Antioxidant and anti-inflammatory activities of Lonicera japonica Thunb. var. sempervillosa Hayata flower bud extracts prepared by water, ethanol and supercritical fluid extraction techniques

Hsu, Hsia-Fen; Hsiao, Pei-Chi; Kuo, Tzu-Chen; Chiang, Shu-Tuan; Chen, Shin-Lung; Chiou, Shu-Jiau; Ling, Xue-Hua; Liang, Ming-Tsai; Cheng, Wei‐Yi; Houng, Jer-Yiing

doi:10.1016/j.indcrop.2016.05.010

Cited by 69 publications

(46 citation statements)

References 29 publications

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“…L. japonica is an important raw material of Flos Lonicerae Japonicae [named Jinyinhua (Flos Lonicerae) in Chinese], which has been used as a Traditional Chinese Medicine for the treatment of rheumatoid arthritis, hepatitis, carbuncles, furuncles, fever, and respiratory infections [3], and contained several active ingredients, such as polyphenols, avones, and triterpenoid saponins [4]. Galuteolin (Galu, also named Luteoloside), belonging to the avonoids, shows a broad spectrum of biological activities, including antibacterial, anti-viral anti-oxidant, anti in ammatory, anti-nociceptive and anti-angiogenic effects [5,6].…”

Section: Introductionmentioning

confidence: 99%

Galuteolin suppresses proliferation and inflammation in TNF-α-induced RA-FLS cells by activating HMOX1 to regulate IKKβ/NF-κB pathway

GUAN

ZHAO

LIU

et al. 2020

Preprint

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Objective: Galuteolin (Galu) is a substance extracted and purified from honeysuckle. The purpose of this study was to explore the effects of Galu on the TNF-α-induced RA-FLS cells (synoviocytes) and reveal its potential molecular mechanism from the perspectives of anti-apoptosis and anti-inflammation.Methods: After TNF-α stimulation, cell proliferation of RA-FLS was assessed by CCK-8 assay. TUNEL staining was used to detect the apoptosis. Western Blot was used to detect the expressions of Iκκβ, p-p65, p65, p-IκB, IκB, Cleaved-caspase3, Caspase-3, Bcl-2, and Bax. HO-1 were determined by RT-PCR. The contents of pro-inflammatory cytokines IL-1β, IL-6, IL-8 and MMP-1 were determined by ELISA.Results: Galu significantly suppressed cell proliferation in a dose-dependent manner. Additionally, Galu obviously promote cell apoptosis rate of RA-FLS cells and elevated the expression levels of HO-1, caspase-3 and Bax, while reduced the expression level of Bcl-2. Furthermore, Galu apparently inhibited the levels of Iκκβ, p-p65 and p-IκB. Moreover, Galu also significantly reduced the levels of pro-inflammatory factors IL-1β, IL-6, IL-8 and MMP-1 in RA-FLS cells. Conclusion: Galuteolin exerts protective effects against TNF-α-induced RA-FLS cells by inhibiting apoptosis and inflammation, which can guide the clinical use of rheumatoid arthritis.

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Section: Introductionmentioning

confidence: 99%

Galuteolin suppresses proliferation and inflammation in TNF-α-induced RA-FLS cells by activating HMOX1 to regulate IKKβ/NF-κB pathway

GUAN

ZHAO

LIU

et al. 2020

Preprint

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“…The chemical constituents of L. japonica have been identified as caffeoylquinic acids, secoiridoids, homosecoiridoids, nitrogen containing iridoids, flavonoids, saponins and cerebrosides . Among these compounds, secologanic acid is a major component but the biological activities of secologanic acid have been only reported to be for the inhibition of nitric oxide production in lipopolysaccharide (LPS)‐activated macrophages . Vogeloside and epivogeloside, unwanted products of secologanic acid, were found to exert a weak inhibitory effect on the growth of influenza A/PR/8/34 .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6] Among these compounds, secologanic acid is a major component but the biological activities of secologanic acid have been only reported to be for the inhibition of nitric oxide production in lipopolysaccharide (LPS)-activated macrophages. 7,8 Vogeloside and epivogeloside, unwanted products of secologanic acid, were found to exert a weak inhibitory effect on the growth of influenza A/PR/8/34. 9,10 Recently, HS-23, a Lonicerae Flos extract, improved sepsis-induced mortality via inhibition of IL-1 receptor-associated kinase 4, 11 suppression of toll-like receptor 4 signalling pathways 12 and inhibition of lymphocyte apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Large‐scale purification of unstable, water‐soluble secologanic acid using centrifugal partition chromatography

Yeon

Jeon

et al. 2018

Phytochemical Analysis

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“…The loss of compositions is difficult to count due to the heating transformation. Lonicera japonica Thunberg, a widely used traditional Chinese medicine, possesses antibacterial, antiviral, and antiendotoxin activities [1][2][3][4]. It was taken to treat the exopathogenic wind-heat, epidemic febrile diseases, sores, carbuncles and some infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Concentrating phenolic acids from Lonicera japonica by nanofiltration technology

Li¹,

Ma²,

Li³

et al. 2017

AIP Conference Proceedings

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ARTICLES YOU MAY BE INTERESTED INCrystallization of bovine insulin on a flow-free droplet-based platform AIP Conference Proceedings 1820, 030003 (2017) Abstract. Response surface analysis methodology was used to optimize the concentrate process of phenolic acids from Lonicera japonica by nanofiltration technique. On the basis of the influences of pressure, temperature and circulating volume, the retention rate of neochlorogenic acid, chlorogenic acid and 4-dicaffeoylquinic acid were selected as index, molecular weight cut-off of nanofiltration membrane, concentration and pH were selected as influencing factors during concentrate process. The experiment mathematical model was arranged according to Box-Behnken central composite experiment design. The optimal concentrate conditions were as following: nanofiltration molecular weight cut-off, 150 Da; solutes concentration, 18.34 μg/mL; pH, 4.26. The predicted value of retention rate was 97.99% under the optimum conditions, and the experimental value was 98.03±0.24%, which was in accordance with the predicted value. These results demonstrate that the combination of Box-Behnken design and response surface analysis can well optimize the concentrate process of Lonicera japonica water-extraction by nanofiltration, and the results provide the basis for nanofiltration concentrate for heat-sensitive traditional Chinese medicine.

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Antioxidant and anti-inflammatory activities of Lonicera japonica Thunb. var. sempervillosa Hayata flower bud extracts prepared by water, ethanol and supercritical fluid extraction techniques

Cited by 69 publications

References 29 publications

Galuteolin suppresses proliferation and inflammation in TNF-α-induced RA-FLS cells by activating HMOX1 to regulate IKKβ/NF-κB pathway

Galuteolin suppresses proliferation and inflammation in TNF-α-induced RA-FLS cells by activating HMOX1 to regulate IKKβ/NF-κB pathway

Large‐scale purification of unstable, water‐soluble secologanic acid using centrifugal partition chromatography

Concentrating phenolic acids from Lonicera japonica by nanofiltration technology

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