Antioxidant Activity of Traditional Siddha Formulation on Ccl4 Induced Liver Fibrosis in Rats

Diwakar, Manickam; Ramamoorthy, Sri Kamatchi Priya; Udhayakumar, Mythily; Kumar, B. Santhosh

doi:10.22159/ijpps.2017v9i10.20619

Cited by 2 publications

(2 citation statements)

References 41 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Manickam et al also observed a similar type of result in CCL 4 -treated rats, and they recommend due to injury in liver damage. CAT and GPx are very important enzyme defense against dangerous reactive oxidizing molecules converted to H 2 O, thereby providing protection to the cells from FR, and also GPx reduces the lipid hydroperoxide and H 2 O 2 nontoxic product [42]. During the stressful condition, CAT enzyme plays an important role to reduce the H 2 O 2 produced from the metabolism of long chain fatty acids in peroxisomes.…”

Section: Manju and Jagadeesanmentioning

confidence: 99%

In Vivo Hepatoprotective Effect of Caffeic Acid on Mercuric Chloride-Induced Biochemical Changes in Albino Wistar Rats

Manju

Jagaseesan

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Mercury (Hg) is a highly dangerous and also one of the harmful heavy metals which induces oxidative stress in the animal body. The present study is planned to examine the possible defensive result of caffeic acid (CA) against mercury chloride (HgCl2)-induced hepatotoxicity in male albino Wistar rats, Rattus norvegicus. Methods: Sublethal dose of HgCl2 (1.29 mg/kg body weight) was administrated in rats for 15 days through oral dose and the CA was administrated for another 15 days on mercuric-intoxicated rats. After completing the scheduled exposure time, the rats were sacrificed and the whole liver organ was removed immediately from the animal, and it was used to carry out for biochemical and bioenzymological studies to observe. Results: The level of lipid peroxidation (LPO) content reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the liver tissue. CA is an energetic component in the phenolic propolis extract and also in a wide variety of plants, and a strong antioxidant helps to prevent oxidative damage and to reduce oxidative stress. The antioxidants such as GPx, CAT, and SOD and non-antioxidant GSH were significantly decreased, and also, the LPO level was increased in mercury toxicity rats. The treatment of CA (5 mg/kg body weight) in the liver tissue shows considerable declining in the level of oxidant content and along with an increase in the level of antioxidant properties by the way of improvement in liver tissues. Antioxidant and non-antioxidant enzyme (LOP, GSH, GPx, SOD, and CAT) activities were also significantly decreased to near untreated control level when compared to Hg-treated group. The CA acid alone treatment showed the enhanced antioxidant levels and not any alteration in the levels of biochemical parameters when compared with control. Conclusion: These observations of the present experimental study clearly explained the detoxify effects and protective effect of CA against HgCl2 toxicity in liver tissue.

show abstract

Section: Manju and Jagadeesanmentioning

confidence: 99%

In Vivo Hepatoprotective Effect of Caffeic Acid on Mercuric Chloride-Induced Biochemical Changes in Albino Wistar Rats

Manju

Jagaseesan

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…As the traditional and ethnic being tested for their efficacy, new formulations of hepatoprotective drugs have also been tested in rats [1]. Our laboratory is also engaged in testing bhasmas for their efficacies and probable mode of action against induced hepatotoxicity [2,3].…”

Section: Introductionmentioning

confidence: 99%

ABHRAK BHASMA AND SiO2 INFLUENCED FREE RADICAL STATUS IN LIVER AND KIDNEY OF CCl4-INDUCED ACUTELY INTOXICATED MALE ALBINO RAT

TELI¹,

KANASE²

2020

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The objective of the study was to study the mechanism of action of abhrak bhasma-mediated liver and kidney protection in CCl4-induced acute hepatotoxicity-induced male albino rats. Action of abhrak bhasma is compared with the action of SiO2 in similar experimental conditions to differentiate the role of silicon. Methods: Male albino rats (Rattus norvegicus) were used for experiments. The acute hepatotoxicity was induced by daily dose of CCl4 (3.0 ml/kg body wt for 7 days consecutive). Concurrent treatment of abhrak bhasma in graded doses (10, 20, 30, and 40 mg) was given for 7 days (PO). SiO2 (10, 20, 30, and 40 mg) in graded doses was also given in independent groups of rats as silica control. Lipid peroxidation (LPO) in liver and kidney was studied by malondialdehyde (MDA) estimations as parameter of toxicity and also to study protection. Results: CCl4-induced hepatotoxicity (MDA levels) is partially managed by low doses of SiO2 but not by high doses. Abhrak bhasma hepatoprotective activities were dose dependent. A 40 mg dose maintained normal levels of LPO. Abhrak bhasma also protected associated renal toxicity. Conclusion: Abhrak bhasma protected CCl4-induced hepatotoxicity and also associated renal toxicity. Silicon from both SiO2 and abhrak bhasma is hepatoprotective in 10 ml doses (10 and 20 mg) but silicon processed in abhrak bhasma by traditional Ayurvedic processes increased its potency and hepatoprotection and added the potency of renal protection.

show abstract

Antioxidant Activity of Traditional Siddha Formulation on Ccl4 Induced Liver Fibrosis in Rats

Cited by 2 publications

References 41 publications

In Vivo Hepatoprotective Effect of Caffeic Acid on Mercuric Chloride-Induced Biochemical Changes in Albino Wistar Rats

In Vivo Hepatoprotective Effect of Caffeic Acid on Mercuric Chloride-Induced Biochemical Changes in Albino Wistar Rats

ABHRAK BHASMA AND SiO2 INFLUENCED FREE RADICAL STATUS IN LIVER AND KIDNEY OF CCl4-INDUCED ACUTELY INTOXICATED MALE ALBINO RAT

Contact Info

Product

Resources

About