Antioxidant activity of α and β-amyrin isolated from Myrcianthes pungens leaves

Cardoso, Bruna Karen; Oliveira, Hérika Line Marko de; Melo, Ulisses Z.; Fernandez, Carla Maria Mariano; Campos, Caio Franco de Araújo Almeida; Gonçalves, José Eduardo; Laverde, Antônio; Romagnolo, Mariza Barion; Linde, Giani Andréa; Gazim, Zilda Cristiani

doi:10.1080/14786419.2018.1525715

Cited by 30 publications

(16 citation statements)

References 11 publications

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“…Others researchers found that lupeol acetate ameliorates collagen-induced arthritis through suppression of inflammatory cytokines and inhibition of bone erosion [24]. Indeed, the potential antioxidant and free radical scavenging effects of amyrin and lupeol have been demonstrated both in vitro and in vivo [25][26][27][28]. A recent report showed increased antioxidant activity and suppressed proinflammatory cytokine expressions in obese OA rats fed with SNO, further consolidating our previous findings [29].…”

Section: Introductionsupporting

confidence: 66%

Shea Nut Oil Extracts Enhance the Intra-Articular Sodium Hyaluronate Effectiveness on Surgically Induced OA Progression in Rats

Chen

Wong

2020

Nutrients

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Osteoarthritis (OA) progression is associated with joint pain and stiffness. Intra-articular hyaluronic acid (IAHA) injection in knee OA restores the viscoelasticity of the joint and prevents cartilage damage. Shea nut oil extract (SNO) was shown to provide chondroprotection on surgically-induced OA progression in rats. Here we aim to examine IAHA injection supplemented with SNO diet for a synergetic evaluation on the disease progression in OA rats. We employed an anterior cruciate ligament transection plus medial meniscectomy-induced knee OA rat model with up to 12 weeks of sign/behavior observation (knee width, weight-bearing) and histological assessments of joint damage. We found both IAHA and SNO alone significantly attenuated histological changes of cartilage degeneration and synovial reactions in these knee OA rats. Nonetheless, oral SNO alone mitigated OA pain and inflammation while IAHA alone had no significant impact on the weight-bearing test and knee joint swelling. Moreover, with IAHA-treated rats fed with oral SNO diet, additional anti-inflammatory and anti-nociceptive effects were found, which further enhanced and maintained IAHA protection. Given the differential phenotype of oral SNO vs. IAHA, a regimen of IAHA coupled with SNO supplement provides a long-term effect of IAHA treatment. Taken together, the SNO supplement can be safely used as an adjuvant diet for chronic symptomatic relief of OA coupled with IAHA management.

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Section: Introductionsupporting

confidence: 66%

Shea Nut Oil Extracts Enhance the Intra-Articular Sodium Hyaluronate Effectiveness on Surgically Induced OA Progression in Rats

Chen

Wong

2020

Nutrients

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“…Such compounds are known for their antimicrobial and antioxidant activities (Ali et al, 2017;Pinto et al, 2017). β-Amyrin (8.09%) has been found in various plant species including Monotheca buxifolia, Myrcianthes pungens and Melia azedarach, showing antifungal, anti-inflammatory and antioxidant activities (Jabeen et al, 2011;Okoye et al, 2014;Cardoso et al, 2020;Javed et al, 2021). α-Amyrin acetate (8.25%) showed antihyperglycaemic activity in rats (Singh et al, 2009).…”

