Antioxidant activity of Phyllanthus niruri L. herbs: in vitro and in vivo models and isolation of active compound

Da'i, Muhammad; Wahyuni, Arifah Sri; Dk, Ika Trisharyanti; Azizah, Tanti; Suhendi, Andi; Saifudin, Azis

doi:10.5455/njppp.2015.5.0510201575

Cited by 7 publications

(8 citation statements)

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“…species. The ethanolic extract of P. niruri contained a total of 81.59 ± 2.85 mg phenolic equivalent to gallic acid/g extract (Da'i et al, 2016). The study of E. hirta leaf extract showed that the ethanolic extract contained a higher level of phenolic compounds (291.74±2.46 mg gallic acid equivalent/g extract) and flavonoids (40.32±1.67 mg quercetin equivalent/g extract) compared to methanol and water extracts (Asha et al, 2016).…”

Section: Bmentioning

confidence: 96%

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The Combination of Phyllanthus niruri, Euphorbia hirta, and Loranthus sp. as a Source of Antioxidant Agents

Kristiani

Kasmiyati

2021

J Bio Bio Edu

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Meniran (Phyllanthus niruri), patikan kebo (Euphorbia hirta), and benalu (Loranthus sp.) have often been used by people as medicinal plants. This research aimed to measure the levels of flavonoids, phenolics, and ascorbic acid compounds, as well as the Free Radical Scavenging (FRS) activity of ethyl acetate extract from the mixture of P. niruri, E. hirta, and Loranthus sp. The FRS activity was measured with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The level of compounds was measured by using the spectrophotometry method with specific reagents. The result of the FRS activity in ethyl acetate extract from the mixture of P. niruri, E. hirta, and Loranthus sp. varied depending on its dose. The measure of FRS in the P. niruri: E. hirta: Loranthus sp 0:0:1 (K-OOL) composition showed a strong result with a value of IC50 97.2 ± 2.1 ppm, while in the 0:0.5:0.5 (K-OEL) composition it was moderate with a value of IC50 147.6 ± 6.5 ppm. The other compositions showed weak and inactive results. The K-OOL composition had the highest flavonoid and phenolic content that were 298.8±0.00 mg QE/g extract and 141.5±2.85 mg GAE/g extract respectively. The composition with the highest ascorbic acid content (298.8±0.00 mg/g extract) was K-OEO composition. So far, research on medicinal plants is still limited to one type of plant. The combination of several types of plants in several formulations allows obtaining a composition that can produce maximum antioxidant capacity. Therefore, this research is expected to produce a combination formulation of various types of medicinal plants that have the K-OOL composition very strong antioxidant activity and can be used as herbal medicines.

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Section: Bmentioning

confidence: 96%

“…(K-OOL) showed a strong antioxidant activity (IC50 < 100 ppm). Da'i et al (2016) found that the ethanol extract of P. niruri from an Indian local market showed a potential of antioxidant activity, both in in vitro and in vivo model tests. In that study, the IC 50 value in vitro test of the extract was 14.21 ± 0.73 mg/ml.…”

Section: Figurementioning

confidence: 99%

The Combination of Phyllanthus niruri, Euphorbia hirta, and Loranthus sp. as a Source of Antioxidant Agents

Kristiani

Kasmiyati

2021

J Bio Bio Edu

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“…A standard antioxidant (ascorbic acid) was used as control to compare the aqueous extract antioxidant efficacy and confirmed the strong antioxidant activity, however, ethanolic extracts of P. amarus and P. niruri showed higher ROS scavenging response compared to aqueous extracts [ 9 , 50 , 53 ]. Many studies have confirmed the presence in P. niruri extracts of quercetin, which is considered as potential natural antioxidant which is even more powerful antioxidant than vitamin E [ 49 , 54 ]. P. acidus fruit ethanol and water extracts were also studied to find antioxidant and cytotoxic levels, which showed that water extracts are more potent antioxidant and cytotoxic compared to fruit ethanolic extracts [ 55 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Nisar

Ahmed

et al. 2018

Molecules

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Medicinal plants have served humans since prehistoric times to treat various ailments. Both developed and underdeveloped countries rely on traditional systems of medication using natural sources from plants. Phyllanthus is one of the largest genus in the family Phyllanthaceae, comprising over 700 well known species cosmopolitan in distribution mainly in the tropics and subtropics. Phyllanthus species are being in constant used in traditional medications to cure an array of human diseases (constipation, inhalation related, arthritis, loss of appetite, injuries, conjunctivitis, diarrhoea, running nose, common cold, malaria, blennorrhagia, colic, diabetes mellitus, dysentery, indigestion, fever, gout, gonorrheal diseases of males and females, skin itching, jaundice, hepatic disorders, leucorrhea, vaginitis, menstrual irregularities, obesity, stomach pains, and tumors), confectionaries, food industry, and in some pesticides. Phyllanthus species are rich in diversity of phytochemicals e.g., tannins, terpenes, alkaloids, glycosidic compounds, saponins, and flavones etc. More in depth studies are a direly needed to identify more compounds with specific cellular functions to treat various ailments.

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“…Analisis kandungan fitokimia pada meniran memberikan respon positif terhadap senyawa fenolik, tanin, flavonoid, saponin, triterpenoid, seteroid, dan alkaloid yang memberikan aktivitas antioksidan pada ekstrak meniran (Kosnayani et al, 2019). Penelitian sebelumnya menunjukkan bahwa aktivitas antioksidan yang terkandung dalam meniran sangat tinggi (Atmadja & Yunianto, 2019;Da'i et al, 2016;Rusmana et al, 2017).…”

Section: Pendahuluanunclassified

Metode penyeduhan terhadap nilai kesukaan dan aktivitas antioksidan seduhan teh meniran (Phyllanthus niruri Linn.)

2022

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Meniran is an herbal plant that has many health benefits. Meniran tea contains phytochemicals like teas in general such as saponins, phenolics, flavonoids, and tannins. This study aims to determine the effect of the meniran leaf tea brewing method on the preference value and content of an antioxidant activity. This research was a laboratory experiment with a completely randomized design (CRD). Meniran tea was brewed using the Decoction Brew (DB), Cold Brew (CB), and True Brew (TB) methods with filter and non-filter treatments. The organoleptic test in this study used 30 untrained panelists. Organoleptic test data collection consisting of color, aroma, and taste attributes were assessed using a 9-scale hedonic scale questionnaire. Organoleptic data that had been collected was then tested for normality using Kolmogorov Smirnov, if normally distributed, continued with ANOVA statistical test and then Duncan's further test with 99% CI. Organoleptic test results in the form of attributes of color (p= 0,000), aroma (p= 0,003), and taste (p= 0,000) of panelists preferred tea with the TBF brewing method. Based on the antioxidant activity content of selected meniran tea (TBF) around 2,33 – 2,81 mg/mL. In conclusion, the panelists prefer tea with the TBF brewing method based on the attributes of color, aroma, and taste as well as high antioxidant activity.

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Antioxidant activity of Phyllanthus niruri L. herbs: in vitro and in vivo models and isolation of active compound

Cited by 7 publications

References 0 publications

The Combination of Phyllanthus niruri, Euphorbia hirta, and Loranthus sp. as a Source of Antioxidant Agents

The Combination of Phyllanthus niruri, Euphorbia hirta, and Loranthus sp. as a Source of Antioxidant Agents

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Metode penyeduhan terhadap nilai kesukaan dan aktivitas antioksidan seduhan teh meniran (Phyllanthus niruri Linn.)

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