Antioxidant activity of Tunisian<i>Geranium robertianum</i>L. (Geraniaceae)

Jemia, Mariem Ben; Wannes, Wissem Aidi; Ouchikh, Olfa; Bruno, Maurizio; Kchouk, Mohamed Elyes

doi:10.1080/14786419.2013.782492

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…When Milovanovic et al (2007) studied E. telmateia they did not detect quercetin, similarly to us, but identified kaempferol which we did not. Ben Jemia et al (2013), Radulovi c et al (2012) and Proestos et al (2013) studied plants from the Geranium genus and obtained much lower TPC values than ours, 32.24 mg GAE/g dw for G. robertianum methanolic extract, 109.5 mg GAE/g dw for G. macrohrryzym ethanolic extract and 4.0 mg GAE/g dw for G. purpureum methanolic extract respectively. While our plant TPC was higher, its scavenging activity of the DPPH radical was lower, with an average of 205 lg/mL versus 19.98 lg/mL for G. robertianum methanolic extract and approximately 70 lg/mL for G. purpureum aqueous extract (Sohretoglu et al 2011).…”

Section: Antioxidant Activity Phenolic Profile and Trace Elementscontrasting

confidence: 52%

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Nunes

Paśko

Tyszka-Czochara

et al. 2016

Pharmaceutical Biology

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Context: Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. luisieri (Lamiaceae) (LS) are all medicinal. Objective: To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zinc. Material and methods: Aerial part extracts were prepared with water (W), ethanol (E) and an 80% mixture (80EW). Antioxidant activity was measured with TAA, FRAP and RP methods. Phenolics were quantified with a HPLC. Zinc was quantified using voltammetry. Antibacterial activity (after 48 h) was tested using Enterococcus faecalis, Bacillus cereus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes. Antiproliferative activity (after 24 h) was tested using HEP G2 cells and fibroblasts. Results: Solvents influenced results; the best were E and 80EW. GP had the highest antioxidant activity (TAA and FRAP of 536.90 mg AAE/g dw and 783.48 mg TE/g dw, respectively). CM had the highest zinc concentration (37.21 mg/kg) and phenolic variety, with neochlorogenic acid as the most abundant (92.91 mg/100 g dw). LS was rich in rosmarinic acid (301.71 mg/100 g dw). GP and LS inhibited the most microorganisms: B. cereus, E. coli and S. aureus. GP also inhibited E. faecalis. CM had the lowest MIC: 5830 lg/mL. The antibacterial activity is explained by the phenolics present. LS and CM showed the most significant anti-proliferative activity, which is explained by their zinc content. Conclusion: The most promising plants for further studies are CM, LS and GP.ARTICLE HISTORY

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Section: Antioxidant Activity Phenolic Profile and Trace Elementscontrasting

confidence: 52%

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Nunes

Paśko

Tyszka-Czochara

et al. 2016

Pharmaceutical Biology

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“…Although no detailed phytochemical studies have yet been carried out concerning condensed tannins of Geranium species, it is likely that procyanidins are a common type (Harborne and Williams, 2002). To date the only data related to condensed tannins in G. robertianum seems to have been reported by Ben Jemia et al (2013) who determined the proanthocyanidins content in a methanol extract of plants native from Tunisia to be 0.86 mg catechin equivalents/g dry weight. This very low amount of tannins was attributed to the low extractability of methanol.…”

Section: Phytochemical Characterizationmentioning

confidence: 99%

“…Flavonoids constitute the main compounds found in G. robertianum (Table 2) and can be found in relatively high amounts (Igwenyi and Elekwa, 2014;Ben Jemia et al 2013;Neagu et al, 2010a;Paun et al, 2011;Paun et al, 2012;Paun et al, 2014). Within this class of secondary metabolites, flavonols, namely, quercetin and kaempferol, are predominant.…”

Section: Flavonoidsmentioning

confidence: 99%

“…20%, against around 90% by concentrated aqueous and hydroethanolic G. robertianum extracts obtained by membrane processes (Paun et al, 2011;Paun et al, 2012). In a β-carotene/linoleic acid bleaching assay, the inhibition capacity of a methanolic extract of G. robertianum (IC 50 = 6.8 ± 1.32 µg/mL) was found to be stronger than that of BHT (butylated hydroxytoluene) (IC 50 = 85 ± 0.11 µg/mL), an antioxidant food additive (Ben Jemia et al, 2013). The same methanolic extract displayed a reducing power (EC 50 = 20 ± 4.53 µg/mL) higher than that of ascorbic acid (EC 50 = 40 ± 1.31 µg/L).…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Phytochemical composition and biological activities of Geranium robertianum L.: A review

