Antioxidant Activity of Quercetin-Containing Liposomes-in-Gel and Its Effect on Prevention and Treatment of Cutaneous Eczema

Abstract

Cutaneous eczema is a kind of skin disease is characterized by inflammation. The main manifestations are various types of dermatitis, eczema, and urticaria. There are usually complications such as erythema, blisters, and epidermal peeling. The quercetin might have a therapeutic effect on cutaneous eczema due to its favorable antioxidant activity and anti-inflammatory effects. Currently, there are few studies on transdermal administration of antioxidant drugs for the treatment of cutaneous eczema. The aim of this study was to prepare quercetin-containing liposomes-in-gel (QU-LG), its antioxidant properties were evaluated, and it was used in the skin of mice suffering from dermal eczema to see if it had preventive and therapeutic effects in an attempt to make it a new option for the treatment of cutaneous eczema. QU-LG was prepared by the injection method to form the quercetin-containing liposomes (QU-L) and evenly dispersed in the natural dissolution of carboxymethylcellulose sodium (1%, CMC-Na). The release of QU-LG across the dialysis membranes was up to 30% and clearance of 1,1-diphenyl-2-picrylhydrazyl (DPPH) was 65.16 ± 3.513%. In anti-oxidation assay QU-LG inhibited malondialdehyde (MDA) production in liver better than the commercially available drug dexamethasone acetate cream. Compared with untreated mice, mice treated with QU-LG showed a statistically significant reduction in dermatopathologic symptoms. The results suggested that QU-LG had good antioxidant activity in vivo and in vitro and could be used for the prevention and treatment of cutaneous eczema.

Characterization Methods for Nanoparticle–Skin Interactions: An Overview

“…Table 1 delineates various prevalent drug nanocarriers, encompassing polymeric NPs, lipid NPs (such as liposomes, ethosomes, SLNs, and nanostructured lipid carriers), nanoemulsions, dendrimers, micelles, and inorganic NPs tailored for transdermal delivery. [18][19][20] Acne, psoriasis, ichthyosis [21][22][23] Anti-inflammatory [24,25] Nanostructured lipid carriers Yes No 50-500 Anti-inflammatory (Immuno-suppressive) [26] Local analgesic, anti-inflammatory [27,28] Antimicrobial [29] Anticancer [30] Nanoemulsions Yes No 10-1000 Cosmetic use: antioxidant, sunscreens, lipid carriers [31][32][33] Nonsteroidal anti-inflammatory drug carriers [34,35] Anticancer [36,37] Antimicrobial [38] Liposomes No Yes 100-200 Antimicrobial treatment [39,40] Eczema, psoriasis [41,42] Anti-inflammatory [43,44] Skin cancer [45,46] Local anesthesia [47,48] Ethosomes No Yes 100-200 Skin pathology [43,49] Skin cancer [50,51] Skin infections [52,53] Anti-inflammatory and analgesic [54,55] Micelles In the category of NPs, polymeric nanocapsules and nanospheres represent promising tools to increase the cutaneous permeation of pharmaceuticals and bioactive agents. Nanocapsules, characteri...…”