Antioxidant Activity of Flavonoid Rich Fraction of <i>Ligaria cuneifolia</i> (Loranthaceae)

Dobrecky, Cecilia; Marchini, Timoteo; Ricco, Rafael A.; Garcés, Mariana; Gadano, Andrea; Carballo, Marta A.; Wagner, Marcelo L.; Lucangioli, Silvia; Evelson, Pablo

doi:10.1002/cbdv.202000302

Cited by 11 publications

(14 citation statements)

References 49 publications

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“…Flavonoids are considered as natural antioxidants since they are part of the defense mechanism initiated by plants to counteract the toxic effects of free radicals. [14] In our study, the samples from July presented the highest amount of total flavonoid content (3.89 mg/g dw), which was significantly higher than the content of the samples from other months (2.15 ~2.54 mg/g dw) (Table 1). There was no significant difference in content of samples from August, September, October and November.…”

Section: Total Flavonoid Contentmentioning

confidence: 46%

Phenolics, Flavonoids Content and Antioxidant Activities of Tuber indicum at Different Maturity Stages

Yang

Liang

Zhou

et al. 2022

Chemistry & Biodiversity

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The Chinese black truffle Tuber indicum (Ascomycota, Pezizales) is an ectomycorrhizal fungus forming hypogeous edible ascocarps. As a famous wild edible mushroom in the world, this species also attracted an increasing interest in their chemical composition and pharmacological activity. In this study, the total phenolic content, total flavonoid content and antioxidant activities of Tuber indicum collected from July to November at different maturity stages in China were analyzed. Our results showed that T. indicum collected in July (immature stage) possessed the highest amount of flavonoids (3.89 mg/g dw) and the highest ABTS * + scavenging activity (EC 50 = 3.73 mg/ml). In addition, those samples collected in August (moderate mature stage) contained the highest phenolics content (4.78 mg/g dw), the highest DPPH * radical scavenging activity (EC 50 = 3.73 mg/ml) and ferric reducing activity power (243.63 μmol FeSO 4 /g). The study reveals T. indicum in the early maturity stage yield significantly higher content of phenolics and flavonoids and possessed stronger antioxidant activity than those collected in other months. This study provided important data for understanding the relationship between maturity stages and truffle formation and evaluating the quality of Chinese black truffle at different maturity.

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Section: Total Flavonoid Contentmentioning

confidence: 46%

Phenolics, Flavonoids Content and Antioxidant Activities of Tuber indicum at Different Maturity Stages

Yang

Liang

Zhou

et al. 2022

Chemistry & Biodiversity

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“…Bio‐guided fractionation is an important biotechnological strategy to identify new sources of antioxidant‐like compounds. For example, Dobrecky et al [36] . showed that fractionation of Ligaria cuneifolia extracts enhanced the content of total phenolics, flavonoids, hydroxycinnamic acids, along with total and condensed tannins.…”

Section: Discussionmentioning

confidence: 99%

HPLC/HR‐MS‐Based Metabolite Profiling and Chemometrics: A Powerful Approach to Identify Bioactive Compounds from Abarema cochliacarpos

Farias

Cerqueira

Colepicolo

et al. 2021

Chemistry & Biodiversity

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Despite its importance as a medicinal plant, there is a lack of studies that assessed the chemical composition of A. cochliacarpos extracts. Herein, we used a metabolite profiling approach and chemometrics as a powerful strategy to correlate the chemical composition with the antioxidant activity of A. cochliacarpos extracts. Extracts obtained with ethyl acetate showed greater antioxidant activity and higher total phenolic content than extracts obtained with hexane. The chemical composition was assessed by HPLC/HR‐MS and it encompassed fatty alcohols, terpenoids, phenolic derivatives, lipids, carotenoid‐like compounds, alkaloids, flavonoids, polyketides, and glycerophospholipids. Chemometrics successfully differentiated not only the chemical composition of extracts in response to the nature of the extraction solvent and the botanical part used during extraction but also it allowed us to associate the chemical composition with the antioxidant activity of the extracts, which might be particularly helpful for drug discovery and development programs.

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“…After 10 min, the absorbance of the mixture was measured at 517 nm. A calibration curve was prepared using Trolox (vitamin E analogue) as standard, and results were expressed as nmol Trolox Eq/mg sample and DPPH inhibition percentage [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy

et al. 2022

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Among respiratory infections, tuberculosis was the second deadliest infectious disease in 2020 behind COVID-19. Inhalable nanocarriers offer the possibility of actively targeting anti-tuberculosis drugs to the lungs, especially to alveolar macrophages (cellular reservoirs of the Mycobacterium tuberculosis). Our strategy was based on the development of a mannose-decorated micellar nanoformulation based in Soluplus® to co-encapsulate rifampicin and curcumin. The former is one of the most effective anti-tuberculosis first-line drugs, while curcumin has demonstrated potential anti-mycobacterial properties. Mannose-coated rifampicin (10 mg/mL)–curcumin (5 mg/mL)-loaded polymeric micelles (10% w/v) demonstrated excellent colloidal properties with micellar size ~108 ± 1 nm after freeze-drying, and they remain stable under dilution in simulated interstitial lung fluid. Drug-loaded polymeric micelles were suitable for drug delivery to the deep lung with lung accumulation, according to the in vitro nebulization studies and the in vivo biodistribution assays of radiolabeled (99mTc) polymeric micelles, respectively. Hence, the nanoformulation did not exhibit hemolytic potential. Interestingly, the addition of mannose significantly improved (5.2-fold) the microbicidal efficacy against Mycobacterium tuberculosis H37Rv of the drug-co-loaded systems in comparison with their counterpart mannose-free polymeric micelles. Thus, this novel inhaled nanoformulation has demonstrated its potential for active drug delivery in pulmonary tuberculosis therapy.

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Antioxidant Activity of Flavonoid Rich Fraction of Ligaria cuneifolia (Loranthaceae)

Cited by 11 publications

References 49 publications

Phenolics, Flavonoids Content and Antioxidant Activities of Tuber indicum at Different Maturity Stages

Phenolics, Flavonoids Content and Antioxidant Activities of Tuber indicum at Different Maturity Stages

HPLC/HR‐MS‐Based Metabolite Profiling and Chemometrics: A Powerful Approach to Identify Bioactive Compounds from Abarema cochliacarpos

Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy

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