Antioxidant activity of some lichen metabolites

Thadhani, Vinitha M.; Choudhary, M. Iqbal; Ali, Sajjad; Omar, Iman; Siddique, Hina; Karunaratne, Veranja

doi:10.1080/14786419.2010.529546

Cited by 98 publications

(101 citation statements)

References 32 publications

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“…Arg. ), Motyka (Parmeliaceae) (Behera et al, 2012), Usnea ghattensis (Verma et al, 2008b), psoromic and usnic acids (Behera et al, 2012), and on other 14 lichenpurified metabolites (Thadhani et al, 2011). Moreover, hydrogen peroxide scavenging activity was investigated on Parmelia saxatilis (Ö zen & Kinalioglu, 2008) and the TEAC value (Trolox equivalent antioxidant capacity) has been determined using the ABTS radical assay in several polar lichen species Singh et al, 2011), as well as in Usnea ghattensis (Behera et al, 2005a;Verma et al, 2008a), Laurera benguelensis Zahlbr.…”

Section: Antioxidant Properties Of Lichensmentioning

confidence: 99%

Antioxidant potential of lichen species and their secondary metabolites. A systematic review

Fernández-Moriano¹,

Gómez-Serranillos²,

Crespo

2015

Pharmaceutical Biology

108

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Context: Pharmacological interest of lichens lies in their capacity to produce bioactive secondary metabolites, being most of them phenolic compounds with reactive hydroxyl groups that confer antioxidant potential through various mechanisms. Increasing incidence and impact of oxidative stress-related diseases (i.e., neurodegenerative disorders) has encouraged the search of new pharmacological strategies to face them. Lichens appear to be a promising source of phenolic compounds in the discovery of natural products exerting antioxidant activity.Objective: The present review thoroughly discusses the available knowledge on antioxidant properties of lichens, including both in vitro and in vivo studies and the parameters assessed so far on lichen constituents. Methods: Literature survey was performed by using as main databases PubMed, Google Scholar, Scopus, Science Direct, and Recent Literature on Lichens. We reviewed 98 highlighted research articles without date restriction. Results: Current report collects data related to antioxidant activities of more than 75 lichen species (from 18 botanical families) and 65 isolated metabolites. Much information comes from in vitro investigations, such as chemical assays evaluating radical scavenging properties, lipid peroxidation inhibition, and reducing power of lichen species and compounds; similarly, research on cellular substrates and animal models generally measures antioxidant enzymes levels and other antioxidant markers, such as glutathione levels or tissue peroxidation. Conclusion: Since consistent evidence demonstrated the contribution of oxidative stress on the development and progression of several human diseases, reviewed data suggest that some lichen compounds are worthy of further investigation and better understanding of their antioxidant and neuroprotective potentials.

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Section: Antioxidant Properties Of Lichensmentioning

confidence: 99%

Antioxidant potential of lichen species and their secondary metabolites. A systematic review

Fernández-Moriano¹,

Gómez-Serranillos²,

Crespo

2015

Pharmaceutical Biology

108

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“…Usnic acid, salazinic acid, and atranorin are the major compounds reported in this study which have several important biological roles. These compounds have strong antimicrobial property [30][31][32], anticancerous properties [33], antiherbivorous [34],; antioxidants [35,36], and immunomodulatory [37]. Almost all the metabolites identified in the TLC results of this study have also been reported as sources of commercial dyes [38].…”

Section: Ramya and Thirunalasundarimentioning

confidence: 69%

A Study on Epiphytic Lichens From Prunus Persica

Ramya

Thirunalasundari

2018

Asian J Pharm Clin Res

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Objective: The objective of this study is to explore and identify the epiphytic lichens on the tree bark of Prunus persica from Kodaikanal area and analyze its phytochemical properties.Methods: Samples were collected from Kodaikanal area, identified by morphological and chemical constituents. Macromolecules present were quantified by DNS method, Lowry's method, and lipid tests. The secondary metabolites present were analyzed by standard phytochemical tests and thin-layer chromatography. Results and Conclusion:It was interesting to observe that species belonging to the lichen genera -Parmotrema, Ramalina, and Usnea dominated the area. The samples have been identified and deposited in LWG herbarium, NBRI, Lucknow. As lichens form an ideal model to study the humongous secondary metabolites present in it, a preliminary investigation was performed to understand the nutritive value as well as phytochemicals present in the lichens. The results indicate that these organisms can be of potential medicinal value with Ramalina and Usnea species contributing good amount of macronutrients present in them, while qualitative analysis of phytochemicals reports all the lichens for enormous metabolites.

