Antioxidant and acetylcholinesterase inhibitory activity of selected southern African medicinal plants

Adewusi, Emmanuel Adekanmi; Moodley, Nivan; Steenkamp, Vanessa

doi:10.1016/j.sajb.2010.12.009

Cited by 81 publications

(73 citation statements)

References 30 publications

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“…Thereafter, the aqueous solution was cooled at room temperature. Total phenolic content of tea extracts obtained at different brewing time were determined by the Folin-Ciocalteu method described in Adewusi et al (2011).…”

Section: Total Water Soluble Polyphenolsmentioning

confidence: 99%

Nutritional quality and acceptability of Buddleja saligna herbal tea

2015

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There is a growing interest in herbal teas due to their health promoting properties. In this study, chemical composition, antioxidant activity and consumer acceptance of Buddleja saligna herbal teas were determined. Protein (14 g/ 100 g) and carbohydrate (85 g/ 100 g) were the major nutrients in fresh leaves and processed green, oolong and black teas. Ash, crude fiber and lipids were very low in all samples. Fe contents of oolong and black (28 mg/100 g) were almost twice that of fresh leaves. Green tea infusions showed the highest total phenolic contents (5 GAE g/ml), which were twice those of oolong and black teas. By DDPH (2,2-diphenyl-1-picrylhydrazyl) assay, black tea infusion exhibited a slightly high radical scavenging activity (81.5 %±3.8) compared to green tea (78.6±3.7) and oolong (78.4±2.8). Oolong tea and black teas were the most liked for their taste and mouth feel compared to green tea.

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Section: Total Water Soluble Polyphenolsmentioning

confidence: 99%

Nutritional quality and acceptability of Buddleja saligna herbal tea

2015

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“…Antioxidant activity and free radical scavenging activity has been reported for various Clerodendrum species: C. infortunatum [39], C. siphonathus [40] and C. glandulosum [41]. The antioxidant activity noted for the methanol and ethyl acetate bark extracts of S. brachypetala is supported by studies where antioxidant and hydroxyl radical scavenging activity have been reported for the aqueous bark extracts of this plant [42,43]. Isolated compounds from this plant with known antioxidant activity include stilbenes and phenolics [44].…”

Section: Resultsmentioning

confidence: 88%

In vitro determination of the anti-aging potential of four southern African medicinal plants

Ndlovu

Fouché

Tselanyane

et al. 2013

BMC Complement Altern Med

102

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BackgroundAging is an inevitable process for all living organisms. During this process reactive oxygen species generation is increased which leads to the activation of hyaluronidase, collagenase and elastase, which can further contribute to skin aging. Four southern African medicinal plants; Clerodendrum glabrum, Schotia brachypetala, Psychotria capensis and Peltophorum africanum, were investigated to assess their anti-aging properties.MethodsAnti-elastase, anti-collagenase and anti-hyaluronidase activities of twenty-eight samples, consisting of methanol and ethyl acetate extracts of the four plants, were determined using spectrophotometric methods. Radical scavenging activity was determined by the ability of the plant extracts to scavenge the ABTS•+ radical.ResultsThe majority of the samples in the anti-elastase assay and nine in the anti-collagenase assay showed more than 80% inhibition. The ethyl acetate extract of S. brachypetala bark and leaves of P. capensis inhibited elastase activity by more than 90%. The methanol extract of S. brachypetala bark contained the highest anti-hyaluronidase activity (75.13 ± 7.49%) whilst the ethyl acetate extract of P. africanum bark exhibited the highest antioxidant activity (IC50: 1.99 ± 0.23 μg/ml).ConclusionThe free radical scavenging activity and enzyme inhibitory activity of the plant extracts investigated suggests that they can help restore skin elasticity and thereby slow the wrinkling process. P. africanum was the plant with the most promising activity and will be subjected to further testing and isolation of the active compound/s.

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“…Biochemical parameters like TBARS, GSH, and CAT activities were selected for monitoring oxidative status in mouse brain homogenate in line with earlier studies [51][52][53][62][63][64]. The elevated level of AChE has been suggested as a pathogenic factor for memory deficit [65,66]. Hence, the effect of drug interventions was also monitored on brain AChE activity.…”

Section: Discussionmentioning

confidence: 99%