Antioxidant and anti-inflammatory activities of Prussian blue nanozyme promotes full-thickness skin wound healing

Ultrasmall Prussian blue nanoparticles attenuate UVA-induced cellular senescence in human dermal fibroblasts via inhibiting the ERK/AP-1 pathway

“…Based on above observation, 1 μg/ml USPBNPs was utilized in the subsequent experiments. It should be noted that the dose of USPBNPs in present study was much lower than that of PBNPs used in previously published work, 26,29,30 which can be attributed to its ultrasmall size.…”

“…25 In recent years, prussian blue nanoparticles (PBNPs) demonstrated efficient ability to remove excessive ROS by mimicking multiple enzymes and showed novel therapeutic role in skin wound healing, acute pancreatitis and anemia. [26][27][28][29][30] However, PBNPs still have shortcomings such as a relatively large size and weak catalytic activity. Fortunately, USPBNPs with a size of about 3.4 nm were successfully synthesized in our previous study, which exhibited a more intensive ability of scavenging ROS.…”

Prussian Blue Scavenger Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Inflammation and Reducing Oxidative Stress

“…PB scavenger is nonspecifically taken up by mononuclear phagocyte systems (e.g., liver, spleen), remove these particles from the circulation and resulting in the delivery of a sufficient dose of nano-antioxidants to the liver. In addition to protecting against acute liver injury, PB scavengers have been shown to have good therapeutic effects in ischemic stroke ( 21 ), wound healing ( 24 ) and inflammatory bowel disease ( 25 ), indicating its great potential for treating ROS-associated and inflammatory diseases. Evaluations of its mechanisms of action suggest that PB scavengers reduce intracellular ROS in hepatocytes and macrophages treated with various stimuli, suggesting that these may be critical mechanisms underlying the cytoprotective and anti-inflammatory properties or PB scavengers.…”

Hyaluronan-coated Prussian blue nanoparticles relieve LPS-induced peritonitis by suppressing oxidative species generation in tissue-resident macrophages

“…PB nanoparticles containing Fe 3+ cations and [Fe(CN) 6 ] 2+ degrade H 2 O 2 via the Fenton reaction. [18][19][20][21] However, it does not produce hydroxyl radicals since the oxidized PB will further react with excess peroxides and hydroxyl radicals to produce water and oxygen. 22 Previously, Zhang et al had elaborately elucidated the multienzyme-like activity of Prussian blue nanoparticles, such as peroxidase, catalase, and superoxide dismutase activities.…”