Antioxidant and anti-inflammatory effects of a methanol extract from the marine sponge Hyrtios erectus

Muthiyan, Ramachandran; Mahanta, Nilkamal; Nambikkairaj, Balwin; Immanuel, Titus; De, Arun Kumar

doi:10.4103/pm.pm_133_17

Cited by 6 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As discussed by Williams et al [67], the major advantages of abovementioned assays is the removal of additional animal experiments, particularly when working with crude extracts or low amounts of samples to conduct the studies. Both assays are rarely employed in the studies of marine-derived extracts or compounds, but tested on marine sponge sample of Hyrtios erectus [68].…”

Section: In Vitro Anti-inflammatory Activitiesmentioning

confidence: 99%

Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini

et al. 2021

View full text Add to dashboard Cite

Due to sedentary lifestyle and harsh environmental conditions, gorgonian coral extracts are recognized as a rich source of novel compounds with various biological activities, of interest to the pharmaceutical and cosmetic industries. The presented study aimed to perform chemical screening of organic extracts and semi-purified fractions obtained from the common Adriatic gorgonian, sea fan, Eunicella cavolini (Koch, 1887) and explore its abilities to exert different biological effects in vitro. Qualitative chemical evaluation revealed the presence of several classes of secondary metabolites extended with mass spectrometry analysis and tentative dereplication by using Global Natural Product Social Molecular Networking online platform (GNPS). Furthermore, fractions F4 and F3 showed the highest phenolic (3.28 ± 0.04 mg GAE/g sample) and carotene (23.11 ± 2.48 mg β-CA/g sample) content, respectively. The fraction F3 inhibited 50% of DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) and ABTS (2,2′-azino-bis (3-ethylbenzthiazolin-6-yl) sulfonic acid) radicals at the concentrations of 767.09 ± 11.57 and 157.16 ± 10.83 µg/mL, respectively. The highest anti-inflammatory potential was exhibited by F2 (IC50 = 198.70 ± 28.77 µg/mL) regarding the inhibition of albumin denaturation and F1 (IC50 = 254.49 ± 49.17 µg/mL) in terms of soybean lipoxygenase inhibition. In addition, the most pronounced antiproliferative effects were observed for all samples (IC50 ranging from 0.82 ± 0.14–231.18 ± 46.13 µg/mL) against several carcinoma cell lines, but also towards non-transformed human fibroblasts pointing to a generally cytotoxic effect. In addition, the antibacterial activity was tested by broth microdilution assay against three human pathogenic bacteria: Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The latter was the most affected by fractions F2 and F3. Finally, further purification, isolation and characterization of pure compounds from the most active fractions are under investigation.

show abstract

Section: In Vitro Anti-inflammatory Activitiesmentioning

confidence: 99%

Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The marine organisms offer abundant sources of novel bioactive compounds that lead to new drug discoveries (Hu et al, 2015). The vast biological diversity of the marine ecosystem, such as coral reefs and marine sponges is extremely varied as compared to the tropical rainforest (Costello & Chaudhary, 2017;De et al, 2018). Porifera is a group of multicellular primitive metazoans being reported as the source of numerous bioactive secondary metabolites by past research (Bhatnagar et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Biological Activity of Three Marine Sponges From Theonella and Haliclona Genera Collected From Bidong Island, Terengganu, Malaysia

Jamaludin,

Bakar,

Saidin

2023

MAB

View full text Add to dashboard Cite

Marine sponges are primitive sessile animals that are rich sources of biologically active compounds. This paper aimed to assess the in-vitro biological activity of marine sponges from Theonella and Haliclona genera collected from Bidong Island, Terengganu, Malaysia. Biological activities such as antibacterial (discs diffusion assay), antioxidant (DPPH free-radical scavenging assay), and cytotoxicity activity (against cancerous HeLa, MCF-7, HepG-2 cell lines and the normal cell line Vero) were evaluated using MTT cytotoxicity assay. The bioassays were done on methanol extracts at different concentrations. Results indicate that T. swinhoei, and T. cf cupola showed low antibacterial capabilities ranging from 0 to 50 mg/mL and exhibited medium antioxidant activity with the IC50 value of 23.25 ± 1.57 and 18.52 ± 0.86 mg/mL, respectively. Cytotoxicity activities indicate that both species of T. swinhoei and T. cf cupola possesses toxic capabilities to inhibit the proliferation of all cancer cell lines used and demonstrated no significant toxicity for the normal cell line used in this study. Haliclona fascigera showed medium antibacterial activity against all Gram-positive bacteria and low activity against Gram-negative bacteria used. Haliclona fascigera exhibited antioxidant activity with an IC50 value of 1.80 ± 0.08 mg/mL and outcomes of the cytotoxicity activity assay against all cancer cells showed IC50 below 30 µg/mL. Marine sponges evaluated in this study indicate promising bioactive compounds that can be an excellent candidate for drug discovery in prospecting novel antibiotics and anticancer. Despite showing low antibacterial and medium antioxidant activity, species from both Theonella can be further studied in other assays to explore other biological activities whilst marine sponge H. fascigera possesses excellent capabilities in antibacterial, antioxidant, and cytotoxicity activities that can be further studied its chemical compositions for future research.

show abstract

Biodiversity of endosymbiont fungi associated with a marine sponge Lamellodysidea herbacea and their potential as antioxidant producers

Katoch,

Singh,

Bijarnia

et al. 2024

3 Biotech

View full text Add to dashboard Cite

Antioxidant and anti-inflammatory effects of a methanol extract from the marine sponge Hyrtios erectus

Cited by 6 publications

References 2 publications

Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini

Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini

In Vitro Biological Activity of Three Marine Sponges From Theonella and Haliclona Genera Collected From Bidong Island, Terengganu, Malaysia

Biodiversity of endosymbiont fungi associated with a marine sponge Lamellodysidea herbacea and their potential as antioxidant producers

Contact Info

Product

Resources

About