ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF &lt;i&gt;ACALYPHA FRUTICOSA&lt;/i&gt;

Gupta, Manoj Kumar; Mazumdar, UK; Sivahkumar, T; Vamis, Mlm; Karki, Subhas S.; Sambathkumar, R; Manikandan, L. C.

doi:10.4314/njnpm.v7i1.11700

Cited by 33 publications

(33 citation statements)

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“…Antioxidant activity by DPPH scavenging assay of R. damascena Antioxidant activity of the ethanolic extract was determined on the basis of their scavenging activity of the stable DPPH free radical. Quantitative assay was performed on the basis of the modified method of Gupta et al (2003). Stock solutions (10 mg/ml) of the plant extracts were prepared in ethanol from which serial dilutions were carried out to obtain concentrations of 1, 5, 10, 50, 100 and 500 mg/ml.…”

Section: Preparation Of Ethanol Extractsmentioning

confidence: 99%

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Antioxidant and hepatoprotective action of the crude ethanolic extract of the flowering top of Rosa damascena

Alam¹,

Nyeem²,

Awal³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe hepatoprotective activity of the alcoholic extract of Rosa damascena was studied against paracetamol induced acute hepatotoxicity in rats. Liver damage was assessed by estimating serum enzyme activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and histopathology of liver tissue. Pre-and post-treatment with ethanolic extracts showed a dose-dependent reduction of paracetamol induced elevated serum levels of enzyme activity. The mechanism underlying the protective effects was assayed in vitro and the R. damascena extracts displayed dosedependent free radical activity using DPPH (IC 5 0 = 162.525 μg/ml) and TBA method. The hepatoprotective action was confirmed by histopathological observation. The ethanolic extracts reversed paracetamol induced liver injury. These results suggest that the hepatoprotective effects of R. damascena extracts are related to its antioxidative activity.

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Section: Preparation Of Ethanol Extractsmentioning

confidence: 99%

“…Antioxidant activity of the ethanolic extract of R. damascena was performed on the basis of the modified method of Gupta et al (2003). The extract showed excellent antioxidant activity (IC 50 about 162.525 µg/ml) against DPPH free radical comparable to that of standard drug, ascorbic acid (IC 50 about 64.307 mg/ml) (Fig.…”

Section: Antioxidant Assaymentioning

confidence: 99%

Antioxidant and hepatoprotective action of the crude ethanolic extract of the flowering top of Rosa damascena

Alam¹,

Nyeem²,

Awal³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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“…The test tubes were allowed to stand in the dark for 30 min to complete the reaction and then absorbance was recorded at 517 nm (Gupta et al, 2003). The decrease in absorbance with respect to the blank was also measured.…”

Section: Determination Of Dpph Free Radical Scavenging Activitymentioning

confidence: 99%

In Vitro Antioxidant Activity, Antimicrobial and Preliminary Cytotoxic Activity of Cynometra Ramiflora- A Mangrove Plant

Afrin¹,

Pervin²,

Sabrin³

et al. 2016

J microb biotech food sci

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A mangrove medicinal plant Cynometra ramiflora (Family: Leguminosae) was selected to investigate the bioactivities namely antioxidant, antimicrobial and preliminary cytotoxic activity using methanol and chloroform extracts of the leaves and stems, respectively. In 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, 50% inhibitory concentration (IC50) of the methanolic stem extract was found to be 31.62 µg.mL-1. Reducing power of the same extract demonstrated consistent increase in a concentration-dependent manner and was comparable with quercetin while ferric reducing antioxidant power (FRAP) assay revealed potential total antioxidant capacity (84.0 mM Fe (II)/g of extract). In addition, the presence of total phenolics (96.2 mg GAE/g of extract), total flavonoids (166.4 mg QE/g of extract) and tannins content (80.4 mg GAE/g of extract) were determined in the methanolic stem extract. The chloroformic stem extract exhibited moderate antimicrobial activity against a number of bacterial strains while the MIC values of extracts were in the range from 62.5 to 500µg.mL-1. The methanolic stem and leaf extracts demonstrated strong lethality in preliminary cytotoxicity assay using brine shrimp nauplii where the 50% lethal concentration (LC50) values were 1.596 and 4.613 µg.mL-1 respectively. It can be therefore concluded that the methanolic extracts of C. ramiflora possess potential antioxidant, antimicrobial and strong preliminary cytotoxic activity and could be further exploited for prospective scientific exploration towards bioactive principles.