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“…A remarkable feature of lichen species is their antioxidant capacity that resides in their phenolic moieties [31]. Interestingly, some depsides and depsidones isolated from lichens have shown antioxidant capacity [32][33][34]. Besides this, neuroprotective effect and cytotoxic potential have been described in Cetraria islandica and Vulpicida canadensis [35].…”

Section: Lichens As Antioxidants and Tau Inhibitors Sourcementioning

confidence: 99%

Secondary Metabolites of Lichens as Both Anti-aggregative and Antioxidant Agents in Tauopathies

Cornejo¹,

Areche²

2017

J Clin Cell Immunol

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This commentary described our findings of parietin, an anthraquinone, isolated from Ramalina terebrata as inhibitor of tau protein. Moreover, we considered important to link tauopathies with reactive oxygen species since oligomers and fibril-forming elements are responsible for activating reactive oxygen species, which cause inflammatory response and neurodegeneration. Together, we considered important to find naturally occurring compounds that might be able to stop aggregation and reduce ROS cells damage.Keywords: Tauopathies; Secondary metabolites; Lichens; Reactive oxygen species; Inflammatory response; Neurodegeneration Tauopathies and NeurotoxicityTaoupathies are neurodegenerative disorders involving tau protein, such as progressive nuclear palsy (PSP), corticobasal degeneration (CBD), Pick´s disease among others. Tau is an unfolded protein which is found mainly in axons of mature and physiologically is involved in microtubule stability and axonal transport [1]. However, once tau becomes hyperphosphorylated it detaches from microtubule starting the aggregation process [2,3]. Pathological tau aggregates are able to activate glia cells that release cytotoxic factors, which cause pro inflammatory cytokines such as TNF-α, IL-1 and IL-6 and chemokines [4]. Tau phosphorylation is increased in both physiologically and pathological state [5], however phosphorylation is increased during development, suggesting that process is needed for neuronal plasticity [6]. Tau phosphorylation is an event highly regulated by kinases and phosphatases. Its balance is deregulated due to several stimuli such as oxidative stress [7]. Tau is able to form paired helical filaments closely related to neurofibrillary tangles [8,9]. Hyperphosphorylated tau protein is found in patients suffering with tauopathies in cerebrospinal fluid (CNS), which correlates well with hypocampal atrophy [10]. In addition, tauopathies have tau hyperphosphorylated as a hallmark; however, the degree of phosphorylation differs among them. In addition, it is important to notice that there is no single phosphorylation site associated to a particular tauopathy [5]. Moreover, tau has the propensity to form aggregates, since inside the full length protein (441 aminoacids) resides a region known as 4R (four microtubule binding domain) containing two hexapeptides 275 VQIINK 280 and 306 VQIVYK 311 both associated to β sheet formation [11]. Increased tau phosphorylation decreased its binding for microtubules. These species prone to form aggregates which are toxic in both cell and transgenic mouse model [12,13]. Despite that fact, there are evidences showing that soluble species and pre fibrils which are more related to toxicity [14]. An interesting UV raman spectroscopy study showed that at early stages, within the first hour, fibrillar aggregates possess a mixture of β-sheet and disordered content. Afterward, the UVRR spectra shows a consolidation in fibril structure, augmenting the content of β sheet [15], interesting is to remark that toxicity apparently reli...

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Antioxidant activity of some lichen metabolites

Cited by 98 publications

References 32 publications

Antioxidant potential of lichen species and their secondary metabolites. A systematic review

Antioxidant potential of lichen species and their secondary metabolites. A systematic review

A Study on Epiphytic Lichens From Prunus Persica

Secondary Metabolites of Lichens as Both Anti-aggregative and Antioxidant Agents in Tauopathies

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