Antioxidant and anti-inflammatory activity of Polygonatum sibiricum rhizome extracts

Debnath, Trishna; Park, Sa Ra; Kim, Da Hey; Jo, Jeong Eun; Lim, Beong Ou

doi:10.1016/s2222-1808(13)60074-2

Cited by 40 publications

(17 citation statements)

References 24 publications

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“…Several bioactive compounds from plants (Wang et al, 2013c), rhizomes (Debnath et al, 2013) and marine algae (Kim et al, 2014) have been isolated and their anti-inflammatory effect studied by various mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

108

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Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach:The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action.Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions:The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites.Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

108

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“…This assay was conducted via electron spin resonance (ESR) technique (JES-FA100, JEOL Ltd., Tokyo, Japan) as described in a previous study [27]. Firstly, 10 mM H 2 O 2 and 0.3 M DMPO were diluted using PBS buffer (pH 7.4).…”

Section: Hydroxyl Radical Scavenging Activitymentioning

confidence: 99%

“…Griess reagent method was used for the evaluation of nitric oxide (NO) production in RAW 264.7 cells [27]. Cells were seeded (5 × 10 4 cells/well) with DMEM medium in 96 well-plates.…”

Section: Measurement Of Nitric Oxidementioning

confidence: 99%

Evaluation of the Antioxidant and Anti-Inflammatory Potential of Fermented Achyranthes japonica Nakai Extract

Mijan¹,

Park²,

Lee³

et al. 2018

Nat Prod Chem Res

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Achyranthes japonica Nakai (AJ) is a medicinal plant and has well-known health benefits. This study has evaluated the antioxidant and anti-inflammatory activities of the fermented extract of AJ (FAJ). Fermentation of the extract increased the total phenolic and flavonoid contents of AJ. FAJ showed significantly higher free radical scavenging activities as compared with NFAJ. In addition, FAJ exhibited higher ferric (Fe 3+ ) reducing activity than NFAJ. FAJ inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)induced RAW 264.7 cells at a higher level than NFAJ without affecting the cell viability. The mRNA expression of tumor necrosis factor α (TNF-α) in RAW 264.7 cells was substantially reduced by FAJ treatment. Moreover, the upregulation of pp38 and protein kinase RNA-like endoplasmic reticulum kinase (pERK) by LPS in RAW 264.7 cells was markedly suppressed by FAJ. These results suggest that FAJ has therapeutic potential as an antioxidant and anti-inflammatory agent.

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“…The earliest recording of the use of Polygonatum plants is in The Chinese pharmacopoeia, and the polygonatum sibiricum is considered to be the "Top grade" herbs in Shennong Bencao Jing (100 BCE-200 CE, Qin and Han Dynasties) due to their life span-prolonging effect and nontoxicity [2][3],which is a kind of commonly used Chinese herbal medicines for the 2015 edition of the Chinese Pharmacopoeia [4]. Polygonatum sibiricum have a variety of pharmacological properties such as anti-diabetic [5], anti-inflammatory [6], anti-atherosclerosis [7] and bone protective effects [8]. Polygonatum plants are also a kind of medicinal and edible homologous plant which are widely used by the people in the folk, and the Polygonatum cyrtonema Hua which in the Jiuhua Mountain area of Anhui Province.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Low-Sugar Polygonatum Jam Production Process by Response Surface Methodology

Feng¹,

Zhang²,

Wu³

et al. 2019

AFSE

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Polygonatum jam was used as the main raw material in this experiment, on the basis of the single-factor experiment, the interaction of xylitol, citric acid, CaCl2, low-methoxy pectin was investigated according to Box-Benhnken design. The sensory score and textural properties were used as the indicators to determine the optimum parameters of the low-sugar polygonatum jam. The results showed that the ideal parameters to product low-sugar polygonatum jam were as follows: xylitol 9.28%, citric acid 0.05%, CaCl2 0.51%, and low-methoxy pectin 1.02%. The sensory index of verification experiment was 95.7 which was basically consistent with the theoretical value 95.1.

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Antioxidant and anti-inflammatory activity of Polygonatum sibiricum rhizome extracts

Cited by 40 publications

References 24 publications

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Evaluation of the Antioxidant and Anti-Inflammatory Potential of Fermented Achyranthes japonica Nakai Extract

Optimization of Low-Sugar Polygonatum Jam Production Process by Response Surface Methodology

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