Antioxidant and Anti-adipogenic Effects of PineXol<sup>®</sup>

이영준,; 한완택,; 최현선,; 이부용,; 정현정,; 이옥환,

doi:10.9721/kjfst.2013.45.1.97

Cited by 20 publications

(17 citation statements)

References 20 publications

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“…It is in accordance with the above given scope that PineXol (PX) (Nutrapharm Co., Korea), extracted from Korean Red Pine (Pinus densiflora) bark, has been reported to have similar beneficial functions to pycnogenol, including antioxidant, anti-inflammation, and anti-lipogenic effects in vitro [28,29]. According to HPLC analysis, because the phenolic compounds (catechin and taxifolin) and flavonoid (procyanidin B1 and B2) contents are comparable, the similarity of PX and Pycnogenol composition is high [30,31].…”

Section: Introductionsupporting

confidence: 67%

“…The PX 75 μg/ml and PX 100 μg/ml treatment groups showed a decline in lipid accumulation by approximately 36% and 40%, respectively, in comparison with the CTL group (p < 0.05). Lipid accumulation in the PX-treated groups (50, 100, and 200 μg/ml) was considerably more inhibited than in the control group for 3T3-L1 [29]. Western blot analysis for proteins related to adipogenesis was conducted to examine the given mechanism.…”

Section: Lipid Accumulation Reduction In 3t3-l1 Adipocytes By Pxmentioning

confidence: 99%

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Downregulation of Hepatic De Novo Lipogenesis and Adipogenesis in Adipocytes by Pinus densiflora Bark Extract

Ahn

Jeong

Moyo

et al. 2017

Journal of Microbiology and Biotechnology

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Korean red pine () bark extract, PineXol (PX), was investigated for its potential antioxidant and anti-inflammation effects in vitro. It was hypothesized that PX treatment (25-150 μg/ml) would reduce the lipid synthesis in HepG2 hepatocytes as well as lipid accumulation in 3T3-L1 adipocytes. Hepatocytes' intracellular triglycerides and cholesterol were decreased in the PX 150 μg/ml treatment group compared with the control ( < 0.05). Consequently, de novo lipogenic proteins (acetyl-CoA carboxylase 1, stearoyl-CoA desaturase 1, elongase of very long chain fatty acids 6, glycerol-3-phosphate acyltransferase 1, and sterol regulatory element-binding protein 1) were significantly decreased in hepatocytes by PX 150 μg/ml treatment compared with the control ( < 0.05). In differentiated 3T3-L1 adipocytes, the lipid accumulation was significantly attenuated by all PX treatments ( < 0.01). Regulators of adipogenesis, including CCAAT-enhancer-binding proteins alpha, peroxisome proliferator-activated receptor gamma, and perilipin, were decreased in PX 100 μg/ml treatment compared with the control ( < 0.05). In conclusion, PX might have anti-obesity effects by blocking hepatic lipogenesis and by inhibiting adipogenesis in adipocytes.

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Section: Introductionsupporting

confidence: 67%

Section: Lipid Accumulation Reduction In 3t3-l1 Adipocytes By Pxmentioning

confidence: 99%

Downregulation of Hepatic De Novo Lipogenesis and Adipogenesis in Adipocytes by Pinus densiflora Bark Extract

Ahn

Jeong

Moyo

et al. 2017

Journal of Microbiology and Biotechnology

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“…Levels of C/EBPα, PPARγ, and perilipin were clearly suppressed in the PineXol-treated groups, suggesting that PineXol could be used to prevent obesity. Previous studies have reported similar antilipogenic effects in vitro: PineXol and Pycnogenol, for example, both inhibit lipid accumulation in 3T3-L1 adipocytes [16,23]. Pycnogenol decreases the levels of perilipin A and H89 (a PKA inhibitor) in both ob/ob mice and primary adipocytes [21].…”

Section: Discussionmentioning

confidence: 59%

“…PineXol (Nutrapharm Co., Korea), extracted from the bark of Korean red pine (Pinus densiflora), has been reported to have similar beneficial effects, including antioxidant, antiinflammatory, and antilipogenic activities in vitro [22,23]. The composition of PineXol is similar to that of Pycnogenol, with comparable phenolic compounds (catechin and taxifolin) and flavonoids (procyanidin B1 and B2), according to HPLC analyses [24,25].…”

Section: Introductionmentioning

confidence: 99%

Pinus Densiflora Bark Extract (PineXol) Decreases Adiposity in Mice by Down-Regulation of Hepatic De Novo Lipogenesis and Adipogenesis in White Adipose Tissue