Graça

Ferreira

Santos

2016

Industrial Crops and Products

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After a period of a certain indifference, in which synthetic compounds were favored, the interest in the study of the biological properties of plants and the active principles responsible for their therapeutic properties has been growing remarkably. Geranium robertianum L., commonly known as Herb Robert or Red Robin, is a spontaneous, herbaceous plant that has been used for a long time in folk medicine of several countries and in herbalism's practice for the treatment of a variety of ailments. Herein, we present a comprehensive review on the phytochemical characterization and the biological activities of this species, which, accompanying the remarkable increase of its use in herbal medicine, has been disclosed in the literature mainly in the last decade.The phytochemical characterization of G. robertianum has been focused mostly on the investigation of solid-liquid extracts of the plant, with special emphasis on phenolic compounds, particularly flavonoids. Studies concerning the essential oils of this species are still scarce but the number of identified compounds is high. The chemistry of G. robertianum is clearly dominated by phenolic constituents, the most studied classes of compounds being tannins, flavonoids and phenolic acids.The confirmation of the antioxidant, antimicrobial, anti-inflammatory, anti-hyperglycaemic and 2 cytotoxic activities of G. robertianum, closely related to the high content of phenolic compounds, has come to corroborate in some extent the recognized beneficial proprieties of this medicinal plant.

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“…Because many studies revealed a relationship between phenolic compounds and antioxidant activity (Popa et al, 2012;Jemia et al, 2013), the antioxidant activity was also assessed to determine the possible mechanisms of action.…”

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confidence: 99%

Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.

Sobreira

Hernandes

Vetore-Neto

et al. 2017

Braz. J. Pharm. Sci.

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Peptic ulcers are an important pathology, and the search for safer and more effective treatment methods is of paramount importance. In this study, we assess the gastroprotective effects of the hydroethanolic extract (HE) and ethyl acetate fraction (EAF) from Kalanchoe pinnata leaves against an ethanol/HCl-induced ulcer model in rats. The HE reduced gastric lesions by approximately 47% (400 mg/kg). A significant inhibition of the gastric lesions by 50% was observed after pretreatment with the EAF (200 mg/kg). Quercetrin and quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside were isolated and identified in the flavonoid fraction (EAF) by HPLC and NMR analyses because this fraction showed the highest gastroprotective effect. This fraction demonstrated high antioxidant activities (CE 50 =41.91 µg/mL) by DPPH in comparison with Trolox ® and 11.33 mmol Trolox ® equivalent by ORAC. In conclusion, the HE and FAE from K. pinnata displayed gastroprotective activity in rats, most likely due to the presence of flavonoids.Uniterms: Gastric ulcer/study/rats. Gastric ulcer/treatment. Kalanchoe pinnata/chromatographic profile. Kalanchoe pinnata/gastroprotective activity. Quercetrin. Quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside. INTRODUCTIONFor the past two centuries, peptic ulcers have caused high morbidity and mortality (Malfertheiner, Chan, Mccoll, 2009). This disease is a serious and prevalent pathology (Calam, Baron, 2001). A peptic ulcer is a chronic lesion, usually single, that can be located in the gastric or duodenal mucosae (Kumar, Abbas, Fausto, 2005). In the UK, the incidence of this disease was 12% higher in men than in women (Araujo, Borini, Guimarães, 2014). A review article (January 1980 to February 2009 showed that the incidence rate of uncomplicated peptic ulcers was approximately one case per 1000 people per year in the general population; the incidence rate for complicated peptic ulcers that included bleeding and perforation was approximately 0.7 cases per 1000 people per year (Lin, Rodrígues, Hernándes-Diaz, 2011).The pathophysiology of peptic ulcers suggests that this disease is caused by an imbalance between defensive factors (mucus and bicarbonate secretion, mucosal barrier, blood flow, and prostaglandins) and destructive factors (reactive oxygen species and acid and pepsin secretion), resulting in the acute inflammation of the gastrointestinal mucosae (Laine, Takeuchi, Tarnawski, 2008). Several stimuli serve as offensive factors, including Helicobacter pylori, the use of nonsteroidal anti-inflammatory drugs (NSAIDs), stress, alcohol and cigarette smoking (Malfertheiner, Chan, Mccoll, 2009;Malnick et al., 2014). The current medical treatment for peptic ulcers is generally based on proton pump inhibitors and histamine H 2 -receptor blockers (Jain et al., 2007). However, the long-term use of these therapeutic agents can produce adverse effects, such as hypergastrinemia and hyperplasia in the enterochromaffinlike (ECL) cells, the risk of pneumonia, diarrhea and the disturbance of ...

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Antioxidant activity of TunisianGeranium robertianumL. (Geraniaceae)

Cited by 9 publications

References 28 publications

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Phytochemical composition and biological activities of Geranium robertianum L.: A review

Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.

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