Antioxidant and anti–glycation activities correlates with phenolic composition of tropical medicinal herbs

Ramkissoon, J.S.; Mahomoodally, Mohamad Fawzi; Ahmed, Nessar; Subratty, A.H.

doi:10.1016/s1995-7645(13)60097-8

Cited by 133 publications

(104 citation statements)

References 35 publications

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“…The results from this study revealed that the all prepared extracts possessed antiprotein glycation. These findings correlated with those reported by other investigators about antiglycation efficacy of some natural plants, such as Allium cepa L. [32] , Curcuma longa L. [33] , Rosmarinus officinalis L. [34] , Cinnamomum verum [35] and Origanum officinalis [36] under in vitro conditions. Under identical conditions, the antiglycation potential of extracts on albumin was higher than hemoglobin, and crystalline glycation, respectively.…”

Section: Resultssupporting

confidence: 91%

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Faezizadeh¹,

Ghorbanihaghjo²,

Godarzee³

2016

ijps

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Faezizadeh, et al.: Antiglycation Effects of Some Boraginaceae SpeciesNon-enzymatic glycation of proteins is the major cause of diabetic complications and therefore, inhibition of this reaction could reduce the morbidity of this disease. The aim of this study was to evaluate the in vitro effects of aqueous and hydroethanol extracts of Echium italicum L., Anchusa arvensis L. and Trichodesma incanum (Bunge) A. DC. of Boraginaceae on albumin, hemoglobin, and crystalline glycation reaction. The results showed that the hydroethanol extract of Echium italicum in the concentrations of 100, 50 and 10 mg/dl could reduce the rate of albumin glycation to 85.10±1.85, 64.14±1.12 and 40.13±1.17%, respectively, and also in the same conditions, rates of hemoglobin glycation were reduced to 69.20±1.71, 46.13±1.93 and 27.73±0.90%, respectively. Moreover, extracts of three tested plants have antiglycation effects on crystalline glycation reaction. Under the identical conditions, the inhibitory effects of hydroethanol extracts of Echium italicum on the albumin, hemoglobin, and crystalline glycation reaction were higher than other extracts. The findings showed that the extracts of tested species, particularly in the hydroethanol form, could be used to prevent and treat complications of diabetes mellitus. Key words: Echium italicum L., Anchusa arvensis L., Trichodesma incanum (Bunge) A. DC., albumin, hemoglobin, glycationMembers of the family Boraginaceae include herbs, shrubs and trees totaling about 146 genera and 2000 species in the worldwide [1] . Some of these plants grow in Iran and used widely in Iran's folk medicine [2,3] . It has been reported that Borage (Borago officinalis L.) was useful for its antipyretic, antihypertensive, antispasmodic, aphrodisiac and diuretic properties [4,5] . Previous findings showed that some species of Boraginaceae were used for the treatment of hemorrhoids [6] . Furthermore, it has also been observed that various parts of Echium species could be used for their antiinflammatory, antibacterial, antidepressant, antiproliferative, antiviral, antioxidant, cytotoxic and anxiolytic properties [2,3] . Cyanidin, a natural phenolic compound is present in many kinds of plants, such as grapes, pomegranate and some species of Boraginaceae and according to the previous reports, this effective compound has antioxidant and antidiabetic potential [7][8][9][10] .Diabetes mellitus is a common endocrine disease and a leading cause of morbidity and mortality in the world [11] . In this disease, the macro and microvascular complications lead to severe effects on the eyes, central nervous systems and kidneys [12] . Evidence from in vitro and in vivo experiments indicated that diabetic hyperglycemia could increase the risk of complications [13,14] . It seems that non-enzymatic glycation plays an important role in progression of diabetic complications [11] . Due to prolonged hyperglycemia, the non-enzymatic glycation of proteins could significantly change their structural and functional properties [12] . Previous studie...

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Section: Resultssupporting

confidence: 91%

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Faezizadeh¹,

Ghorbanihaghjo²,

Godarzee³

2016

ijps

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“…The high positive correlation between antiglycation and antioxidative activities of spices in BSA-glucose model system was confirmed (TPC/BSA-glucose, r=0.9; DPPH/BSA-glucose, r=0.6) by Ramkissoon et al [2013]. Our observations on the antiglycation effect related to buckwheat are in agreement with our earlier research in which the inhibitory effect of buckwheat-enhanced wheat breads against AGEs formation in BSA-glucose and BSA-MGO systems was dependent on the level of the substitution of dark or white wheat flours with buckwheat flour in wheat bread formulas [Szawara- Table 1).…”

Section: Correlation Studiesmentioning

confidence: 79%

“…. However, the high AGEs inhibitory potential of coriander (one ingredient of spice mix) was noted [Ramkissoon et al, 2013]. It means that also each spice from the spice mix for gingerbreads may contribute to the total antiglycation ability of rye-buckwheat ginger cakes.…”

Section: Correlation Studiesmentioning

confidence: 99%

“…Green tea and tea infused with selected herbs [Ho et al, 2010], tomato paste [Kiho et al, 2004] or spices [Tosun & Khan, 2015] was highlighted as a potential inhibitor of AGEs formation. Therefore, the positive correlation between anti-glycation potential and antioxidant properties in herbs was observed [Ramkissoon et al, 2013]. Searching for inhibitors of AGEs formation, focus is put on polyphenols.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the In Vitro Inhibitory Activity of Rye-Buckwheat Ginger Cakes with Rutin on the Formation of Advanced Glycation End-Products (AGEs)

Przygodzka¹,

Zieliński²

2015

Pol. J. Food Nutr. Sci.