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“…Then 2 mL of 0.004% DPPH solution was added in test tube of different extracts. The test tubes were allowed to stand at dark for 30 min to complete the reaction and then absorbance was recorded at 517 nm [16]. The decrease in absorbance with blank was also measured.…”

Section: Measurement Of Dpph Free Radical Scavenging Activitymentioning

confidence: 99%

Investigation of Antibacterial, Cytotoxic and Antioxidant Properties of the Mangrove Plant <i>Xylocarpus mekongensis</i>

Akter¹,

Afrin²,

Sakib³

et al. 2016

ABB

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The plant (Xylocarpus mekongensis) of the Sundarbans mangrove origin was evaluated for its antibacterial, cytotoxic and antioxidant properties using methanolic and chloroformic leaf, stem and bark extracts, respectively. The methanolic extracts contained higher amount of total phenolics, flavonoids, tannins than the chloroformic extracts and the result was in correlation with their ferric reducing power ability as well. However, the chloroformic bark extract contained more potent DPPH free radical scavenging activity than others. Antibacterial activity of the extracts was determined against both Gram-positive (Micrococcus and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Vibrio cholerae, Salmonella typhimurium and Salmonella paratyphi) by disc diffusion assay and their zone of inhibitions (ZOI) were measured. Moreover, their minimum inhibitory concentrations (MIC) were determined by tube dilution method. Chloroformic bark and stem extracts showed strong inhibition to growth of P. aeruginosa (ZOI = 19 mm and MIC = 150 µg/ml) and S. aureus (ZOI = 19.5 mm and MIC = 250 µg/ml), respectively. All six extracts were subjected to brine shrimp lethality bioassay for possible measure of cytotoxicity. Concentration dependent increment in percentage mortality of brine Shrimp nauplii produced by the extracts indicated the presence of cytotoxic principles in these extractives. Therefore, Xylocarpus mekongensis showed antioxidant, antibacterial and cytotoxic activities.

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ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF <i>ACALYPHA FRUTICOSA</i>

Cited by 33 publications

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Antioxidant and hepatoprotective action of the crude ethanolic extract of the flowering top of Rosa damascena

Antioxidant and hepatoprotective action of the crude ethanolic extract of the flowering top of Rosa damascena

In Vitro Antioxidant Activity, Antimicrobial and Preliminary Cytotoxic Activity of Cynometra Ramiflora- A Mangrove Plant

Investigation of Antibacterial, Cytotoxic and Antioxidant Properties of the Mangrove Plant <i>Xylocarpus mekongensis</i>

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ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF <i>ACALYPHA FRUTICOSA</i>

Cited by 33 publications

References 0 publications

Antioxidant and hepatoprotective action of the crude ethanolic extract of the flowering top of Rosa damascena

Antioxidant and hepatoprotective action of the crude ethanolic extract of the flowering top of Rosa damascena

In Vitro Antioxidant Activity, Antimicrobial and Preliminary Cytotoxic Activity of Cynometra Ramiflora- A Mangrove Plant

Investigation of Antibacterial, Cytotoxic and Antioxidant Properties of the Mangrove Plant &lt;i&gt;Xylocarpus mekongensis&lt;/i&gt;

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Investigation of Antibacterial, Cytotoxic and Antioxidant Properties of the Mangrove Plant <i>Xylocarpus mekongensis</i>