Antioxidant and Anti-Anemic Effects of Ethanol Leaf Extracts of Mucuna poggei and Telfairia occidentalis in Phenyl-Hydrazine-Induced Anemia in Wistar Albino Rats

Udeozor, Precious A.; Ibiam, U. A.; Uti, Daniel Ejim; Umoru, Grace Ufedo; Onwe, Eucharia N.; Mbonu, Francis O.; Omang, Wilson A.; Ijoganu, Samuel I.; Anaga, Charles O.; Mbah, Jenavine Onyinye; Nwadum, Solomon K.

doi:10.1055/s-0042-1756684

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…Hb plays a pivotal role as the respiratory pigment within RBCs, and intravascular hemolysis of RBCs leads to the release of hemoglobin and the accumulation of free heme . Moreover, it has been established that phenylhydrazine can bind to erythropoietin receptors, a hormone that regulates hematopoiesis and promotes erythrocyte production . PC-Ext contains substances capable of acting similarly to erythropoietin by binding to its receptors, potentially competing with PhZ, or using an alternative mechanism to stimulate erythrocyte production.…”

Section: Discussionmentioning

confidence: 99%

“… 50 Moreover, it has been established that phenylhydrazine can bind to erythropoietin receptors, a hormone that regulates hematopoiesis and promotes erythrocyte production. 51 PC-Ext contains substances capable of acting similarly to erythropoietin by binding to its receptors, potentially competing with PhZ, or using an alternative mechanism to stimulate erythrocyte production. Furthermore, the partial or complete restoration of MCV and MCHC suggests that parsley facilitates the normalization of erythrocyte size and hemoglobin content, indicative of enhanced cell multiplication and normal hemoglobin synthesis.…”

Section: Discussionmentioning

confidence: 99%

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Unveiling the Antianemic Activity, Physicochemical Aspects, Antioxidant Properties, and Mineral Profile of Petroselinum crispum L

Nouioura,

Lafdil,

Kandsi

et al. 2024

ACS Omega

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unveiling the Antianemic Activity, Physicochemical Aspects, Antioxidant Properties, and Mineral Profile of Petroselinum crispum L

Nouioura,

Lafdil,

Kandsi

et al. 2024

ACS Omega

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“…19 The catalase activity was determined by the method of Beers and Sizer. 20 The reduced glutathione in the tissue was determined by the method of Moron et al 21 The malondialdehyde of the tissue was determined as earlier reported by Udeozor et al 22…”

Section: Oxidative Stress Indicatorsmentioning

confidence: 99%

Xylopia aethiopica Attenuates Oxidative Stress and Hepatorenal Damage in Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Ibiam,

Uti,

Ejeogo

et al. 2024

Journal of Health and Allied Sciences NU

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Objectives Xylopia aethiopica (XAE), commonly known as African pepper or Ethiopian pepper, is a plant native to West Africa and known for its aromatic and medicinal properties. It was used to investigate the antioxidative, antihepatotoxic, and antinephrotoxic potentials of XAE in benign prostatic hyperplasia (BPH) in Wister albino rats. Methods The proximate, and vitamin composition, oxidative stress indicators, and indices of kidney and hepatic functions were performed by standard methods. Results The proximate composition of the XAE leaf showed varied concentrations of Mg, Ca, Na, Zn, Se, and Cl, as well as vitamins A, E, B3, D, C, K, B2, and Bi. The activities of catalase glutathione, superoxide dismutase, malondialdehyde levels, K, Na, Cl−, urea, uric acid, and creatinine in the kidney were increased in testosterone propionate (Tp)-induced BPH compared with the control groups. Total protein levels significantly decreased in Tp-induced BPH compared with XAE-treated groups increased on XAE treatment. The aspartate transaminase, alanine aminotransferase, and alkaline phosphatase activities were not significantly different in Tp-induced BPH, XAE, and normal controls. Conclusion The study revealed that XAE can be used in the management of oxidative stress and hepatorenal damage in BPH condition.

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“…The CAT activity was assayed according to the method described by Udeozor et al 27 . In brief, 2.5 mL of phosphate buffer and 2 mL of H 2 O 2 were added to the test tube exactly at the same times.…”

Section: Determination Of Catalase (Cat) Activitymentioning

confidence: 99%

Cocos nucifera Water Ameliorated Hepatic Complications and Attenuated Oxidative Stress in Cadmium-Induced Hepatotoxicity

Nwadum,

Ibiam,

Uti

et al. 2023

Asian J. Biol. Sci

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Background and Objectives: Cadmium (Cd) is a heavy metal widely distributed in the environment due to industrial, agricultural and natural sources. Chronic exposure to cadmium is known to induce hepatotoxicity, leading to severe liver damage and dysfunction. Hence, the effect of Cocos nucifera water on indices of liver function and oxidative stress in cadmium-induced hepatotoxicity was investigated in albino rats. Materials and Methods: The study involved 30 Wistar rats divided into 6 groups, with control groups receiving normal saline. Hepatotoxicity was induced in groups B, D, E and F by oral cadmium administration. Group B remained untreated, while groups D through F were treated with varying doses of Cocos nucifera water. The proximate, vitamin and mineral contents of Cocos nucifera water were determined. Results: The cadmium administration to rats increased hepatic enzyme activities, decreased catalase and reduced glutathione levels. However, treatment with Cocos nucifera water significantly decreased these effects and restored liver architecture to normal. The study confirmed that cadmium can be a potential health risk for humans. Conclusion: The Cocos nucifera water maybe beneficial in treating liver complications.

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Antioxidant and Anti-Anemic Effects of Ethanol Leaf Extracts of Mucuna poggei and Telfairia occidentalis in Phenyl-Hydrazine-Induced Anemia in Wistar Albino Rats

Cited by 7 publications

References 31 publications

Unveiling the Antianemic Activity, Physicochemical Aspects, Antioxidant Properties, and Mineral Profile of Petroselinum crispum L

Unveiling the Antianemic Activity, Physicochemical Aspects, Antioxidant Properties, and Mineral Profile of Petroselinum crispum L

Xylopia aethiopica Attenuates Oxidative Stress and Hepatorenal Damage in Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Cocos nucifera Water Ameliorated Hepatic Complications and Attenuated Oxidative Stress in Cadmium-Induced Hepatotoxicity

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