Antioxidant Activity of New Carvone Derivatives

Pombal, Sofia; Roncero, Alejandro M.; Tobal, Ignacio E.; Garcı́a, N.; Silva, Lucía; Dı́ez, David; Mondolis, Eily; Mero, Aldahir; Morán-Pinzón, Juan; Guerrero, Estela; Rodilla, Jesús M.

doi:10.1177/1934578x20908081

Cited by 4 publications

(4 citation statements)

References 16 publications

(19 reference statements)

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“…Incubamos en la oscuridad durante 30 minutos y posteriormente, los datos de densidad óptica (DO) se obtuvieron a 492 nm. Cada evaluación se realizó por triplicado; utilizamos quercetina como sustancia de referencia y el porcentaje de inhibición del radical DPPH fue calculado a través de la siguiente fórmula: 2020) [8]. En cada pocillo de una microplaca de 96 pocillos, se colocaron 50 µL de los extractos disueltos en DMSO a diferentes concentraciones (0,48 µg/mL hasta 1000 µg/mL).…”

Section: Método a Identificación De áCidos Fenólicosunclassified

Explorando las diferencias entre el café Geisha verde y tostado: Identificación de ácidos fenólicos y actividad antioxidante

Abrego González,,

Vega,

Sánchez-Martínez

et al. 2023

apanac

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Debido a que el proceso de tostado del café puede generar cambios en sus constituyentes, y por ende en sus propiedades biológicas, buscamos identificar los ácidos fenólicos presentes en café Geisha verde y tostado, y a su vez, evaluar sus propiedades antioxidantes. Primero, se sometió la materia prima (granos de café Geisha) a un proceso de “extracción en frío” con etanol al 70% y posteriormente el perfil fenólico de los extractos etanólicos del café verde (EEtCG-V) y del café tostado (EEtCG-T) fue determinado en un HPLC-MS utilizando 280, 330 y 360 nm. La actividad antioxidante fue determinada en extractos acuosos de café Geisha verde (EACG-V) y tostado (EACG-T), obtenidos a través de un proceso de extracción en cafetera italiana, frente a los radicales: DPPH, anión superóxido no enzimático (•O2−) y peroxidación lipídica a distintas concentraciones (0,48-1000 mg/mL). Los resultados para el EEtCG-V, a 330 nm, indican la presencia de 17 picos cromatográficos correspondientes a derivados de ácidos hidroxicinámicos, similar a los detectados en el EEtCG-T, éste con la excepción de la aparición de los picos correspondientes a lactonas de los ácidos clorogénicos, relacionadas con el proceso de tostado. Para los resultados de la actividad antioxidante: frente al radical DPPH, tanto para el EACG-V y EACG-T fue discreta, en comparación al 80,4±1,2% obtenido por quercetina; frente al •O2− fue significativa para ambos extractos entre un 60 y 70% muy similar al patrón quercetina (75,8 ± 0,6%) y en la prueba de peroxidación lipídica, el EACG-T fue superior (73.0 ± 1.7%) al EACG-V (<50%), resultando similar al obtenido por nuestro patrón de Quercetina (73.7 ± 2.7%).Los resultados expuestos constituyen una parte de los primeros estudios realizados sobre extractos de café Geisha verde y tostado.

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Section: Método a Identificación De áCidos Fenólicosunclassified

Explorando las diferencias entre el café Geisha verde y tostado: Identificación de ácidos fenólicos y actividad antioxidante

Abrego González,,

Vega,

Sánchez-Martínez

et al. 2023

apanac

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show abstract

“…The DPPH free radical scavenging activity was estimated as described in the literature [17]. All extracts were dissolved in DMSO at different concentrations (31.3 -2000 µg/mL).…”

Section: Evaluation Of Antioxidant Activity 231 Determination Of Dpph Inhibition Percentagementioning

confidence: 99%

“…Nitric oxide (NO) scavenging activity was estimated by assay based on Griess Illosvoy reaction [17]. About 50 μL of the test sample (31.3 -250 µg/mL in DMSO) was mixed with 50 μL of sodium nitroprusside (10 mM), and 50 μL of Griess reagent prepared in saline phosphate buffer (pH 7.4).…”