Ahn¹,

Go²

2017

Journal of Microbiology and Biotechnology

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PineXol, extracted from Korean red pine bark, has beneficial effects, such as antioxidant, antiinflammatory, and antilipogenic activities in vitro. We tested the hypothesis that PineXol supplementation could have anti-obesity effects on mice fed a high-fat diet (HFD). Four-week-old male C57BL/6 mice were fed normal chow (18% kcal from fat) or a HFD (60% kcal from fat). HFD-fed animals were also subjected to PineXol treatment at a dose of 10 or 50 mg/kg body weight (BW) (PX10 or PX50, respectively) body weight. The body weight and body fat mass in the PX50 group were statistically lower than those in the HFD group ( < 0.05 and < 0.001, respectively). The concentration of hepatic triglycerides, total cholesterol, and low-density lipoprotein cholesterol were reduced in the PX50 group compared with the HFD group ( < 0.01). Acetyl CoA carboxylase ( < 0.01), elongase of very long chain fatty acids 6 ( < 0.01), stearoyl CoA desaturase 1 ( < 0.05), microsomal triglyceride transfer protein ( < 0.01), and sterol regulatory element-binding protein 1 ( < 0.05) were significantly decreased in the PX50 group compared with that in the HFD group. In white adipose tissue, CCAATenhancer-binding protein alpha ( < 0.05), peroxisome proliferator-activated receptor gamma ( < 0.001), and perilipin ( < 0.01) were decreased in the PX50 group compared with those in the HFD group. Therefore, the current study implies the potential of PineXol for the prevention and/or amelioration of obesity, in part by inhibition of both hepatic lipid synthesis and adipogenesis in white adipose tissue.

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“…Furthermore, excessive ROS generation is associated with increased lipid accumulation during adipocyte differentiation ( 33 , 34 ). Previous studies reported excessive differentiation of 3T3-L1 cells induced by transition metals (Cu 2+ or Fe 2+ ), due to increased expression of adipogenic transcriptional factors related to the NADPH-dependent H 2 O 2 -generating system ( 35 ). Thus, we investigated the inhibitory effect of WGE and F-WGE treatment on adipogenesis in 3T3-L1 cells.…”

Section: Discussionmentioning

confidence: 99%

Anti-Oxidant and Anti-Adipogenic Effects of Ethanol Extracts from Wheat Germ and Wheat Germ Fermented with Aspergillus oryzae

Park

Kim

et al. 2015

JFN

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Most of the wheat germ in cereal grains is removed during the milling process. Various physiological effects have been reported for bioactive substances in wheat germ such as phenolic acids and flavonoids. In this study, the anti-oxidant and anti-adipogenic effects of ethanol extracts from wheat germ (WGE) and wheat germ fermented with Aspergillus oryzae (F-WGE) were investigated in HepG2 and 3T3-L1 cells. The anti-oxidant activity of F-WGE was demonstrated by a dose-dependent increase in the enhanced scavenging capacity of hydroxyl radicals and Cu2+-chelating activity compared to WGE. WGE and F-WGE treatment at doses between 10 and 400 μg/mL did not affect the viability of HepG2 and 3T3-L1 cells. Intracellular ROS levels from Cu2+-induced oxidative stress were significantly decreased by F-WGE treatment in HepG2 cells compared to WGE. Lipid accumulation was increased in 3T3-L1 adipocytes by 100 μM Fe2+ treatment, but the accumulation was strongly inhibited by 100 μg/mL of WGE and F-WGE treatment. These results suggest that changes in bioactive substances during the fermentation of wheat germ can potentiate scavenging activities against transition metal-induced oxidative stress and lipid accumulation in 3T3-L1 adipocytes. Therefore, we propose that F-WGE is a novel food materials and provided scientific evidences for its efficacy in the development of functional foods.

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Antioxidant and Anti-adipogenic Effects of PineXol^®

Cited by 20 publications

References 20 publications

Downregulation of Hepatic De Novo Lipogenesis and Adipogenesis in Adipocytes by Pinus densiflora Bark Extract

Downregulation of Hepatic De Novo Lipogenesis and Adipogenesis in Adipocytes by Pinus densiflora Bark Extract

Pinus Densiflora Bark Extract (PineXol) Decreases Adiposity in Mice by Down-Regulation of Hepatic De Novo Lipogenesis and Adipogenesis in White Adipose Tissue

Anti-Oxidant and Anti-Adipogenic Effects of Ethanol Extracts from Wheat Germ and Wheat Germ Fermented with Aspergillus oryzae

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Antioxidant and Anti-adipogenic Effects of PineXol®

Cited by 20 publications

References 20 publications

Downregulation of Hepatic De Novo Lipogenesis and Adipogenesis in Adipocytes by Pinus densiflora Bark Extract

Downregulation of Hepatic De Novo Lipogenesis and Adipogenesis in Adipocytes by Pinus densiflora Bark Extract

Pinus Densiflora Bark Extract (PineXol) Decreases Adiposity in Mice by Down-Regulation of Hepatic De Novo Lipogenesis and Adipogenesis in White Adipose Tissue

Anti-Oxidant and Anti-Adipogenic Effects of Ethanol Extracts from Wheat Germ and Wheat Germ Fermented with Aspergillus oryzae

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Product

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Antioxidant and Anti-adipogenic Effects of PineXol^®