Antioxidant Activity of Graft Chitosan Derivatives

Abstract

Graft chitosan derivatives (CMCTS‐g‐MAAS and CMCTS‐g‐AAS) were prepared by the graft copolymerization of methacrylic acid sodium (MAAS) and acrylic acid sodium (AAS) onto the etherification product of chitosan‐carboxymethyl chitosan (CMCTS). Their antioxidant activity was estimated as superoxide anion scavengers by chemiluminescence techniques. The derivatives with low grafting percentages have a relatively low 50% inhibition concentration (IC50), which could be related to the fact that they have different contents of hydroxyl and amino groups in the polymer chains.Superoxide radical scavenging activity of CMCTS‐g‐MAAS.magnified imageSuperoxide radical scavenging activity of CMCTS‐g‐MAAS.

Bioactive cotton fabrics containing chitosan and biologically active substances extracted from plants

“…In our experiments, the scavenging activity of the samples of crosslinked chitosan deposed on cotton, measured at the same concentration as the samples having VT, was almost zero (results are in concordance with the above mentioned literature data [40][41][42][43]; hence all antioxidant activity determined was produced by the VT included into the chitosan-coated supports.…”

“…Only at very high concentrations can chitosan scavenge superoxide anions. This may be related to the formation of strong intermolecular and intra-molecular hydrogen bonds that inhibited the reactivity of hydroxyl and amino groups in the polymer chains [41]. Some authors reported an important antioxidant activity for Low Molecular Weight (LWM) chitosan [42] and LMW and soluble Medium Molecular Weight chitosan with a 98.50% N-deacetylation [43].…”

Chitin and Chitosan Preparation from Marine Sources. Structure, Properties and Applications

“…It was reported that chitosan and its derivatives act as antioxidants by scavenging oxygen radicals such as hydroxyl, superoxide, alkyl as well as highly stable DPPH radicals tested in vitro [ 204 ]. Sun and collaborators [ 205 ] reported that chitosan and their derivatives act as hydrogen donors to prevent the oxidative sequence.…”

Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

“…The data suggested that N -CESC can be utilized to produce chitosan derivatives with good biochemical characteristics in vitro [ 75 ]. Graft chitosan derivatives with low grafting percentages, produced by graft copolymerization of methacrylic acid sodium and acrylic acid sodium onto the etherification product of chitosan-carboxymethyl chitosan, exhibit a relatively low 50% inhibition concentration (IC 50 ) for their radical scavenging activity, which could be attributed to their different contents of hydroxyl and amino groups in the polymer chains [ 76 ].…”