Antioxidant and Anti-Inflammatory Effects of Scoparia dulcis L.

Abstract

Different extracts were obtained from Scoparia dulcis L. (Scrophulariaceae) by successive extraction with hexane, chloroform, and methanol. These extracts exhibited significant antioxidant capacity in various antioxidant models mediated (xantine oxidase and lipoxygenase) or not mediated (2,2-diphenyl-picrylhydrazyl, ferric-reducing antioxidant power, β-carotene bleaching, lipid peroxidation) by enzymes. The antioxidant activity of the extracts was related to their phytochemical composition in terms of polyphenol and carotenoid contents. The chloroform extract was richest in phytochemicals and had the highest antioxidant activity in the different antioxidant systems. All the extracts exhibited less than 50% inhibition on xanthine oxidase but more than 50% inhibition on lipid peroxidation and lipoxygenase. The extracts strongly inhibited lipid peroxidation mediated by lipoxygenase.

Anti-proliferative effect of <i>Scoparia dulcis</i> L. against bacterial and fungal strains

“…This is in accordance with previous studies which pointed non polar extracts to be particularly active on Aspergillus sp, Penicillium sp and Fusarium sp (Mahlo et al, 2010). The strong activity of these non-polar extracts could be related to their high content in terpenes such as β-carotene and lycopene (Coulibaly et al, 2011b) as previously suggested (Gudzic et al, 2002;Cakir et al, 2004).…”

“…Some investigations previously evidenced its use to help with the symptoms of several diseases such as arterial hypertension and diabetes mellitus (Satyanarayana, 1969). A number of the medicinal properties of S. dulcis have been previously demonstrated including its anti-diabetic, anti-inflammatory and antioxidant activities in vivo (Pari and Latha, 2005;Adaikpoh et al, 2007), its potent inhibition of DPPH radicals (Babincová and Sourivong, 2001), its antimicrobial activity (Latha et al, 2006) and its impact on lipid peroxidation (Ratnasooriya et al, 2005;Coulibaly et al, 2011b). Furthermore a few phenolic and terpenic compounds have been isolated from S. dulcis including scoparic acid A, scoparic acid B, scopadulin (Hayashi et al, 1991), scopadulcic acid A and B, scopadulciol, scopadulin (Hayashi et al, 1990) and were identified as contributing to the observed medicinal effect of the plant.…”

Antidiabetic Properties, Bioactive Constituents, and Other Therapeutic Effects of Scoparia dulcis

“…Babincová and Sourivong used the DPPH assay to demonstrate strong antioxidant activity of the extract [59]. Coulibaly et al [60] studied the antioxidant property of the hexane, chloroform, and methanol extracts of the plant by the DPPH and FRAP assays. In addition, inhibition of lipid peroxidation was measured by the TBARS assay and inhibition of lipoxygenase and xanthine oxidase by the extracts was determined [60].…”

“…Coulibaly et al [60] studied the antioxidant property of the hexane, chloroform, and methanol extracts of the plant by the DPPH and FRAP assays. In addition, inhibition of lipid peroxidation was measured by the TBARS assay and inhibition of lipoxygenase and xanthine oxidase by the extracts was determined [60]. They found that the chloroform extract exhibited the highest activity and concluded that the phytochemical content being the highest in this extract was the responsible factor for the observation [61, 62].…”

Inhibition of LDL oxidation and oxidized LDL-induced foam cell formation in RAW 264.7 cells show anti-atherogenic properties of a foliar methanol extract of Scoparia dulcis

“…These include anti-diabetic properties, anti-hypertensive effects as well as anti-hyperlipidemic and anti-tumour effects. [67] Recently, Coulibaly et al .,[8] showed that the whole S. dulcis plant possessed high antioxidant and anti-inflammatory properties. Furthermore, it has been reported to lower the LDL cholesterol levels in streptozotocin-diabetic rats.…”