.5 cm), the rats were treated with Aegle marmelos ethanolic fruit pulp extract (200 mg/kg b.w./day) orally for 5 weeks and then volume of tumor was measured. Aegle marmelos treatment showed significantly reduced mammary tumor volume (P < 0.05), along with significant reduction (P < 0.0001) in the different serum biomarkers such as TNF-α level, serum malondialdehyde (MDA) level and glucose levels. Significant (P < 0.0001) improvement in both, the kidney and liver serum biomarker parameters were also observed after the treatment with Aegle marmelos ethanolic fruit pulp extract. From the entire study, taking everything into account it can be interpreted that Aegle marmelos ethanolic fruit pulp extract possesses anti-proliferative activity by suppressing the progression of breast tumors in rat model. The plant extract also possesses hepato-renal protective effect. Hence, it can be targeted as novel and safe anti-cancer drug against breast cancer.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of Aegle marmelos fruit extract against DMBA induced breast cancer in rats

Akhouri

Kumari

Kumar

2020

Sci Rep

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“…In general, polar solvents, such as water (H 2 O), methanol (MeOH), ethanol (EtOH), acetone, and their aqueous mixtures, are the most widely used as extraction solvents [47,49,50,51,52,53,54,55,57,58,60,61,62,63,64,65,66,67,68,69,70,71,72,73]. The use of EtOAc, chloroform, dichloromethane, and petroleum ether has also been described in the literature [56,59,61,67,74,75,76,77,78]. Kvievis et al have recently evaluated the content of furanocoumarins in the seeds of P. sativa [79].…”

Section: Extraction Of Furanocoumarins From Plantsmentioning

confidence: 99%

“…If the final purpose is the isolation of furocoumarins from the plant material for the evaluation of their biological activity, the raw extract obtained has been usually submitted to further purification steps [52,65,66,69,70,71,72,74,91]. In this case, Soxhlet extraction and heat reflux extraction (HRE) have been widely applied with both polar and non-polar solvents [71,72,74,75,77]. After the extraction, furanocoumarins have been frequently isolated from the raw extracts by means of sequential silica gel column chromatography, eluted under normal phase conditions [66,69,70,71,72,75,76,77,78,79].…”

Section: Extraction Of Furanocoumarins From Plantsmentioning

confidence: 99%

Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest

et al. 2019

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The aim of this work is to provide a critical review of plant furanocoumarins from different points of view, including their chemistry and biosynthetic pathways to their extraction, analysis, and synthesis, to the main biological activities found for these active compounds, in order to highlight their potential within pharmaceutical science. The limits and the possible improvements needed for research involving these molecules are also highlighted and discussed.

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“…They provide antimicrobial and insecticidal activity and behave as natural pesticides [ 10 ]. Furocoumarins have promising therapeutic prospects, such as analgesic, anticonvulsive, anticoagulant, hypotensive, antidepressants, antibacterial, antifungal, antiviral, anti-inflammatory, antiallergic [ 11 , 12 ], antioxidants [ 13 ], and inhibitors of human carbonic anhydrase isozymes [ 14 ], against skin diseases [ 15 , 16 ], hyperproliferative disorders [ 17 , 18 ] and as an anticancer [ 19 ]. This review is aimed at evaluating the literature on the anticancer potential of various furanocoumarins through different underlying mechanisms and thereof therapeutic/clinical status.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Ahmed

Khan

Aschner

et al. 2020

IJMS

128

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Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication. Furanocoumarins’ defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signaling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemo preventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as a cancer lessening agents.

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Antioxidant and anti-inflammatory properties of marmelosin from Bael (Aegle marmelos L.); Inhibition of TNF-α mediated inflammatory/tumor markers

Cited by 54 publications

References 34 publications

Therapeutic effect of Aegle marmelos fruit extract against DMBA induced breast cancer in rats

Therapeutic effect of Aegle marmelos fruit extract against DMBA induced breast cancer in rats

Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

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