Section: Nitric Oxide Radical Scavenging Activitymentioning

confidence: 99%

Evaluation of the Leaf Extracts of Kalanchoe pinnata and Kalanchoe daigremontiana Chemistry, Antioxidant and Anti-inflammatory Activity

Quintero

León

Morán-Pinzón

et al. 2021

EJMP

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The aim of this study was to analyze the chemical components and evaluate the biological activity of the extracts from the leaves Kalanchoe pinnata and Kalanchoe daigremontiana, which are cultivated in the province of Chiriqui, Republic of Panama. Phytochemicals components, antioxidant and anti-inflammatory activities were studied. The composition of the obtained petroleum ether, ethanol and aqueous extracts was analyzed by phytochemical screening. The antioxidant activity of the extracts was studied using three in vitro model systems (DPPH radical scavenging assay, nitric oxide radical scavenging assay, and superoxide radical scavenging activity). The anti-inflammatory activity of these species was studied using an in vivo model (ʎ-carrageenan-induced paw edema in rats). Phytochemical analysis of the extracts showed the presence of alkaloids, steroids, triterpenes, flavonoids, phenolic compounds, saponins and glycosides. The greatest radical inhibitory effect was observed in the DPPH model where the ethanolic extracts of both species developed a concentration-dependent inhibitory effect, the K. pinnata extract reached a maximum inhibitory effect of 49.5 ± 5.6% (2000

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“…Carvone, a forest biomass resource containing the chemical structure of monocyclic monoterpenoid, is naturally found in a variety of plant essential oils [2], such as Carum carvi L. [3,4], Anethum graveolens L. [4], and Mentha spicata L., [5,6] and has been reported to show a wide range of pharmacological activities, including antioxidative [6,7], antimanic [8], anti-inflammatory [9,10], antifungal [11,12], repellent [13], and anticancer [4,14,15] activities. Moreover, the molecular skeleton of carvone has been developed into an important building block for discovering leading compounds with antiproliferative activity [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antiproliferative activity, 3D‐QSAR, and molecular docking studies of novel L‐carvone‐derived pyrimidine‐urea compounds

Meng,

Zhang,

Duan

et al. 2024

Journal of Heterocyclic Chem

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To explore novel natural product‐based nitrogen‐containing heterocyclic compounds with antiproliferative activity, 20 L‐carvone‐derived pyrimidine‐urea compounds 4a–4t were synthesized through the multi‐step reaction of L‐carvone, and structurally characterized by Fourier transform infrared (FT‐IR), hydrogen‐1 nuclear magnetic resonance (1H‐NMR), Carbon‐13 nuclear magnetic resonance (13C‐NMR), and High‐resolution mass spectrometry (HRMS). Besides, the in vitro antiproliferative activity of the target compounds against HepG2, Hela, and MCF‐7 cells was evaluated by methyl thiazolyl tetrazolium (MTT) assay. According to the results, the target compounds showed certain inhibitory activities against the tested cancer cell lines, and five compounds (4b, 4h, 4k, 4l, and 4t) exhibited better inhibition activities against Hela cells than the positive control (5‐FU). Among them, compound 4b held significant antiproliferative activities against Hela and HepG2 cells, and thus deserved further study as a leading compound of new anticancer drugs. In addition, an effective and reasonable three‐dimensional quantitative structure‐activity relationships (3D‐QSAR) model was built by the Comparative molecular field analysis (CoMFA) method to analyze the relationship between the structures of the target compounds and their antiproliferative activities (expressed as pIC50) against Hela cells, and proven to have good predictive ability. Molecular docking was carried out to study the possible binding modes of compound 4b and Survivin, and it was found that compound 4b could be well embedded into the active site, along with the formation of several hydrogen bonds and hydrophobic interactions.

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Antioxidant Activity of New Carvone Derivatives

Cited by 4 publications

References 16 publications

Explorando las diferencias entre el café Geisha verde y tostado: Identificación de ácidos fenólicos y actividad antioxidante

Explorando las diferencias entre el café Geisha verde y tostado: Identificación de ácidos fenólicos y actividad antioxidante

Evaluation of the Leaf Extracts of Kalanchoe pinnata and Kalanchoe daigremontiana Chemistry, Antioxidant and Anti-inflammatory Activity

Synthesis, antiproliferative activity, 3D‐QSAR, and molecular docking studies of novel L‐carvone‐derived pyrimidine‐urea compounds

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