Antioxidant activity of water-soluble chitosan derivatives

Xie, Wenming; Xu, Pengcheng; Liu, Qing

doi:10.1016/s0960-894x(01)00285-2

Cited by 547 publications

(290 citation statements)

References 8 publications

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“… OH can react with the residual free amino groups NH 2 to form stable macromolecule radicals. (Xie et al, 2001) In our testing material, the ideal source of hydrogen atom coming from -NH 2 and -OH groups that distributed along the backbone of the polymer, under acidic condition (pH ~ 4) amine groups in chitosan protonated, that decrease its contribution to scavenge radical hydroxyl compared to hydroxyl groups. So, decrease the scavenger activity of aminated chitosan rather than chitosan itself may be explained on the idea of consumption of hydroxyl group in amination process.…”

Section: Rotational Viscometry Methodsmentioning

confidence: 99%

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Free radical scavenger activity of chitosan and its aminated derivative

Tamer¹,

Valachová²,

Mohyeldin³

et al. 2016

J App Pharm Sci

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Antioxidants may have a positive effect on human health since they can protect the human body against deterioration by reactive oxygen species (ROS). Chitosan has many promising properties as nontoxic, biocompatible, biodegradable, antimicrobial and recently antioxidant properties. Most of the reports on the antioxidant activity of chitosan are based on the ability of amine and hydroxyl group to scavenge free radical to form stable macromolecular radical. In the current study, a new chitosan derivative with extra free amine groups was evaluated using two popular antioxidant evaluation methods (uninhibited/inhibited hyaluronan degradation and decolorization of ABTS method). The result obtained in our study show increase the activity of aminated chitosan for scavenging free radicals than chitosan itself.

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Section: Rotational Viscometry Methodsmentioning

confidence: 99%

“…The most suitable one is the interaction of free radical with hydroxyl or amine group to form stable macromolecule radicals (Xie et al, 2001). …”

Section: Abts Methodsmentioning

confidence: 99%

Free radical scavenger activity of chitosan and its aminated derivative

Tamer¹,

Valachová²,

Mohyeldin³

et al. 2016

J App Pharm Sci

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“…Antimicrobial properties of chitosan and chitosan derivatives have been widely explored (Shahidi et al 1999;Lim and Hudson 2003;Rabea et al 2003). Antioxidant properties of chitosan derivatives have been studied (Lin and Chou 2004;Xie et al 2001;Xing et al 2005). Furthermore, antioxidant properties of fungal chitosan from shiitake stipes have also been studied (Yen et al 2007).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antimicrobial and Antioxidant Activity of Chitosan Isolated from Podophthalmus Vigil

Prabu¹

2012

J. App. Pharm. Sci.

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In the present study, Chitin has been extracted from Podophthalmus vigil. The obtained chitin was transformed into the more useful chitosan we evaluated the antimicrobial activity of different concentrations (25%, 50%, 75% and 100%) of chitosan against 10 species of bacteria and fungi by agar-disc diffusion method. As the concentration of chitosan increased, the antimicrobial effect was strengthened. In the conjugated diene method, the total antioxidant activity of chitosan was ranging from 18.37% to 79.58% at varying concentrations (0.1 to 10mg/ml). The reducing capability ranged from of 0.12% to 0.48% at varying concentration (0.1 to 10mg/ml). The 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging potential of chitosan ranged from 18.08% to 55.56% at varying concentrations (0.1 to 10mg/ml). The chelating ability of chitosan from Podophthalmus vigil on ferrous ions was ranging from 25.82% to 73.54% for the concentration between 0.1-10mg/ml. Hydroxyl radicals scavenging activity of chitosan (0.125-2 mg/ml) was found to be higher than the ascorbic acid and the range was from 23.18% to 93.28%. Superoxide anion radical was ranging from 5.21% to 65.81% for the concentration between 0.125-2 mg/ml. overall, chitosan from Podophthalmus vigil was good in antimicrobial and antioxidant activity, and may be used as a source of antioxidants, as a possible food supplement or ingredient in the pharmaceutical industry. .

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“…Although both plain and derivative chitosans are effective as antimicrobial agents on a wide variety of microorganisms including fungi, algae and some bacteria, these effects vary [4]. Xie et al [24] demonstrated that water-soluble chitosan derivatives had antioxidant activity. The therapeutic ability of NOCC to reduce the formation of post-surgical, pericardial adhesions was also examined in a rabbit model.…”

Section: Discussionmentioning

confidence: 99%

“…Developmental work has produced NOCC gel/Factor IX formulations that persist in vivo for up to 14 days. This combination's second effect was to demonstrate that water-soluble chitosan derivatives had antioxidant activity [24]. NO and its donors such as SPER/NO may have antioxidant effects and enhance other drugs' antioxidant effect [9,16].…”

Section: Discussionmentioning

confidence: 99%

Reduction of Postoperative Adhesions by N,O-Carboxymethylchitosan and Spermine NONOate in Rats.

Duran¹,

Ak²,

Çetin³

et al. 2003

Exp. Anim.

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Abstract:Background: Postsurgical adhesions can occur following virtually all types of surgery, resulting in serious clinical complications. Therefore, prevention of adhesions is an important goal of surgical practice. A rat uterine horn model was used to investigate the efficacy of N,O-carboxymethylchitosan (NOCC) and spermine NONOate (SPER/NO) alone and in combination in preventing adhesion formation. Methods: Sixty Wistar albino rats underwent bilateral uterine horn injury with a unipolar cautery. Study groups were as follows: (i) control group, no adjuvant therapy; and those with adjuvant applied, (ii) normal saline group, 2 ml of normal saline was given; (iii) NOCC group, 2 ml of 2% NOCC gel was given; (iv) SPER/NO group, 2 ml of SPER/NO (0.5 mg/ml) was given, and (v) NOCC plus SPER/NO group, 2 ml of 2% NOCC gel including SPER/NO (0.5 mg/ml) was given. After 14 days, all animals were euthanatized, and a standard adhesion scoring system including extent and severity scores was applied by a blinded examiner. Results: The extent score in NOCC plus SPER/NO group was significantly lower than those of control and normal saline groups (p<0.05). The extent score in NOCC group was significantly lower than that of normal saline group (p<0.05). The extent score in NOCC plus SPER/NO group was significantly lower than that of SPER/NO group (p<0.05). The severity score was significantly lower in NOCC plus SPER/NO and NOCC groups than that of control group (p<0.05). The severity score was significantly lower in NOCC plus SPER/NO group than that of SPER/NO group (p<0.05). Conclusions: Postoperative administration of NOCC gel and SPER/NO alone and especially in combination to the site of peritoneal injury reduces the formation of adhesions in the rat uterine horn model. Key words: N,O-carboxymethylchitosan, postoperative adhesion, spermine NONOate, uterus, rat lem causing infertility, pelvic pain, bowel obstruction and difficulty of reoperative surgery [6,15]. Pelvic adhesions have been implicated in the causation of as many as 15% to 20% of cases of infertility [1].

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Antioxidant activity of water-soluble chitosan derivatives

Cited by 547 publications

References 8 publications

Free radical scavenger activity of chitosan and its aminated derivative

Free radical scavenger activity of chitosan and its aminated derivative

In Vitro Antimicrobial and Antioxidant Activity of Chitosan Isolated from Podophthalmus Vigil

Reduction of Postoperative Adhesions by N,O-Carboxymethylchitosan and Spermine NONOate in Rats.

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