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In this study, the relationship between the inhibitory effects of extracts from rye-buckwheat ginger cakes supplemented with low and high rutin dosage baked without or with dough fermentation step on the formation of fluorescent advanced glycation end-products (AGEs), and phenolic compounds, rutin, D-chiro-inositol and antioxidant capacity were addressed. The cakes were based on rye flour substituted by light buckwheat flour or flour from roasted buckwheat groats at 30% level, and were produced with or without dough fermentation step. The inhibitory effect against AGEs formation was studied in bovine serum albumin (BSA)-glucose and BSA-methylglyoxal (MGO) systems. The antioxidant capacity was measured by 2,2-diphenyl--1-picrylhydrazyl (DPPH) and cyclic voltammetry (CV), rutin and D-chiro-inositol contents by HPLC and total phenolics (TPC) by spectrophotometric assays. The study showed the inhibitory effects of extracts from rye-buckwheat ginger cakes supplemented with low and high rutin dosage. The results of the inhibitory activity were highly correlated in two applied model systems. Enrichment of rye-buckwheat ginger cakes with rutin improved their antioxidant properties. The correlation studies showed that the inhibitory effects of rye-buckwheat ginger cakes produced with dough fermentation step and enhanced with rutin against formation of AGEs were highly correlated with TPC, rutin and D-chiro-inositol contents, and antioxidant capacity. Moreover, the effect of rutin enrichment was clearly seen in cakes obtained with dough fermentation step, even the inhibitory activity was slightly lower as compared to the cakes produced without dough fermentation.

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“…Antimicrobial (Bouari et al 2014), antibiofilm and antifungal effects (Saharkhiz et al 2012) along with cytotoxic effect on cancer cells (Hussain et al 2010;Berdowska et al 2013) and anxiolytic (Kravchenko et al 2012) capacities were reported. Its proapoptotic in yeast via cytosolic and mitochondrial ROS-mediated damage (Ferreira et al 2014); acetylcholine esterase inhibitory and antioxiadtive (VladimirKnežević et al 2014) with antiglycation (Ramkissoon et al 2013) properties. Neuroprotective (Hassan et al 2013) and antinociceptive activity (Taher 2012) were proved.…”

Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

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Context National statistical reports in Jordan indicate a decrease in the total fertility rate along with a parallel increase in contraceptive use. The folkloric use of medicinal herbs in gynecological disorders has been growing in Jordan, despite of deficient reports on the evidence-based safety and efficacy of these practices. Objective The aim of this comprehensive article is to review medicinal plants with claimed ethnonpharmacological usage in various gynecological and pregnancy-related issues in Jordan, and to assess their evidence-based pharmacological studies as well as their phytochemistry. Methods The published literature was surveyed using Google Scholar entering the terms ''ethnopharmacology AND Jordan AND infertility AND gynecology OR gestation''. We included ethnopharmacological surveys in Jordan with available full-text. Results Twelve articles were reviewed. Plant species which are commonly used for female gynecological issues such as Artemisia monosperma Del. and A. herba-alba Asso. (Asteraceae) have been found to exert an antifertility effect. Ricinus communis L. (Euphorbiaceae) and Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) had antifertility effects in male rats, but Nigella sativa oil L. (Ranunculaceae) and Cinnamon zeylanicum J. Presl (Lauraceae) were found to enhance it. Conclusion Using plants for gynecological disorders is a common practice in Jordan. Many of them, whether utilised for gynecological or non-gynecological conditions equally, were found to have detrimental effects on female or male fertility. Thus, couples planning pregnancy should be discouraged from the consumption of these herbs. Further local studies are warranted to confirm the appreciable beneficial pharmacological effects and safety of these plants. ARTICLE HISTORY

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Antioxidant and anti–glycation activities correlates with phenolic composition of tropical medicinal herbs

Abstract: The positive glycation inhibitory and antioxidative activities of these tropical herbs suggest a possible role in targeting ageing, diabetic complications and oxidative stress related diseases.

Cited by 133 publications

References 35 publications

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Evaluation of the In Vitro Inhibitory Activity of Rye-Buckwheat Ginger Cakes with Rutin on the Formation of Advanced Glycation End-Products (AGEs)

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

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