Antioxidant activity of nanomaterials

Valgimigli, Luca; Baschieri, Andrea; Amorati, Riccardo

doi:10.1039/c8tb00107c

Cited by 172 publications

(110 citation statements)

References 107 publications

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“…14 In recent years, catalytic NPs bearing anti-oxidant like properties (termed as nano-antioxidants) have garnered significant attention. 15 These nano-antioxidants have numerous advantages over natural anti-oxidants, such as the ease of mass production, high thermal and biological stability, multi-functionality, and tunable nature. A variety of inorganic nanoparticles with ROS scavenging properties have been discovered.…”

Section: Introductionmentioning

confidence: 99%

<p>Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain</p>

Kuthati

Busa

Davuluri

et al. 2019

IJN

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Background: Reactive oxygen species (ROS) induced oxidative stress is linked to numerous neurological diseases, including neuropathic pain. Natural ROS scavenging enzymes like superoxide dismutase (SOD) and catalase have been found to be efficient in alleviating neuropathic pain. However, their sensitivity towards extreme pH and a short half-life limit their efficacy in vivo. Manganese oxide nanoparticles (MONPs) are recently known to possess ROS scavenging properties. In this study, MONPs were examined for their therapeutic effect on neuropathic pain. Methods: The MONPs were synthesized by a hydrothermal method. The synthesized MONPs were characterized by UV/Vis, TEM, SEM, FTIR, NTA and XRD. The biocompatibility of the nanoparticles is evaluated in neural cells using LDH assay. MONPs were evaluated for their antioxidant activity by DPPH assay. In addition, in vitro ROS scavenging properties were examined in bone marrow-derived macrophage (BMDM) cells using 2ʹ,7ʹdichlorofluorescin diacetate (DCFDA) assay. To evaluate the in vivo efficacy of nanoparticles, neuropathic pain was induced in Wistar rats by partial sciatic nerve transection (PSNT). On post-transection days 14 to 18, rats were intrathecally injected with MONPs and paw withdrawal threshold was measured. The spinal cords were collected and processed for Western blotting and histological analysis. Results: The synthesized MONPs were biocompatible and showed effective antioxidant activity against DPPH free radical scavenging. Further, the nanoparticles scavenged ROS efficiently in vitro in BMDM and their intrathecal administration significantly reduced mechanical allodynia as well as the expression of cyclooxygenase-2 (COX-2), an important mediator of chronic and inflammatory pain in the spinal dorsal horns of PSNT rats. Conclusion: As ROS play a significant role in neuropathic pain, we expect that MONPs could be a promising tool for the treatment of various inflammatory diseases and might also serve as a potential nanocarrier for the delivery of analgesics.

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Section: Introductionmentioning

confidence: 99%

<p>Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain</p>

Kuthati

Busa

Davuluri

et al. 2019

IJN

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“…Such novel synergistic nanoantioxidants were recently described for halloysite externally decorated with tocopherol-like moieties and containing quercetin inside the nanotube [30]. More examples of antioxidants supported by nanoparticles have been described in a recent review [31]. Our previous projects were focused on the antioxidant activity of phenolic antioxidants covalently bonded to fullerene [32][33][34], as we noticed that pristine C 60 inhibits high-temperature autoxidation of saturated hydrocarbons [35].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Metal Nanoparticles Coated with Tocopherol-Like Residues—The Importance of Studies in Homo- and Heterogeneous Systems

2019

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Functionalized nanoparticles (NPs) attract great attention in pharmacy, diagnostics, and biomedical areas due to benefits like localization and unique interactions of NPs with biocomponents of living cells. In the present paper, we prepared and characterized two kinds of gold nanoparticles (AuNPs) coated with α-tocopherol-like residues: 1A were soluble in non-polar solvents and their antioxidant activity was tested during the peroxidation of a model hydrocarbon in a homogeneous system, whereas nanoparticles 1B were soluble in polar solvents and were applied as antioxidants in micellar and liposomal systems. The effectiveness of 1A is comparable to 2,2,5,7,8-pentamethylchroman-6-ol (PMHC, an analogue of α-tocopherol). Taking the results of the kinetic measurements, we calculated an average number of 2150 chromanol residues per one NP, suggesting a thick organic coating around the metal core. In heterogeneous systems, the peroxidation of methyl linoleate dispersed in Triton X-100 micelles or DMPC liposomes resulted in the observation that 1B (545 chromanol residues per one NP) was active enough to effectively inhibit peroxidation in a micellar system, but in a liposomal system, 1B behaved as a retardant (no clear induction period). The importance of microenvironment in heterogeneous systems on the overall antioxidant activity of nanoparticles is discussed.

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“…Thus, the release of more or less MH in the absorption site would not be a preponderant factor, since the process still depends on the physicochemical properties of the molecule in the biological milieu. However, it is important to consider that although the release mechanism of some large and small molecules from silica matrices has been widely reported [62], to our knowledge, there are no reports on the release mechanism of polyphenols from systems called nanoantioxidants [13,63] based on silica. Unveiling this mechanism could anticipate biological behavior and optimize the design of pharmaceutical formulations to improve oral bioavailability.…”

Section: Resultsmentioning

confidence: 99%

Nanoantioxidant–Based Silica Particles as Flavonoid Carrier for Drug Delivery Applications

2020

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Nanosystems used in pharmaceutical formulations have shown promising results in enhancing the administration of drugs of difficult formulations. In particular, porous silica nanoparticles have demonstrated excellent properties for application in biological systems; however, there are still several challenges related to the development of more effective and biocompatible materials. An interesting approach to enhance these nanomaterials has been the development of nanoantioxidant carriers. In this work, a hybrid nanoantioxidant carrier based on porous silica nanoplatform with rosmarinic acid antioxidant immobilized on its surface were developed and characterized. Techniques such as dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), N2 adsorption–desorption measurements, differential scanning calorimetry (DSC), Fourier transform–infrared spectroscopy (FT-IR), and 2,2-diphenyl-1-picrylhydrazyl (DPPH●) assay were used to characterize and evaluate the antioxidant activity of nanocarriers. In addition, drug release profile was evaluated using two biorelevant media. The antioxidant activity of rosmarinic acid was maintained, suggesting the correct disposition of the moiety. Kinetic studies reveal that more morin is released in the simulated intestinal fluid than in the gastric one, while an anomalous non–Fickian release mechanism was observed. These results suggest a promising antioxidant nanocarrier suitable for future application in drug delivery.

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Antioxidant activity of nanomaterials

Abstract: In this review, the main families of nanoantioxidants and the chemical methods used to measure their antioxidant activity are reported.

Cited by 172 publications

References 107 publications

<p>Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain</p>

<p>Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain</p>

Antioxidant Activity of Metal Nanoparticles Coated with Tocopherol-Like Residues—The Importance of Studies in Homo- and Heterogeneous Systems

Nanoantioxidant–Based Silica Particles as Flavonoid Carrier for Drug Delivery Applications

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