Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study

Peris-Martínez, Cristina; Piá-Ludeña, José Vicente; Rog-Revert, María José; Fernández-López, Ester; Domingo, Joan Carles

doi:10.3390/nu15051300

Cited by 11 publications

(4 citation statements)

References 45 publications

(55 reference statements)

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“… Medications that reduce the often-coexisting allergic and ocular symptoms in KC patients. 13 , 52 , 53 …”

Section: Resultsmentioning

confidence: 99%

Keratoconus: exploring fundamentals and future perspectives – a comprehensive systematic review

Niazi,

Gatzioufas,

Doroodgar

et al. 2024

Ophthalmol Eye Dis

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Background: New developments in artificial intelligence, particularly with promising results in early detection and management of keratoconus, have favorably altered the natural history of the disease over the last few decades. Features of artificial intelligence in different machine such as anterior segment optical coherence tomography, and femtosecond laser technique have improved safety, precision, effectiveness, and predictability of treatment modalities of keratoconus (from contact lenses to keratoplasty techniques). These options ingrained in artificial intelligence are already underway and allow ophthalmologist to approach disease in the most non-invasive way. Objectives: This study comprehensively describes all of the treatment modalities of keratoconus considering machine learning strategies. Design: A multidimensional comprehensive systematic narrative review. Data sources and methods: A comprehensive search was done in the five main electronic databases (PubMed, Scopus, Web of Science, Embase, and Cochrane), without language and time or type of study restrictions. Afterward, eligible articles were selected by screening the titles and abstracts based on main mesh keywords. For potentially eligible articles, the full text was also reviewed. Results: Artificial intelligence demonstrates promise in keratoconus diagnosis and clinical management, spanning early detection (especially in subclinical cases), preoperative screening, postoperative ectasia prediction after keratorefractive surgery, and guiding surgical decisions. The majority of studies employed a solitary machine learning algorithm, whereas minor studies assessed multiple algorithms that evaluated the association of various keratoconus staging and management strategies. Last but not least, AI has proven effective in guiding the implantation of intracorneal ring segments in keratoconus corneas and predicting surgical outcomes. Conclusion: The efficient and widespread clinical translation of machine learning models in keratoconus management is a crucial goal of potential future approaches to better visual performance in keratoconus patients. Trial registration: The article has been registered through PROSPERO, an international database of prospectively registered systematic reviews, with the ID: CRD42022319338

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“… Medications that reduce the often-coexisting allergic and ocular symptoms in KC patients. 13 , 52 , 53 …”

Section: Resultsmentioning

confidence: 99%

Keratoconus: exploring fundamentals and future perspectives – a comprehensive systematic review

Niazi,

Gatzioufas,

Doroodgar

et al. 2024

Ophthalmol Eye Dis

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“…In a recent study, patients with keratoconus received DHA (1000 mg) supplementation for three months, resulting in higher total antioxidant capacity and better outcomes in the astigmatism axis, asphericity coefficient, and intraocular pressure than the placebo group [ 165 ].…”

Section: Defense Of Cellular Membranes With Lipophilic Antioxidantsmentioning

confidence: 99%

Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases

Rodella

Honisch

Gatto³

et al. 2023

Nutrients

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This review aims to discuss the delicate balance between the physiological production of reactive oxygen species and the role of antioxidant nutraceutical molecules in managing radicals in the complex anatomical structure of the eye. Many molecules and enzymes with reducing and antioxidant potential are present in different parts of the eye. Some of these, such as glutathione, N-acetylcysteine, α-lipoic acid, coenzyme Q10, and enzymatic antioxidants, are endogenously produced by the body. Others, such as plant-derived polyphenols and carotenoids, vitamins B2, C, and E, zinc and selenium, and omega-3 polyunsaturated fatty acids, must be obtained through the diet and are considered essential nutrients. When the equilibrium between the production of reactive oxygen species and their scavenging is disrupted, radical generation overwhelms the endogenous antioxidant arsenal, leading to oxidative stress-related eye disorders and aging. Therefore, the roles of antioxidants contained in dietary supplements in preventing oxidative stress-based ocular dysfunctions are also discussed. However, the results of studies investigating the efficacy of antioxidant supplementation have been mixed or inconclusive, indicating a need for future research to highlight the potential of antioxidant molecules and to develop new preventive nutritional strategies.

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“…DHA functions as a potent antioxidant and plays a crucial role in neural tissues such as the brain and retina [ 18 ]. Multiple clinical studies have demonstrated that oral supplementation of DHA can significantly improve the oxidative stress state in the blood [ 19 ], alleviate age-related ocular diseases [ 20 ], and provide various benefits, including neuroprotection [ 21 ]. Additionally, its potential role in cancer therapy is increasingly gaining attention.…”

Section: Introductionmentioning

confidence: 99%

Docosahexaenoic Acid Coordinating with Sodium Selenite Promotes Paraptosis in Colorectal Cancer Cells by Disrupting the Redox Homeostasis and Activating the MAPK Pathway

Zhao,

Meng,

Cai

et al. 2024

Nutrients

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Tumor cells are characterized by a delicate balance between elevated oxidative stress and enhanced antioxidant capacity. This intricate equilibrium, maintained within a threshold known as redox homeostasis, offers a unique perspective for cancer treatment by modulating reactive oxygen species (ROS) levels beyond cellular tolerability, thereby disrupting this balance. However, currently used chemotherapy drugs require larger doses to increase ROS levels beyond the redox homeostasis threshold, which may cause serious side effects. How to disrupt redox homeostasis in cancer cells more effectively remains a challenge. In this study, we found that sodium selenite and docosahexaenoic acid (DHA), a polyunsaturated fatty acid extracted from marine fish, synergistically induced cytotoxic effects in colorectal cancer (CRC) cells. Physiological doses of DHA simultaneously upregulated oxidation and antioxidant levels within the threshold range without affecting cell viability. However, it rendered the cells more susceptible to reaching the upper limit of the threshold of redox homeostasis, facilitating the elevation of ROS levels beyond the threshold by combining with low doses of sodium selenite, thereby disrupting redox homeostasis and inducing MAPK-mediated paraptosis. This study highlights the synergistic anticancer effects of sodium selenite and DHA, which induce paraptosis by disrupting redox homeostasis in tumor cells. These findings offer a novel strategy for more targeted and less toxic cancer therapies for colorectal cancer treatment.

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Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study

Cited by 11 publications

References 45 publications

Keratoconus: exploring fundamentals and future perspectives – a comprehensive systematic review

Keratoconus: exploring fundamentals and future perspectives – a comprehensive systematic review

Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases

Docosahexaenoic Acid Coordinating with Sodium Selenite Promotes Paraptosis in Colorectal Cancer Cells by Disrupting the Redox Homeostasis and Activating the MAPK Pathway

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