Antioxidant Activity of Saliva and Periodontal Disease

Moore, Suzanne; Calder, Karen A.C.; Miller, Nicholas J.; Rice‐Evans, Catherine

doi:10.3109/10715769409056594

Cited by 225 publications

(208 citation statements)

References 15 publications

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“…Salivary AD concentrations (umol/L Trolox) and saliva: serum AD ratios were lower in adult patients with periodontitis than those without the disease. These data do not agree with those of Moore et al, 17 who found no differences between salivary AD capacities (concentrations or total capacity) in periodontal health or disease. The reason for the discrepancy could be due to the different assay methods employed, the mode of saliva stimulation and storage, or the classification of patient groups by disease status.…”

Section: Discussioncontrasting

confidence: 56%

Enhanced Chemiluminescent Assay for Measuring the Total Antioxidant Capacity of Serum, Saliva and Crevicular Fluid

et al. 1997

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SUMMARY. This paper reports the development of an enhanced chemiluminescent (ECL) assay for measuring the total antioxidant (AO) capacity of serum, saliva and a fluid collectable from the gum margin called gingival crevicular fluid (GCF). The theory behind the assay is explained, and the optimum conditions for the assay, and for storage of reagents and clinical samples is described. Calibration lines were linear (R~0'99; P

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Section: Discussioncontrasting

confidence: 56%

Enhanced Chemiluminescent Assay for Measuring the Total Antioxidant Capacity of Serum, Saliva and Crevicular Fluid

et al. 1997

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“…It has been suggested that saliva is rich in antioxidant, mainly uric acid with lesser but definite contributions from albumin, ascorbate and glutathione and all of these are proteins or have proteins in their structure. It has been reported that uric acid is the major antioxidant in saliva accounting for more than 85% of total antioxidant capacity of both unstimulated and stimulated saliva [15] thus it can be concluded that salivary antioxidant levels must be in a linear association with total protein levels.Our results were in sync with a related study conducted by Tulunoglu which also reported that total antioxidant capacity of saliva increased with caries activity [16]. In our study total antioxidant capacity is decreased in caries free children.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Flow Rate, pH, Buffering Capacity, Calcium, Total Proteins and Total Antioxidant Capacity Levels of Saliva in Caries Free and Caries Active Children: An In Vivo Study

Preethi¹,

Dodawad

Anand³

2010

Ind J Clin Biochem

105

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The purpose of this study was to evaluate the relationship between the physicochemical properties of saliva such as flow rate, pH, buffering capacity, calcium level, total protein and total antioxidant levels in caries free and caries active children. The present study included one hundred and twenty healthy children who were divided into two groups; group I and group II comprising of age groups 7-10 and 11-14 years, respectively. Both the groups were then sub-divided equally according to gender. They were further divided into caries free and caries active with 15 children in each group. Unstimulated saliva was collected by suction method and flow rates were determined. The samples were then analyzed for pH, buffering capacity, total protein, calcium and total antioxidant capacity. The data was statistically analyzed using student t test (unpaired). The results revealed that when all these parameters were compared among the caries free and caries active children, flow rate, pH, buffering capacity were slightly reduced in caries active children, but total protein and total antioxidant capacity of saliva increased significantly in caries active children and the total calcium decreased significantly in caries active children. Within the limitation of this study, we conclude that, the physicochemical properties of saliva play a major role in the development of caries.

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“…Hoek et al has reported increased albumin levels even more than 45 minutes after toothbrushing [19]. Albumin is an important salivary antioxidant [33] and may therefore represent another factor contributing to increased total antioxidant capacity after tooth-brushing.…”

Section: Effect Of Tooth-brushingmentioning

confidence: 99%

Salivary Markers of Oxidative Stress and Antioxidant Status: Influence of External Factors

2013

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Abstract.BACKGROUND: Salivary markers of oxidative stress and antioxidant status represent promising tool for the research of oral diseases. One of the criteria is the validation of these biomarkers from the perspective of the confounding and modifying factors. AIM: To examine the effect of circadian rhythm, tooth-brushing and ascorbic acid treatment on selected salivary markers of oxidative and carbonyl stress, and antioxidant status. SUBJECTS AND METHODS: Whole unstimulated saliva samples were collected from 19 healthy participants three times during a day, before and after tooth-brushing, and before and after the administration of vitamin C (250 mg). Advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances (TBARS), advanced glycation end products (AGEs), ferric reducing antioxidant power (FRAP) and total antioxidant capacity (TAC) were measured. RESULTS: Salivary AGEs levels varied significantly during the day (p < 0.05) with the highest concentrations in the morning. FRAP levels varied during the day (p < 0.01) with the highest concentrations in the afternoon. Tooth-brushing decreased AGEs (p < 0.05) and TBARS levels (p < 0.01) and increased FRAP levels (p < 0.05). Single intake of vitamin C significantly decreased AGEs (p < 0.001) and increased both FRAP (p < 0.01) and TAC (p < 0.01) concentrations. CONCLUSION: Significant daily variations were observed in salivary AGEs and FRAP levels. Tooth-brushing and treatment with vitamin C decreased carbonyl stress and increased the antioxidant status. These results are important from the perspective of using saliva for the research of oral diseases.

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Antioxidant Activity of Saliva and Periodontal Disease

Cited by 225 publications

References 15 publications

Enhanced Chemiluminescent Assay for Measuring the Total Antioxidant Capacity of Serum, Saliva and Crevicular Fluid

Enhanced Chemiluminescent Assay for Measuring the Total Antioxidant Capacity of Serum, Saliva and Crevicular Fluid

Evaluation of Flow Rate, pH, Buffering Capacity, Calcium, Total Proteins and Total Antioxidant Capacity Levels of Saliva in Caries Free and Caries Active Children: An In Vivo Study

Salivary Markers of Oxidative Stress and Antioxidant Status: Influence of External Factors

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