Antioxidant and anti-acetylcholinesterase potential of artichoke phenolic compounds

El-Aziz, Nourhan M. Abd; Awad, Olfat; Shehata, Mohamed G.; El-Sohaimy, Sobhy A.

doi:10.1016/j.fbio.2021.101006

Cited by 20 publications

(26 citation statements)

References 57 publications

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“…This huge production of orange juice worldwide produces a large amount of waste of peels, membranes, and seeds. This waste is mainly used as animal feed or discarded in the environment (Abd El-Aziz et al, 2021;…”

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confidence: 99%

Optimization conditions of ultrasound‐assisted extraction of phenolic compounds from orange peels using response surface methodology

Shehata

Aziz

Youssef

et al. 2021

J. Food Process. Preserv.

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Orange juice production is progressively increasing worldwide every year, except in 2020 due to the coronavirus disease 2019 pandemic. The global orange juice production in 2019 was about 2.2 million metric tons (Citrus: World Markets and Trade, July 2020; The European Fruit Juice Association). This huge production of orange juice worldwide produces a large amount of waste of peels, membranes, and seeds. This waste is mainly used as animal feed or discarded in the environment (Abd El-Aziz et al., 2021;

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mentioning

confidence: 99%

Optimization conditions of ultrasound‐assisted extraction of phenolic compounds from orange peels using response surface methodology

Shehata

Aziz

Youssef

et al. 2021

J. Food Process. Preserv.

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“…Commercial standards of corilagin, a compounds abounded in methanol extract, were reported to have AChE inhibitory effects with IC 50 values of 0.72 ± 0.03 mM [ 60 ]. In addition, Abd El-Aziz, et al [ 61 ] showed that ellagic acid exert competitive inhibition of AChE with IC 50 of 1.927 mg/mL. However, the phytochemical profiles presented here are qualitative only.…”

Section: Resultsmentioning

confidence: 67%

LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure

Świątek

Sieniawska

Sinan

et al. 2021

IJMS

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This study focused on the biological evaluation and chemical characterization of Geranium pyrenaicum Burm. f. Different solvent extracts (hexane, ethyl acetate, methanol, and water extracts) were prepared. The phytochemical profile, antioxidant, and enzyme inhibitory activity were investigated. Cytotoxicity was assessed using VERO, FaDu, HeLa and RKO cells. The antiviral activity was carried out against HSV-1 (Herpes simplex virus 1) propagated in VERO cell line. The aqueous extract, possessing high phenolic content (170.50 mg gallic acid equivalent/g extract), showed the highest reducing capacity (613.27 and 364.10 mg Trolox equivalent/g extract, for cupric reducing antioxidant capacity and ferric reducing antioxidant power, respectively), radical scavenging potential (469.82 mg Trolox equivalent/g extract, against 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)), metal chelating ability (52.39 mg ethylenediaminetetraacetic acid equivalent/g extract) and total antioxidant capacity (3.15 mmol Trolox equivalent/g extract). Liquid chromatography-electrospray ionization-quadrupole time-of-flight-mass spectrometry (LC-ESI-QTOF-MS/MS) alloved to tentatively identify a total of 56 compounds in the extracts, including ellagitannins, gallic acid and galloyl derivatives amongst others. The ethyl acetate extracts substantially depressed cholinesterase enzymes (4.49 and 12.26 mg galantamine equivalent/g extract against AChE and BChE, respectively) and α-amylase enzyme (1.04 mmol acarbose equivalent/g extract). On the other hand, the methanolic extract inhibited tyrosinase (121.42 mg kojic acid equivalent/g extract) and α-glucosidase (2.39 mmol acarbose equivalent/g extract) activities. The highest selectivity towards all cancer cell lines (SI 4.5–10.8) was observed with aqueous extract with the FaDu cells being the most sensitive (CC50 40.22 µg/mL). It can be concluded that the presence of certain bioactive antiviral molecules may be related to the high anti HSV-1 activity of the methanolic extract. This work has generated vital scientific data on this medicinal plant, which is a prospective candidate for the creation of innovative phyto-pharmaceuticals.

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“…It reduces infection via inhibiting the cyclooxygenase enzyme (COX), which participates in the synthesis of anti-inflammatory prostaglandins. Confirmed its capability to reduce Aβ aggregation and modulate its clearance from the brain 36 . Other neuroprotective phenolic compounds are anthocyanins.…”

Section: Phenolic Compoundsmentioning

confidence: 81%

A Review on: Alzheimer’s disease and mechanistic insights of bioactive compounds in its treatment

Kumar¹

2022

YMER

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Alzheimer’s disease is a most common neurological disorder, associated with cognitive disorder. Pathologically, Alzheimer's disease is characterized via the presence of β-amyloid (Aβ) plaques, hyper-phosphorylated tau proteins, and neurofibrillary tangles, but persistence oxidative-nitrative stress, endoplasmic reticulum pressure, mitochondrial disorder, inflammatory cytokines, pro-apoptotic proteins in conjunction with altered neurotransmitters degree are common etiological attributes in its pathogenesis. With the modern state of affairs, the variety of published proofs shows the neuroprotective capability of evidently occurring bioactive molecule via their anti-oxidant, ant apoptotic and neutransmitter modulatory residences. Many researchers have counselled that change of life style, proper diet, can delay or prevent the onset of this ailment. Diet is presently considered to be an important component in controlling fitness and protecting oneself towards oxidative strain and persistent inflammation, and hence towards chronic degenerative illnesses. A wide variety of bioactive food compounds may impact the pathological mechanisms underlying AD. Among them, phenolic compounds, omega-three fatty acids, fats-soluble vitamins, isothiocyanates, seem like the best in stopping neurodegeneration. The present review gathers proof that helps the neuroprotective impact of bioactive materials. Keywords: Alzheimer’s disease, neurodegeneration, amyloid cascade, tau protein, tau hypothesis, nitric oxide

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Antioxidant and anti-acetylcholinesterase potential of artichoke phenolic compounds

Cited by 20 publications

References 57 publications

Optimization conditions of ultrasound‐assisted extraction of phenolic compounds from orange peels using response surface methodology

Optimization conditions of ultrasound‐assisted extraction of phenolic compounds from orange peels using response surface methodology

LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure

A Review on: Alzheimer’s disease and mechanistic insights of bioactive compounds in its treatment

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