Antioxidant activity of polyphenols and polyphenol complex from the far-eastern tree Maackia amurensis

Utkina, N. K.; Кулеш, Н. И.

doi:10.1007/s11094-012-0831-z

Cited by 15 publications

(17 citation statements)

References 18 publications

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“…25 Its ability to deactivate radical species has been studied. 19 The purity of the retusin isolate was assessed by means of liquid chromatography (LC) electrospray ionization mass spectrometry. The total content of impurities in the retusin isolate was estimated to be about 7% by the peak area normalization method using highperformance LC-UV (detection at 280 nm).…”

Section: Retusin Extractionmentioning

confidence: 99%

“…18 The molecule has a catechol motif in the ring A (see Chart 1) and has been found to possess the highest antioxidant activity in a series of ten isoflavones. 19 Additionally, it was recently shown 20 that a catechol motif containing a molecule of 6,7-dihydroxy-4-methoxyisoflavone, also known as texasin, can selectively inhibit human leukocyte 5-lipoxygenase.…”

Section: Introductionmentioning

confidence: 99%

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Low-energy electron interaction with retusin extracted from Maackia amurensis: towards a molecular mechanism of the biological activity of flavonoids

Pshenichnyuk

Elkin

Кулеш

et al. 2015

Phys. Chem. Chem. Phys.

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The antioxidant isoflavone retusin efficiently attaches low-energy electrons in vacuo, generating fragment species via dissociative electron attachment (DEA), as has been shown by DEA spectroscopy. According to in silico results obtained by means of density functional theory, retusin is able to attach solvated electrons and could be decomposed under reductive conditions in vivo, for instance, near the mitochondrial electron transport chain, analogous to gas-phase DEA. The most intense decay channels of retusin temporary negative ions were found to be associated with the elimination of H atoms and H2 molecules. Doubly dehydrogenated fragment anions were predicted to possess a quinone structure. It is thought that molecular hydrogen, known for its selective antioxidant properties, can be efficiently generated via electron attachment to retusin in mitochondria and may be responsible for its antioxidant activity. The second abundant species, i.e., quinone bearing an excess negative charge, can serve as an electron carrier and can return the captured electron back to the respiration cycle. The number of OH substituents and their relative positions are crucial for the present molecular mechanism, which can explain the radical scavenging activity of polyphenolic compounds.

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Section: Retusin Extractionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low-energy electron interaction with retusin extracted from Maackia amurensis: towards a molecular mechanism of the biological activity of flavonoids

Pshenichnyuk

Elkin

Кулеш

et al. 2015

Phys. Chem. Chem. Phys.

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“…Therefore, we examined these activities in unique isoflavones 1-4 prepared from the tuber of Apios. Although the estrogenic and antioxidant activities of 2 19,20) and 3 21,22) have been reported previously, all other activities demonstrated in this study were reported for the first time.…”

Section: Discussionmentioning

confidence: 41%

Biological activities of unique isoflavones prepared from Apios americana Medik

Kaneta

Koda

Saito

et al. 2016

Bioscience, Biotechnology, and Biochemistry

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Four unique isoflavone aglycones (barpisoflavone A (1), 2'-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activities, estrogen agonistic activities, antioxidant activities, and α-glucosidase inhibitory activities of 1-4. The results obtained showed that 2 possessed potent and 1, 3, and 4 possessed moderate estrogen partial agonistic activities, 1 and 2 possessed moderate antioxidant activities, and 2 and 3 possessed moderate α-glucosidase inhibitory activities.

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“…Since compounds 1 and 2 have no free OH group in their aglycone parts, the lack of antioxidant properties is not surprising. Similarly, the aglycone of compounds 3 and 4 , α ,2′,4,4′‐tetrahydroxydihydrochalcone, is a poor DPPH ∙ scavenger, so the low antiradical activity of its glucoside derivatives should also be expected .…”

Section: Resultsmentioning

confidence: 99%

New Phenolic Compounds from the Roots of Lentil (Lens culinaris)

Żuchowski

Pecio

Reszczyńska

et al. 2016

Helvetica Chimica Acta

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While lentil (Lens culinaris) seeds are phytochemically well characterized, very little is known about secondary metabolites from lentil roots. Our research on lentil roots led to isolation of five phenolic compounds and five group B soyasaponins. Their structures were established using NMR spectroscopy and mass spectrometry. Four phenolics have not been hitherto described in the literature: 4‐O‐β‐d‐glucopyranosyl‐2‐methoxybenzoic acid, (αS)‐4,4′‐di‐O‐β‐d‐glucopyranosyl‐α,2′‐dihydroxydihydrochalcone, (αS)‐4′‐O‐β‐d‐glucopyranosyl‐α,2′,4‐trihydroxydihydrochalcone, and keto‐2‐hydroxyglycitein. The DPPH∙ radical‐scavenging activity of the purified phenolic compounds was additionally evaluated.

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Antioxidant activity of polyphenols and polyphenol complex from the far-eastern tree Maackia amurensis

Cited by 15 publications

References 18 publications

Low-energy electron interaction with retusin extracted from Maackia amurensis: towards a molecular mechanism of the biological activity of flavonoids

Low-energy electron interaction with retusin extracted from Maackia amurensis: towards a molecular mechanism of the biological activity of flavonoids

Biological activities of unique isoflavones prepared from Apios americana Medik

New Phenolic Compounds from the Roots of Lentil (Lens culinaris)

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