Section: Resultsmentioning

confidence: 99%

BIOCHEMICAL PROFILE OF Calotropis procera FLOWERS

Ferdosi¹,

Khan²,

Javaid³

et al. 2021

PJWSR

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Calotropis procera is a medicinal weed of family Asclepiadaceae. This study was carried out to explore the biochemical profile of C. procera flowers collected from Southern Punjab region of Pakistan. Methanolic flower extract of C. procera was subjected to GC-MS analysis. There were 30 compounds identified in this extract. The predominant compound was γ-sitosterol with 15.39% peak area. Other abundantly occurring compounds included stigmasterol (9.22%), 9,12-octadecadienoic acid (Z,Z)-, methyl ester (9.01%), campesterol (8.63%), α-amyrin acetate (8.25%), β-amyrin (8.09%), hexadecanoic acid, methyl ester (7.91%), 11-octadecenoic acid, methyl ester (6.15%), and 2-methoxy-4-vinylphenol (5.66%). Moderately abundant compounds included nonacos-1-ene (2.83%), methyl stearate (1.57%), pentacosane (1.44%), phytol (1.33%), heptacos-1-ene (1.20%), heneicosane (1.19%), and 1-hexacosene (1.09%). The remaining less abundant compounds were present with peak areas less than 1%. Literature survey showed that the major compounds identified in the flower extract of C. procera possess various bioactivities including antidiabetic, anticancer, antihyperglycemic, antioxidant, antimicrobial and anti-inflamatory.

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“…The antioxidant activity of triterpenoid was observed in propolis from Cameroon [ 44 ], a medicinal fungus, Sanghuangporus sanghuang [ 45 ], and the stem bark of Reissantia indica [ 46 ]. It is possible that cycloartenol, α -amyrin, and β -amyrin that are classified as triterpenoids in the extract may have a synergistic effect on the antioxidant activity of HEP [ 47 – 49 ]. In contrast, the low antioxidant activity of EEP may be partly derived from phenolic compounds.…”

Section: Discussionmentioning

confidence: 99%

The Oral Wound Healing Potential of Thai Propolis Based on Its Antioxidant Activity and Stimulation of Oral Fibroblast Migration and Proliferation

Jongjitaree

Koontongkaew

Niyomtham

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Introduction. Propolis has demonstrated wound healing effects. Propolis’ effects vary based on its composition and geographical origin. However, there are few reports on the effects of propolis on oral wound healing. The aim of this study was to evaluate the antioxidant and in vitro gingival wound healing effects of the n-hexane extract of propolis (HEP), ethyl acetate extract of propolis (EEP), and aqueous extract of propolis (AEP) fractions of the ethanol extract of Thai propolis. Materials and Methods. The crude ethanol extract of propolis was obtained by maceration with 95% ethanol that was sequentially fractionated with hexane, ethyl acetate, and distilled water. The chemical profiles of the samples were assessed by thin-layer chromatography (TLC) and gas chromatography-mass spectrometry (GC-MS). Antioxidant activity was determined using DPPH and FRAP assays. The effects of the propolis fractions on human gingival fibroblast (HGF) proliferation, migration, and in vitro wound healing were determined by MTT, modified Boyden chamber, and scratch assay, respectively. Results. We found that solvent polarity greatly affected the extract yield and TLC profiles. The highest extract yield was found in HEP (38.88%), followed by EEP (19.8%) and AEP (1.42%). TLC revealed 7 spots in the crude ethanol extract (Rf 0.36–0.80), 6 spots in HEP (Rf 0.42–0.80) and EEP (Rf 0.36–0.72), and 4 spots in AEP (Rf 0.17–0.79). GC-MS analysis revealed a high amount of triterpenoids in HEP (82.97%) compared with EEP (28.96%). However, no triterpenoid was found in AEP. The highest antioxidant activity and stimulation of HGF proliferation were observed in HEP, followed by EEP and AEP. HEP and EEP, but not AEP, enhanced HGF migration. However, all propolis fractions induced wound closure. Conclusions. HEP contained a large amount of triterpenoids. Antioxidant and in vitro wound closure effects were found in HEP, EEP, and AEP fractions.

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Antioxidant activity of α and β-amyrin isolated from Myrcianthes pungens leaves

Cited by 30 publications

References 11 publications

Shea Nut Oil Extracts Enhance the Intra-Articular Sodium Hyaluronate Effectiveness on Surgically Induced OA Progression in Rats

Shea Nut Oil Extracts Enhance the Intra-Articular Sodium Hyaluronate Effectiveness on Surgically Induced OA Progression in Rats

BIOCHEMICAL PROFILE OF Calotropis procera FLOWERS

The Oral Wound Healing Potential of Thai Propolis Based on Its Antioxidant Activity and Stimulation of Oral Fibroblast Migration and Proliferation

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