Antioxidant activity of Thespesia populnea bark extracts against carbon tetrachloride-induced liver injury in rats

Ilavarasan, R.; Mani, Vasudevan; Anbazhagan, S.; Venkataraman, S.

doi:10.1016/s0378-8741(03)00147-8

Cited by 73 publications

(55 citation statements)

References 8 publications

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“…Thespesia populnea has been reported to possess antioxidant property as well (Ilavarasan et al, 2003a). The neuroprotective effect of TPE may be attributed to its (TPE 100,200,and 400 mg=kg,p.o.…”

Section: Discussionmentioning

confidence: 99%

“…The fruits of the plant are used in Ayurveda for the control of diabetes (Sathyanarayana et al, 2004). The barks and flowers possess astringent, hepatoprotective, and antioxidant activity in rats (Shirwaikar et al, 1995;Ilavarasan et al, 2003aIlavarasan et al, , 2003b. Immunohistochemical studies revealed the existence of chronic inflammation in certain regions of the brain in Alzheimer disease patients.…”

Section: Introductionmentioning

confidence: 99%

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Memory-Enhancing Activity ofThespesia populnea. in Rats

Mani

Parle

2007

Pharmaceutical Biology

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Thespesia populnea Soland ex. Correa (Malvaceae) is a large tree found in the tropical regions and coastal forests of India. Various parts of Thespesia populnea are found to possess useful medicinal properties such as antifertility, antibacterial, anti-inflammatory, antioxidant, purgative, and hepatoprotective activities. The current study was undertaken to investigate the effects of Thespesia populnea bark on memory in rats. Elevated plus-maze and Hebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-, and ageing-induced amnesia served as the interoceptive behavioral models. The ethanol extract of Thespesia populnea (TPE) was administered orally in three doses (100, 200, and 400 mg=kg) for 7 successive days to different groups of young and aged rats. TPE (200 and 400 mg=kg, p.o.) resulted in significant improvement in memory of young and aged rats. TPE also reversed the amnesia induced by scopolamine (0.4 mg=kg, i.p.) and diazepam (1 mg=kg, i.p.). Cholesterol-lowering, anticholinesterase, anti-inflammatory, and antioxidant properties of Thespesia populnea may favorably contribute to its memory-enhancement effect. Therefore, Thespesia populnea bark appears to be a promising candidate for improving memory, and it would be worthwhile to explore the potential of this plant in the management of Alzheimer patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Memory-Enhancing Activity ofThespesia populnea. in Rats

Mani

Parle

2007

Pharmaceutical Biology

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“…An ayurvedic preparation contains Thespesia populnea, namely "panchvalkala" posses' free radical scavenging activity [17]. The barks and flowers posses astringent, hepatoprotective, antioxidant and anti-inflammatory activities in rats [18], [19], [20], [21] and also supposed to improve the memory [22].…”

Section: Introduction:-mentioning

confidence: 99%

“…It produces greyish green or black seeds encased in tear-dropped shaped grey or black shells that often times featured black and white strips. Seeds encased in plant contains monoterpenes (α-pinene, Sabinene) [16][17], diterpenes (Helikauranoside) [18], oleic acid, triacyl glycerol, alkaloids, cyanogenic glycosides, saponins, cardiac glycosides, tannins, fixed oils, flavanoids [19], sesquiterpenes lactones [18] and alkaloids [20]. Flowers contain quercimeritrin, anthocyanin, abundant amount of cholin and betain, triterpene [21] and saponins [22].…”

Section: Introduction:-mentioning

confidence: 99%

Antidiabetic Effect of Some Medicinal Plants Bark, Leaf and Seed Extracts in Streptozotocin Induced Diabetic Rats.

Razak¹,

Elyas²,

Thomas³

et al. 2016

IJAR

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“…The alcoholic extract of unripe fruits reported for the antibacterial activity (Gaind and Bapna, 1967), anti-hyperglycemic (Satyanarayana et al, 2004), and wound healing potential (Nagappa and Binu, 2001). The bark has been reported for anti-oxidant activity (Ilavarasan et al, 2003), antinociceptive and anti-inflammatory activity (Vasudevan and Parle, 2006), alzheimers disease (Vasudevan et al, 2007), and antidiarrheal activity (Viswanatha et al, 2007). The bark contains thespesone, which is having 2-hydroxy-2, 4, pyranonaphtaquinone as a parent nucleus.…”

Section: Introductionmentioning

confidence: 99%

Effect of Thespesia populnea Linn. on dexamethasone induced insulin resistance in mice

Phanse¹,

Patil²,

Abbulu³

2014

Afr. J. Pharm. Pharmacol.

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In traditional medicine, plants have been used to treat diabetes mellitus as valuable alternative therapy since synthetic oral hypoglycemic agents are known to exhibit adverse side effects. The present study was planned to investigate the effect of ethanolic extract of bark of Thespesia populnea Linn (TP) on plasma glucose, serum triglyceride and body weight in dexamethasone-induced insulin resistance in mice. The animals were divided into diabetic and non-diabetic groups consisting of six animals in each group. TP was administered at doses of 100, 200, and 400 mg/kg per oral (p.o.) in mice which were concomitantly treated with pre-standardized dose of dexamethasone (1 mg/kg intramuscular (i.m.)) for 22 days and effect on plasma glucose, serum triglyceride level and change in body weight were recorded. TP showed significant decrease in plasma glucose (p<0.01), serum triglyceride (p<0.01) levels and significant increase in body weight (p<0.01) as compared to dexamethasone control group. This study revealed that the ethanolic extract of bark of T. populnea may prove to be effective in the treatment of insulin resistance owing to its ability to decrease peripheral insulin resistance and can be used in the treatment of type-II diabetes mellitus.

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Antioxidant activity of Thespesia populnea bark extracts against carbon tetrachloride-induced liver injury in rats

Cited by 73 publications

References 8 publications

Memory-Enhancing Activity ofThespesia populnea. in Rats

Memory-Enhancing Activity ofThespesia populnea. in Rats

Antidiabetic Effect of Some Medicinal Plants Bark, Leaf and Seed Extracts in Streptozotocin Induced Diabetic Rats.

Effect of Thespesia populnea Linn. on dexamethasone induced insulin resistance in mice

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