Antioxidant Activity of Leaves of Salvia Species in Enzyme-Dependent and Enzyme-Independent Systems of Lipid Peroxidation and their Phenolic Constituents

Zupkó, István; Hohmann, Judit; Rédei, Dóra; Fekete, György; Janicsák, Gábor; Máthé, Imre

doi:10.1055/s-2001-14327

Cited by 103 publications

(58 citation statements)

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“…Therefore, precise regulation of superoxide and NO production appears to be critical for the survival of islet grafts in our model. Furthermore, because Ros A inhibits the complement inflammatory process and has anti-thrombotic and anti-platelet effects (Zou et al, 1993;Sahu et al, 1999;Zupko et al, 2001), we suspect that Ros A may also have therapeutic potential for protecting against the immediate blood-mediated inflammatory reaction (IBMIR) often observed in clinical islet transplantation.…”

Section: Discussionmentioning

confidence: 99%

Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody

et al. 2008

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Pancreatic islet transplantation can correct the abnormal glucose metabolism of Type 1 diabetes. Although immunosuppressants greatly reduce the acute rejection rate in transplant patients, the long-term side effects can be debilitating. Therefore, researchers are seeking to develop new immunosuppressive regimens that induce maximal levels of immunosuppression with minor side effects. Rosmarinic acid (Ros A) is a secondary metabolite of certain herbs and has multiple biological activities, including anti-inflammatory effects. Here, we have investigated whether treatment of mice with a combination of Ros A and anti-CD154 monoclonal antibody (MR1) improves islet allograft survival in a murine model. After transplantation, the mice were treated with either Ros A, MR1, or both (the "double" treatment). Allograft survival was prolonged in the double-treated animals compared to animals that received only Ros A or MR1. As is the case with the single-treated animals at 15 days after transplantation, the double-treated recipients did not display a significant decrease in the expression of cytokines or the population of activated T cells. Infiltrating CD3 + T cells were reduced in the MR1-or double therapy relative to control or RosA group. However, at the same time point, double-treated graft showed fewer apoptotic cells and increased expression of insulin and glucagons, compared to the single-treatment groups. Furthermore, long-term (＞ 150 days) allografts that were received with double therapy exhibited larger islet clusters and contained more insulin-and glucagon-positive cells, relative to the MR1-treated grafts. In conclusion, treatment with both Ros A and MR1 has a synergistic effect in murine islet allotransplantation.

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Section: Discussionmentioning

confidence: 99%

Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody

et al. 2008

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“…Numerous studies were carried out on some of these plants, e.g. rosemary, sage, oregano, which resulted in a development of natural antioxidant formulations for food, cosmetic and other applications (3,13,23,28). However, scientific information on antioxidant properties of various plants, particularly those that are less widely used in culinary and medicine is still rather scarce.…”

Section: Introductionmentioning

confidence: 99%

Radical Scavenging Capacity of Seeds and Leaves Ethanol Extracts ofCynara Scolymus L.—A Comparative Study

Georgieva

Karamalakova

Nikolova

et al. 2012

Biotechnology & Biotechnological Equipment

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“…Previous studies demonstrated that many Salvia species and their isolated constituents possess antioxidant activity (Zupko et al 2001), antiinflammatory activity (Howes et al 2003) and cholinesterase inhibition effect (Perry et al 2001.…”

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confidence: 99%

Effect of Sage Extract on Alkaline Phosphatase, Enterocyte Proliferative Activity and Growth Performance in Chickens

et al. 2010

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The effects of sage extract on the activity of intestinal alkaline phosphatase (AP), proliferative ability of enterocytes, and growth performance in chickens were studied during 42 days of the experiment under commercial conditions. A significant increase of body weight gain was found in chickens fed with sage extract in the grower period (17-29 days of age) and in the finisher period (30-42 day of age). Total serum proteins were significantly (p < 0.05) increased at 29 days of age in animals treated with sage extract. A significant (p < 0.001) decrease in activity of intestinal AP was demonstrated on 29 and 42 days in animals fed with sage extract complemented diet. Proliferative activity of enterocytes was increased (p < 0.01) in the finisher period along the duodenal villi in animals treated with sage extract. We conclude that the higher growth performance was probably due to improved endogenous secretion of the liver as a consequence of increased total proteins mainly in the grower period. Decreased activity of intestinal alkaline phosphatase was not in correlation with proliferative ability of enterocytes and the lower activity of AP could be influenced by improved digestion of lipids.

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Antioxidant Activity of Leaves of Salvia Species in Enzyme-Dependent and Enzyme-Independent Systems of Lipid Peroxidation and their Phenolic Constituents

Cited by 103 publications

References 0 publications

Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody

Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody

Radical Scavenging Capacity of Seeds and Leaves Ethanol Extracts ofCynara Scolymus L.—A Comparative Study

Effect of Sage Extract on Alkaline Phosphatase, Enterocyte Proliferative Activity and Growth Performance in Chickens

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